The modern concepts of etiology and pathogenesis placenta accreta and prospects of its prediction by molecular diagnostics


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Abstract

Objective. To conduct a systematic analysis of the data available in the current literature, risk factors, pathogenesis and markers, determined by laboratory diagnostic methods that indicate a placenta accreta. Subject and methods. The survey includes data of foreign and domestic items found in Pubmed on the subject, published in the last 5 years. Results. There are the basic molecular mechanisms that lead to placenta accreta. It is described risk factors and laboratory markers that allow to diagnose placenta accreta. Conclusion. There are many theories that consider the pathogenesis of placenta accrete by many sides. The most common one postulates about the important role of hypoxic factor with reduced vascular component of scar tissue on the uterus. It explains the high prevalence of this disease among women who have a caesarean section that was performed previously. A perspective direction is the prediction and diagnosis of placenta accreta by detecting of laboratory markers: some proteins, fetal DNA, mRNA, thereby complementing the instrumental imaging.

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About the authors

A. A Vinitskiy

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: drvinitskiy@gmail.com
Postgraduate student of maternity departments

R. G Shmakov

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: r_shmakov@oparina4.ru
MD, PhD, the chief medical officer

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