Serum levels of growth factors (PlGF, PDGF-BB, VEGF-A) in women with infertility and miscarriage associated with chronic endometritis


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Abstract

Objective. To justify the diagnostic and prognostic value of the serum levels of placental growth factor (PIGF), platelet-derived growth factor (PDGF-BB), and vascular endothelial growth factor (VEGF-A) in women with infertility and/or miscarriage due to chronic endometritis. Subjects and methods. A comprehensive examination was made in 88 women who were divided into the following clinical groups: 1) 28 women with recurrent pregnancy loss and morphologically and immunohistochemically confirmed chronic endometritis; 2) 36 infertile patients with chronic endometritis; 3) 24 women with male factor infertility and unchanged endometrial structure (a control group). The investigators performed clinical (history data collection, general and gynecological examinations) and ultrasound studies on days 15-22 of the menstrual cycle, aspiration and Pipelle biopsies of the endometrium on days 7-11 of the menstrual cycle, and enzyme immunoassay of serum PlGF, PDGF-BB, and VEGF-A levels. Results. PlGF and VEGF were increased and PDGF-BB was decreased in the serum of the women in Groups 1 and 2. Conclusion. The above results can be used in clinical practice. The determination of PIGF and VEGF-A levels is one of the promising methods for evaluating the endometrium.

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About the authors

Vlada Vladimirovna Kometova

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: vladastasiatema@mail.ru
PhD, senior researcher

Elena Vladimirovna Kozyreva

Ulyanovsk Regional Clinical Hospital

Email: miss_smile_777@mail.ru
PhD, obstetrician-gynecologist

Liana Yuryevna Davidyan

Ulyanovsk State University

Email: a.bogdasarov@mail.ru
MD, professor of the Faculty of postgraduate medical and pharmaceutical education

Ekaterina Nikolaevna Malanina

Ulyanovsk Regional Clinical Hospital

Email: malaninaekaterina@mail.ru
PhD, doctor of ultrasonic diagnostics

Azat Urievich Bogdasarov

Ulyanovsk State University

Email: a.bogdasarov@mail.ru
MD, professor, chief physician of the medical center „My doctor”

Nadezhda Vadimovna Voznesenskaya

Ulyanovsk State University

Email: vnadezda@list.ru
PhD, assistant professor, Department of Obstetrics and Gynecology

