Pregnancy after solid organ transplantation: Complications, outcomes, prospects


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Abstract

Objective. To carry out a systematic analysis of the data available in the current literature, which reflect the state of the problem of pregnancy after solid organ transplantation worldwide. Materials and methods. The review includes the data of foreign and Russian articles published in the past 14 years and found in Pubmed on this topic. Results. The paper describes the impact of immunosuppressive therapy on fertility, a developing fetus, and graft function. It presents the latest results of investigations dealing with breastfeeding in the use of immunosuppressive agents, as well as the obtained data on the health status of infants born to mothers with transplanted organs. Conclusion. Posttransplantation pregnancy is associated with a high risk of complications for both mother and fetus. The integrated approach applied by obstetricians/gynecologists, immunologists, and transplantologists to this patient group reduces maternal and reproductive losses. It is necessary to conduct further studies aimed at investigating of the long-term consequences of the intrauterine effect of immunosuppressive therapy on the developing fetus.

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About the authors

Ekaterina Aleksandrovna Shatalova

Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: e_shatalova@oparina4.ru
post-graduate student of the Department of Anesthesiology and Intensive Care of Newborns

Victor Vasilievich Zubkov

Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: v_zubkov@oparina4.ru
doctor of medical sciences, head of the department of neonatology and pediatrics

Roman Georgievich Shmakov

Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: r_shmakov@oparina4.ru
Doctor of Medicine, Chief Physician

Julia Leonidovna Podurovskaya

Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: y_podurovskaya@oparina4.ru
Candidate of Medical Sciences, Head of the Department of Neonatal Surgery

Natalia Fedorovna Kravchenko

Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: n_kravchenko@oparina4.ru
Candidate of Medical Sciences, Senior Researcher of the 1st Obstetric Department of the Pathology of Pregnancy

Lyudmila Viktorovna Vanko

Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: l_Vanko@oparina4.ru
Doctor of Medicine

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