Serum levels of growth factors (PlGF, PDGF-BB, VEGF-A) in women with infertility and miscarriage associated with chronic endometritis
- Authors: Kometova V.V.1, Kozyreva E.V.2, Davidyan L.Y.3, Malanina E.N.2, Bogdasarov A.U.3, Voznesenskaya N.V.3
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Affiliations:
- Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
- Ulyanovsk Regional Clinical Hospital
- Ulyanovsk State University
- Issue: No 4 (2017)
- Pages: 74-80
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247886
- DOI: https://doi.org/10.18565/aig.2017.4.74-80
- ID: 247886
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Abstract
Objective. To justify the diagnostic and prognostic value of the serum levels of placental growth factor (PIGF), platelet-derived growth factor (PDGF-BB), and vascular endothelial growth factor (VEGF-A) in women with infertility and/or miscarriage due to chronic endometritis. Subjects and methods. A comprehensive examination was made in 88 women who were divided into the following clinical groups: 1) 28 women with recurrent pregnancy loss and morphologically and immunohistochemically confirmed chronic endometritis; 2) 36 infertile patients with chronic endometritis; 3) 24 women with male factor infertility and unchanged endometrial structure (a control group). The investigators performed clinical (history data collection, general and gynecological examinations) and ultrasound studies on days 15-22 of the menstrual cycle, aspiration and Pipelle biopsies of the endometrium on days 7-11 of the menstrual cycle, and enzyme immunoassay of serum PlGF, PDGF-BB, and VEGF-A levels. Results. PlGF and VEGF were increased and PDGF-BB was decreased in the serum of the women in Groups 1 and 2. Conclusion. The above results can be used in clinical practice. The determination of PIGF and VEGF-A levels is one of the promising methods for evaluating the endometrium.
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About the authors
Vlada Vladimirovna Kometova
Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: vladastasiatema@mail.ru
PhD, senior researcher
Elena Vladimirovna Kozyreva
Ulyanovsk Regional Clinical Hospital
Email: miss_smile_777@mail.ru
PhD, obstetrician-gynecologist
Liana Yuryevna Davidyan
Ulyanovsk State University
Email: a.bogdasarov@mail.ru
MD, professor of the Faculty of postgraduate medical and pharmaceutical education
Ekaterina Nikolaevna Malanina
Ulyanovsk Regional Clinical Hospital
Email: malaninaekaterina@mail.ru
PhD, doctor of ultrasonic diagnostics
Azat Urievich Bogdasarov
Ulyanovsk State University
Email: a.bogdasarov@mail.ru
MD, professor, chief physician of the medical center „My doctor”
Nadezhda Vadimovna Voznesenskaya
Ulyanovsk State University
Email: vnadezda@list.ru
PhD, assistant professor, Department of Obstetrics and Gynecology
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