References

  1. Akopians A.L., Pisarska M.D., Wang E.T. The role of inflammatory pathways in implantation failure: chronic endometritis and hydrosalpinges. Semin. Reprod. Med. 2015; 33(4): 298-304. doi: 10.1055/s-0035-1554916.
  2. Kasius J.C., Fatemi H.M., Bourgain C., Sie-Go D.M., Eijkemans R.J., Fauser B.C. et al. The impact of chronic endometritis on reproductive outcome. Fertil. Steril. 2011; 96(6): 1451-6. doi: 10.1016/j.fertnstert.2011.09.039.
  3. Сухих Г.Т., Шуршалина А.В. Хронический эндометрит. Руководство. М.: ГЭОТАР-Медиа; 2013. 64с. [Sukhikh G.T., Shurshalina A.V. Chronic endometritis. Guideline. Moscow: GEOTAR-Media; 2013. 64p. (in Russian)]
  4. Kitaya K., Matsubayashi H., Yamaguchi K., Nishiyama R., Takaya Y., Ishikawa T. et al. Chronic endometritis: potential cause of infertility and obstetric and neonatal complications. Am. J. Reprod. Immunol. 2016; 75(1): 13-22. doi: 10.1111 / aji.12438.
  5. Базина М.И., Егорова А.Т., Ходорович Н.А., Сыромятникова С.А., Киреченко А.К., Хоржевский В.А. Хронический эндометрит: скрытая угроза репродукции. Доктор.Ру. 2015; 14: 20-7. [Bazina M.I., Egorova A.T., Khodorovich N. A., Syromyatnikova S.A., Kirichenko A. K., Khorzhevskii V.A. Chronic endometritis: a hidden threat of reproduction. Doktor.Ru. 2015; 14: 20-7. (in Russian)]
  6. Resta L., Palumbo M., Rossi R., Piscitelli D., Grazia Fiore M., Cicinelli E. Histology of micro polyps in chronic endometritis. Histopathology. 2012; 60(4): 670-4. doi: 10.1111/j.1365-2559.2011.04099.x.
  7. Овчарук Э.А. Хронический аутоиммунный эндометрит как одна из главных причин нарушения рапродуктивной функции (обзор литературы). Вестник новых медицинских технологий. Электронное издание. 2013; 20(1): 224. Avaiable at: http://medtsu.tula.ru/VNMT/Bulletin/E2013-1/4664. pdf (Accessed January 2013). [Ovcharuk E.A. Chronic autoimmune endometritis as one of the main causes of impaired reproductive function (literature review). Vestnik novykh meditsinskikh tekhnologii. Electronic Edition. 2013; 20(1): 224. Avaiable at: http://medtsu.tula.ru/VNMT/Bulletin/E2013-1/4664.pdf (Accessed January 2013). (in Russian)]
  8. Нефедова Н.А., Давыдова С.Ю. Роль сосудистого эндотелиального фактора роста (VEGF) и гипоксия-индуцибельного фактора (HIF) в опухолевом ангиогенезе. Современные проблемы науки и образования. 2015; 3: 51. Avaiable at: http://www.science-education.ru/ru/article/view?id=17924 (Accessed 18 March 2015). [Nefedova N.A., Davydova S.Yu. The role of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor (HIF) in tumor angiogenesis. Sovremennye problemy nauki i obrazovaniya. 2015; 3: 51. Avaiable at: http://www.science-education.ru/ru/article/view?id=17924 (Accessed 18 March 2015). in Russian)]
  9. Козырева Е.В., Давидян Л.Ю. Роль факторов роста в генезе бесплодия и невынашивания беременности (обзор литературы). Современные проблемы науки и образования. 2015; 4: 444. Avaiable at: http://www. science-education.ru/ru/article/view?id=20811 (Accessed 24 July 2015). [Kozyreva E.V., Davidyan L.Yu. The role of growth factors in the genesis of infertility and miscarriage (literature review). Sovremennye problemy nauki i obrazovaniya. 2015; 4: 444. Avaiable at: http://www. science-education.ru/ru/article/view?id=20811 (Accessed 24 July 2015). (in Russian)]
  10. Хашукоева А.З., Водяник Н.Д., Хлынова С.А., Цомаева Е.А. Хронический эндометрит - проблема и решения. Лечащий врач. 2012; 2: 42. Avaiable at: http://www.lvrach.ru/2012/03/15435375/ (Accessed March 2012). [Khashukoeva AZ., Vodyanik N.D., Khlynova S.A., Tsomaeva E.A. Chronic endometritis - problem and solutions. Lechashchii vrach. 2012; 2: 42. Avaiable at: http://www.lvrach.ru/2012/03/15435375/ (Accessed March 2012). (in Russian)]
  11. Kitaya K., Yasuo T. Immunohistochemistrical and clinicopathological characterization of chronic endometritis. Am. J. Reprod. Immunol. 2011; 66(5): 410-5. doi: 10.1111/j.1600-0897.2011.01051.x. [Kitaya K., Yasuo T. Immunohistochemistrical and clinicopathological characterization of chronic endometritis. Am J Reprod Immunol. 2011; 66(5): 410-5. doi: 10.1111/j.1600-0897.2011.01051.x.]
  12. McQueen D.B., Perfetto C.O., Hazard F.K., Lathi R.B. Pregnancy outcomes in women with chronic endometritis and recurrent pregnancy loss. Fertil. Steril. 2015; 104(4): 927-31. doi: 10.1016/j. fertnstert.2015.06.044. [McQueen D.B., Perfetto C.O., Hazard F.K., Lathi R.B. Pregnancy outcomes in women with chronic endometritis and recurrent pregnancy loss. Fertil Steril. 2015;104(4): 927-31. doi: 10.1016/ j.fertnstert.2015.06.044.]
  13. Краснопольский В.И., Логутова Л.С., Зароченцева Н.В., Дуб Н.В., Титченко Ю.П., Овчинникова В.В., Меньшикова Н.С., Аршакян А.К., Ушакова С.В. Прегравидарная подготовка женщин с невынашиванием беременности и хроническим эндометритом. Учебное пособие. СПб.; 2014. 31с. [Krasnopolskiy V.I., Logutova L.S., Zarochentseva N.V., Dub N.V., Titchenko Yu.P., Ovchinnikova V.V., Menshikova N.S., Arshakyan A.K., Ushakova S.V. Pre-education training for women with miscarriage and chronic endometritis. Tutorial. St. Petersburg; 2014. 31p. (In Russian)]
  14. Захарова Н.Б., Дурнов Д.А., Михайлов В.Ю., Понукалин А.Н., Никитина В.В., Занкина О.В., Леонова М.Л. Диагностическое значение исследования фактора роста эндотелия сосудов в сыворотке крови. Фундаментальные исследования. 2011; 11-1: 215-20. [Zakharova N.B., Durnov D.A., Mikhailov V.Yu., Ponukalin A.N., Nikitina V.V., Zankina O.V., Leonova M.L. Diagnostic value of the study of the growth factor of the vascular endothelium in blood serum. Fundamental’nye issledovaniya. 2011; 11: 215-20. (in Russian)]

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