Genetic factors in the development of recurrent miscarriage: An overview of the data of meta-analyses
- Authors: Trifonova E.A.1, Ganzha O.A.1, Gabidulina T.V.2, Devyatyarova L.L.3, Sotnikova L.S.2, Stepanov V.A.1
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Affiliations:
- Research Institute of Medical Genetics, Tomsk Research Medical Center,
- Siberian State Medical University, Ministry of Health of Russia,
- Regional Perinatal Center
- Issue: No 4 (2017)
- Pages: 14-20
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247872
- DOI: https://doi.org/10.18565/aig.2017.4.14-20
- ID: 247872
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Abstract
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About the authors
Ekaterina Aleksandrovna Trifonova
Research Institute of Medical Genetics, Tomsk Research Medical Center,
Email: ekaterina.trifonova@medgenetics.ru
Candidate of Medical Science, Research Associate
Olga Aleksandrovna Ganzha
Research Institute of Medical Genetics, Tomsk Research Medical Center,
Email: ganzha.olga42@gmail.com
a resident of the State Public Health Service
Tatyana Vasilievna Gabidulina
Siberian State Medical University, Ministry of Health of Russia,
Email: helen556@yandex.ru
MD, associate professor of the obstetrics and gynecology department
Larisa Leonidovna Devyatyarova
Regional Perinatal Center
Email: dev-larisa@yandex.ru
obstetrician-gynecologist
Larisa Stepanovna Sotnikova
Siberian State Medical University, Ministry of Health of Russia,
Email: sotnikova-larisa@mail.ru
MD, Professor of the Department of Obstetrics and Gynecology
Vadim Anatolyevich Stepanov
Research Institute of Medical Genetics, Tomsk Research Medical Center,
Email: vadim.stepanov@medgenetics.ru
Doctor of Biological Sciences, Professor, Director
References
- Сидельникова В.М., Сухих Г.Т. Невынашивание беременности. М.: ГЭОТАР-Медиа; 2010. 534с. [Sidelnikova V.M., Sukhikh G.T. Unintention of pregnancy. Moscow: GEOTAR-Media; 2010. 534p. (in Russian)]
- Радзинский В.Е., Соловьева А.В., Оленев А. С. Невынашивание беременности. Что в перспективе? Репродуктивная медицина. 2014; 3-4: 8-10. [Radzinsky V.E., Solovyova A.V., Olenev A.S. Unintention of pregnancy. What in the future? Reproductive medicine. 2014; 3-4: 8-10. (in Russian)]
- Rull K., Nagirnaja L., Laan M. Genetics of recurrent miscarriage: challenges, current knowledge, future directions. Front. Genet. 2012; 3: 34.
- Sergi C., Al Jishi T., Walker M. Factor V Leiden mutation in women with early recurrent pregnancy loss: a meta-analysis and systematic review of the causal association. Arch. Gynecol. Obstet. 2015; 291(3): 671-9. doi: 10.1007/s00404- 014-3443-x.
- Kolte A.M., Nielsen H.S., Steffensen R., Crespi B., Christiansen O.B. Inheritance of the 8.1 ancestral haplotype in recurrent pregnancy loss. Evol. Med. Public Health. 2015; (1): 325-31. doi: 10.1093/emph/eov031.
- Schulze R. Meta-analysis: a comparision of approaches. Cambridge, MA: Hogrefe & Huber; 2004. 242p.
- Nair R.R., Khanna A., Singh K. Association of GSTT1 and GSTM1 polymorphisms with early pregnancy loss in an Indian population and a meta-analysis. Reprod. Biomed. Online. 2013; 26(4): 313-22. doi: 10.1016/j.rbmo.2012.12.004.
- Ren A., Wang J. Methylenetetrahydrofolate reductase C677T polymorphism and the risk of unexplained recurrent pregnancy loss: a meta-analysis. Fertil. Steril. 2006; 86(6): 1716-22. doi: 10.1016/j.fertnstert.2006.05.052.
- Cao Y., Xu J., Zhang Z., Huang X., Zhang A., Wang J. et al. Association study between methylenetetrahydrofolate reductase polymorphisms and unexplained recurrent pregnancy loss: a meta-analysis. Gene. 2013; 514(2): 105-11. doi: 10.1016/j.gene.2012.10.091.
- Chen H., Yang X., Lu M. Methylenetetrahydrofolate reductase gene polymorphisms and recurrent pregnancy loss in China: a systematic review and meta-analysis. Arch. Gynecol. Obstet. 2016; 293(2): 283-90. doi: 10.1007/ s00404-015-3894-8.
- Nair R.R., Khanna A., Singh R., Singh K. Association of maternal and fetal MTHFR A1298C polymorphism with the risk of pregnancy loss: a study of an Indian population and a meta-analysis. Fertil. Steril. 2013; 99(5): 1311-8. e4. doi: 10.1016/j.fertnstert.2012.12.027.
