PLACENTAL MITOCHONDRIA IN HEALTH AND IN PREECLAMPSIA


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Abstract

Objective. To analyze the data available in modern scientific literature on the relationship between preeclampsia and the mitochondrial reticulum. Materials and methods. The review included the data available in international peer-reviewed databases. Both works of pioneers in this area and contemporary publications on the topic in question were considered. Results. The paper describes the basic mechanisms of mitochondrial involvement in the development of preeclampsia, such as cell redox reaction imbalance, apoptotic death, mitochondrial DNA mutations, and structural changes in the mitochondrial reticulum. Conclusion. Oxidative stress observed in maternal preeclampsia results from complex dysfunction in the mitochondrial reticulum that needs to be thoroughly and comprehensively investigated.

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About the authors

Polina Alexandrovna VISHNYAKOVA

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: p_vishnyakova@oparina4.ru
Researcher, Laboratory of Mitochondrial Medicine

Natalia Enkynovna KAN

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: kan-med@mail.ru
MD, head of Obstetric Observational Department

Zulfiya Sagdullaevna KHODZHAEVA

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: z_khodzhaeva@mail.ru
MD, professor, senior researcher

Mikhail Yur'evich VYSOKIKH

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: m_vysokikh@oparina4.ru
Candidate of Biological Sciences, Head of the Laboratory of Mitochondrial Medicine

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