IMPAIRED STRUCTURAL AND FUNCTIONAL PROPERTIES OF HEMOGLOBIN IN THE PATHOGENESIS OF FETAL AND NEONATAL HYPOXIA


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Abstract

Objective. To investigate major risk factors of fetal and neonatal hypoxia and the role of the impaired structural and functional state of hemoglobin in its pathogenesis. Subjects and methods. A total of 226 newborn infants with cerebral ischemia were examined. A control group consisted of 50 apparently healthy neonates. Results. Progressive pathophysiological disorders in the conformation of hemoglobin and its ability to bind and release oxygen were ascertained to develop in the red blood cells of the newborn infants who had experienced perinatal hypoxia. Such impairments correlated with the severity of cerebral ischemia. Gassing with oxygen decreased the ability of hemoglobin to bind ligands and deteriorated its affinity for the latter. Conclusion. The findings permit the use of Raman spectroscopic data to assess the severity of prior hypoxia and the correction of oxygenation parameters in newborns with cerebral ischemia.

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About the authors

A. P MARUSOV

N.P. Ogarev Mordovia State Medical University

Email: inst-med@adm.mrsu.ru
MD, Professor, Department of obstetrics and gynecology Saransk 430032, Ulyanova str. 26A, Russia

L. V LEDYAIKINA

N.P. Ogarev Mordovia State Medical University; Mordovian Clinical Perinatal Center

Email: ledlv@list.ru
MD, Professor of Pediatrics, Deputy chief physician of Pediatrics, chief freelance neonatologist of the Republic of Mordovia Saransk 430032, Ulyanova str. 26A, Russia; Saransk 430013, Pobedy str. 18, Russia

L. A BALYKOVA

N.P. Ogarev Mordovia State Medical University

Email: inst-med@adm.mrsu.ru
MD, Professor, Director Saransk 430032, Ulyanova str. 26A, Russia

A. V GERASIMENKO

Mordovian Clinical Perinatal Center

Email: perinatrm@mail.ru
MD, Professor, honored doctor of the Republic of Mordovia, Director Saransk 430013, Pobedy str. 18, Russia

E. B AKIMOVA

N.P. Ogarev Mordovia State Medical University

Email: blackmoon220@mail.ru
doctor-Intern, Department of Pediatrics Saransk 430032, Ulyanova str. 26A, Russia

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