Genetic factors in the development of recurrent miscarriage: An overview of the data of meta-analyses


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Objective. The review highlights the issues associated with a study of the role of genetic components in recurrent miscarriage (RM) susceptibility through generalized quantitative analysis of data. Material and methods. The review includes the results of foreign and Russian meta-analyses published in the past 10 years and found in the Pubmed database on this topic. Results. The data obtained from the meta-analyses of studies of an association of allelic variants of candidate genes with RM were generalized and the functional signif icance of a number of associated polymorphic markers was characterized. Consideration of the ethnicity of individuals was shown to be important in studying the role of genetic factors in the development of this disease, as well as gene-gene and gene-environmental interactions. Conclusion. Creation of a future database including the results of associative studies with a detailed description of their design (detailed clinical characteristics of the examinees; criteria for group formations; patient ethnicity) will provide statistically significant evidence for the role of genetic components in the structure of RM susceptibility.

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作者简介

Ekaterina Trifonova

Research Institute of Medical Genetics, Tomsk Research Medical Center,

Email: ekaterina.trifonova@medgenetics.ru
Candidate of Medical Science, Research Associate

Olga Ganzha

Research Institute of Medical Genetics, Tomsk Research Medical Center,

Email: ganzha.olga42@gmail.com
a resident of the State Public Health Service

Tatyana Gabidulina

Siberian State Medical University, Ministry of Health of Russia,

Email: helen556@yandex.ru
MD, associate professor of the obstetrics and gynecology department

Larisa Devyatyarova

Regional Perinatal Center

Email: dev-larisa@yandex.ru
obstetrician-gynecologist

Larisa Sotnikova

Siberian State Medical University, Ministry of Health of Russia,

Email: sotnikova-larisa@mail.ru
MD, Professor of the Department of Obstetrics and Gynecology

Vadim Stepanov

Research Institute of Medical Genetics, Tomsk Research Medical Center,

Email: vadim.stepanov@medgenetics.ru
Doctor of Biological Sciences, Professor, Director

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