- Gao H., Tao F.B. Prothrombin G20210A mutation is associated with recurrent pregnancy loss: a systematic review and meta analysis update. Thromb. Res. 2015; 135(2): 339-46. doi: 10.1016/ j.thromres.2014.12.001.
- Li J., Wu H., Chen Y., Wu H., Xu H., Li L. Genetic association between FXIII and ß-fibrinogen genes and women with recurrent spontaneous abortion: a meta- analysis. J. Assist. Reprod. Genet. 2015; 32(5): 817-25. doi: 10.1007/ s10815-015-0471-9.
- Wang X., Jiang W., Zhang D. Association of 14-bp insertion/deletion polymorphism of HLA-G gene with unexplained recurrent spontaneous abortion: a meta-analysis. Tissue Antigens. 2013; 81(2): 108-15. doi: 10.1111/ tan.12056.
- Agrawal S., Parveen F., Faridi R.M., Prakash S. Interleukin-1 gene cluster variants and recurrent pregnancy loss among North Indian women: retrospective study and meta-analysis. Reprod. Biomed. Online. 2012; 24(3): 342-51. doi: 10.1016/j.rbmo.2011.11.021.
- Nair R.R., Khanna A., Singh K. Association of interleukin 1 receptor antagonist (IL1RN) gene polymorphism with recurrent pregnancy loss risk in the North Indian Population and a meta-analysis. Mol. Biol. Rep. 2014; 41(9): 5719-27. doi: 10.1007/s11033-014-3443-8.
- Medica I., Ostojic S., Pereza N., Kastrin A., Peterlin B. Association between genetic polymorphisms in cytokine genes and recurrent miscarriage - a metaanalysis. Reprod. Biomed. Online. 2009; 19(3): 406-14.
- Bombell S., McGuire W. Cytokine polymorphisms in women with recurrent pregnancy loss: meta-analysis. Aust. N. Z. J. Obstet. Gynaecol. 2008; 48(2): 147-54. doi: 10.1111/j.1479-828X.2008.00843.x.
- Chen H., Yang X., Du J., Lu M. Interleukin-18 gene polymorphisms and risk of recurrent pregnancy loss: A systematic review and meta-analysis. J. Obstet. Gynaecol. Res. 2015; 41(10): 1506-13. doi: 10.1111/jog.12800.
- Zhang B., Liu T., Wang Z. Association of tumor necrosis factor-а gene promoter polymorphisms (-308G/A, -238G/A) with recurrent spontaneous abortion: a meta-analysis. Hum. Immunol. 2012; 73(5): 574-9. doi: 10.1016/j. humimm.2012.01.008.
- Li H.H., Xu X.H., Tong J., Zhang K.Y., Zhang C., Chen Z.J. Association of TNF-а genetic polymorphisms with recurrent pregnancy loss risk: a systematic review and meta-analysis. Reprod. Biol. Endocrinol. 2016; 14: 6. doi: 10.1186/ s12958-016-0140-6.
- Su M.T., Lin S.H., Chen Y.C. Association of sex hormone receptor gene polymorphisms with recurrent pregnancy loss: a systematic review and meta-analysis. Fertil. Steril. 2011; 96(6): 1435-44. e1. doi: 10.1016/j.fertn-stert.2011.09.030.
- Yang C., Fangfang W., Jie L., Yanlong Y., Jie W., Xuefei L. et al. Angiotensinconverting enzyme insertion/deletion (I/D) polymorphisms and recurrent pregnancy loss: a meta-analysis. J. Assist. Reprod. Genet. 2012; 29(11): 1167-73. doi: 10.1007/s10815-012-9870-3.
- Wang Z., Wang P., Wang X., He X., Wang Z., Xu D. et al. Significant association between angiotensin-converting enzyme gene insertion/deletion polymorphism and risk of recurrent miscarriage: a systematic review and meta-analysis. Metabolism. 2013; 62(9): 1227-38. doi: 10.1016/j.metabol.2013.03.003.
- Su M.T., Lin S.H., Chen Y.C., Kuo P.L. Genetic association studies of ACE and PAI-1 genes in women with recurrent pregnancy loss: a systematic review and meta-analysis. Thromb. Haemost. 2013; 109(1): 8-15. doi: 10.1160/TH12-08-0584.
- Pereza N., Ostojic S., Zdravcevic M., Volk M., Kapovic M., Peterlin B. Insertion/ deletion polymorphism in intron 16 of ACE gene in idiopathic recurrent spontaneous abortion: case-control study, systematic review and meta-analysis. Reprod. Biomed. Online. 2016; 32(2): 237-46. doi: 10.1016/j.rbmo.2015.11.003.
