PLACENTAL EPITHELIAL-MESENCHYMAL TRANSITION IN PREECLAMPSIA


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Abstract

Objective. To analyze the expression of markers for the Wnt signaling pathway in the placental epithelialmesenchymal transition in early and late preeclampsia. Subjects and methods. The study included 52 women who were divided into three groups: early preeclampsia (n = 17), late preeclampsia (n = 14) and a control group (n = 21). The investigators determined the relative expression of the genes implicated in the epithelial-mesenchymal transition by polymerase chain reaction, as well as that of proteins by Western blot analysis in the placental samples. Results. The level of the relative protein expression of vimentin, E- and N-cadherins did not differ in health and in preeclampsia. The expression of the SNAI1, β-catenin, and GSK3beta genes was also observed at the same level as that in the control samples from the control group. Conclusion. There were no differences in the work of the Wnt signaling cascade involved in the epithelialmesenchymal transition during early and late PE and uncomplicated pregnancy.

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About the authors

P. A Vishnyakova

Email: vpa2002@mail.ru
researcher at the Laboratory of mitochondrial medicine, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia. 117997, Russia, Moscow, Ac. Oparina str. 4

N. V Tarasova

Email: n_tarasova@oparina4.ru
PhD, researcher at the Laboratory of mitochondrial medicine, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia 117997, Russia, Moscow, Ac. Oparina str. 4

M. A Volodina

Email: m_volodina@oparina4.ru
PhD, researcher at the Laboratory of mitochondrial medicine, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia 117997, Russia, Moscow, Ac. Oparina str. 4

M. V Marey

Email: m_marey@oparina4.ru
researcher at the Laboratory of mitochondrial medicine, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia. 117997, Russia, Moscow, Ac. Oparina str. 4

Z. S Khodzhaeva

Email: zkhodjaeva@mail.ru
MD, Professor, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia. 117997, Russia, Moscow, Ac. Oparina str. 4

N. E Kan

Email: kan-med@mail.ru
MD, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia. 117997, Russia, Moscow, Ac. Oparina str. 4

M. Yu Vysokikh

Email: m_vysokikh@oparina4.ru
PhD, Head of mitochondrial medicine research group, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia. 117997, Russia, Moscow, Ac. Oparina str. 4

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