- Su M.T., Lin S.H., Chen Y.C. Genetic association studies of angiogenesis- and vasoconstriction-related genes in women with recurrent pregnancy loss: a systematic review and meta-analysis. Hum. Reprod. Update. 2011; 17(6): 803 12. doi: 10.1093/humupd/dmr027
- Cao Y., Zhang Z., Xu J., Wang J., Yuan W., Shen Y. et al. Genetic association studies of endothelial nitric oxide synthase gene polymorphisms in women with unexplained recurrent pregnancy loss: a systematic and meta-analysis. Mol. Biol. Rep. 2014; 41(6): 3981-9. doi: 10.1007/s11033-014-3266-7.
- Pereza N., Peterlin B., Volk M., Kapovic M., Ostojic S. A critical update on endothelial nitric oxide synthase gene variations in women with idiopathic recurrent spontaneous abortion: genetic association study, systematic review and meta-analyses. Mol. Hum. Reprod. 2015; 21(5): 466-78. doi: 10.1093/molehr/ gav008.
- Tang W., Zhou X., Chan Y., Wu X., Luo Y. p53 codon 72 polymorphism and recurrent pregnancy loss: a meta-analysis. J. Assist. Reprod. Genet. 2011; 28(10): 965-9. doi: 10.1007/s10815-011-9618-5.
- Chen H., Yang X., Wang Z. Association between p53 Arg72Pro polymorphism and recurrent pregnancy loss: an updated systematic review and meta-analysis. Reprod. Biomed. Online. 2015; 31(2): 149-53. doi: 10.1016/j.rbmo.2015.05.003.
- Chen H., Nie S., Lu M. Association between plasminogen activator inhibitor-1 gene polymorphisms and recurrent pregnancy loss: a systematic review and meta-analysis. Am. J. Reprod. Immunol. 2015; 73(4): 292-300. doi: 10.1111/ aji.12321.
- Li X., Liu Y., Zhang R., Tan J., Chen L., Liu Y. Meta-analysis of the association between plasminogen activator inhibitor-1 4G/5G polymorphism and recurrent pregnancy loss. Med. Sci. Monit. 2015; 21: 1051-6. doi: 10.12659/MSM.892898.
- Zhang B., Dai B., Zhang X., Wang Z. Vascular endothelial growth factor and recurrent spontaneous abortion: a meta-analysis. Gene. 2012; 507(1): 1-8. doi: 10.1016/j.gene.2012.06.049.
- Xu X., Du C., Li H., Du J., Yan X., Peng L. et al. Association of VEGF genetic polymorphisms with recurrent spontaneous abortion risk: a systematic review and meta-analysis. PLoS One. 2015; 10(4): e0123696. doi: 10.1371/journal. pone.0123696.
- Трифонова Е.А., Габидулина Т.В., Агаркова Т.А., Габитова Н.А., Степанов В.А. Гомоцистеин, полиморфизмы гена MTHFR и осложнения беременности. Акушерство и гинекология. 2011; 2: 8-15. [Trifonova E.A., Gabidulina T.V., Agarkova T.A., Gabitova N.A., Stepanov V.A. Homocysteine, MTHFR gene polymorphisms, and pregnancy complications. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2011; (2): 8-15. (in Russian)
- Трифонова Е.А., Габидулина Т.В., Бухарина И.Ю., Степанов В.А. Роль факторов наследственной предрасположенности в развитии преэклампсии: обзор данных мета-анализов. Молекулярная медицина. 2016; 1: 8-14. [Trifonova E.A., Gabidulina T.V., Buharina I.Yu., Stepanov V.A. The role of factors of hereditary predisposition in the development of pre-eclampsia: an overview of meta-analysis data. Molekulyarnaya meditsina. 2016; 1: 8-14. (in Russian)]
- Ramön L.A., Gilabert-Estellés J., Cosin R., Gilabert J., Espana F., Castelló R. et al. Plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism and endometriosis. Influence of PAI-1 polymorphism on PAI-1 antigen and mRNA expression. Thromb. Res. 2008; 122(6): 854-60.
- Serrano N.C., Díaz L.A., Páez M.C., Mesa C.M., Cifuentes R., Monterrosa A. et al. Angiotensin-converting enzyme I/D polymorphism and pre-eclampsia risk: evidence of small-study bias. PLoS Med. 2006; 3(12): e520.
- Amirchaghmaghi E., Rezaei A., Moini A., Roghaei M.A., Hafezi M., Aflatoonian R. Gene expression analysis of VEGF and its receptors and assessment of its serum level in unexplained recurrent spontaneous abortion. Cell J. 2015; 16(4): 538-45.
- Galazios G., Papazoglou D., Tsikouras P., Kolios G. Vascular endothelial growth factor gene polymorphisms and pregnancy. J. Matern. Fetal Neonatal Med. 2009; 22(5): 371-8. doi: 10.1080/14767050802645035.
- Su M.T., Lin S.H., Chen Y.C., Kuo P.L. Gene-gene interactions and risk of recurrent miscarriages in carriers of endocrine gland-derived vascular endothelial growth factor and prokineticin receptor polymorphisms. Fertil. Steril. 2014; 102(4): 1071-7. e3. doi: 10.1016/j.fertnstert.2014.06.042.
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