Neoadjuvant chemotherapy and laparoscopic radical hysterectomy for locally advanced cervical cancer


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Abstract

Objective. To investigate the efficiency of neoadjuvant chemotherapy in combination with laparoscopic radical hysterectomy in the combination treatment of patients with locally advanced cervical cancer. Subjects and methods. The results of examining 81 patients with locally advanced cervical cancer who had received combination treatment involving neoadjuvant chemotherapy and surgical treatment are given. Results. Following neoadjuvant chemotherapy, radical hysterectomy was performed in 75 (92.6%) patients. The surgical interventions via laparoscopic and laparotomic accesses were comparatively analyzed and yielded the similar results.

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About the authors

Dmitry L. Ovodenko

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: d_ovodenko@oparina4.ru
PhD, oncogynecologist, Department of combined and integrated methods of treatment of gynecological diseases

Gregory N. Khabas

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: g_khabas@oparina4.ru
MD, Ph.D., head of the Department of combined and integrated methods of treatment of gynecological diseases

Olga I. Aleshikova

Russian Research Center of Roentgenology and Radiology, Ministry of Health of Russia

Email: olga.aleshikova@gmail.com
PhD, Senior Scientist Laboratory early carcinogenesis, prevention, diagnosis and combined treatment of cancer of the female reproductive organs

Sophiko L. Vashakmadze

Russian Research Center of Roentgenology and Radiology, Ministry of Health of Russia

Email: v.sofla.l@gmail.com
graduate student of the department of early carcinogenesis, prevention, diagnosis and combined treatment of cancer of the female reproductive organs

Maria S. Pirogova

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: m_pirogova@oparina4.ru
oncologist of the Department of Breast Pathology

Maya V. Sannikova

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: m_sannikova@oparina4.ru,mvs6l03@gmail.com
PhD, researcher at the Department of combined and integrated methods of treatment of gynecological diseases

Anna S. Makarova

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

doctor obstetrician-gynecologist, department of innovative oncology and gynecology

Polina L. Sheshko

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: p_sheshko@oparina4.ru
obstetrician-gynecologist, oncologist of the Department of Innovative Oncology and Gynecology

Alexey A. Korshunov

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_korshunov@oparina4.ru
obstetrician-gynecologist, Department of combined and integrated methods of treatment of gynecological diseases

Lev A. Ashrafyan

Russian Research Center of Roentgenology and Radiology, Ministry of Health of Russia

Email: levaa2004@yahoo.com
Corresponding Member of the Russian Academy of Sciences, Professor, MD, director of early carcinogenesis, prevention, diagnosis and combined treatment of cancer of the female reproductive organs

References

  1. Armstrong E.P. Prophylaxis of eervical eancer and related cervical disease: a review of the cost-effectiveness of vaccination against oncogenic HPV types. J. Manag. Care Pharm. 2010; 16(3): 217-30. [
  2. Ferlay J., Bray F., Pisani P., Parkin D.M. GLOBOCAN 2002 Cancer incidence, mortality and prevalence worldwide. Lyon: IARC CancerBase; 2004.
  3. Каприн А.Д., Старинский В.В., Петрова Г.В., ред. Злокачественные новообразования в России в 2012 году (заболеваемость и смертность). М.: МНИОИ им. П.А. Герцена - филиал ФГБУ «ФМИЦ им. П.А. Герцена» Минздрава России; 2014. [Kaprin A.D., Starinskiy V.V., Petrova G.V., ed. Malignant neoplasms in Russia in 2012 (morbidity and mortality). Moscow: MNIOI im. P.A. Herzen - a branch of the FGBU „FMIc. P.A. Herzen „of the Russian Ministry of Health; 2014. (in Russian)]
  4. Denny L. Cervical cancer: the South African perspective. FIGO 6th Annual Report on the Results of Treatment in Gynecological Cancer. Int. J. Gynaecol. Obstet. 2006; 95(Suppl. 1): S211-4.
  5. Бохман Я.В. Руководство по онкогинекологии. CTO.: Фолиант; 2002. [Bohman Ya.V. Guide to oncogynecology. St. Petersburg: Foliant; 2002. (in Russian)]
  6. Квеладзе В.В. Многокомпонентное лечение больных с местнораспространенным раком шейки матки в условиях индукционной полихимиотерапии: дисс.. канд. мед. наук. Челябинск; 2005. [Kveladze V.V. Multicomponent treatment of patients with locally advanced cervical cancer under induction polychemotherapy. Diss. Chelyabinsk; 2005. (in Russian)]
  7. Коломиец Л.А., Чуруксаева О.Н. Роль химиотерапии в лечении местнораспространенных форм рака шейки матки. Сибирский онкологический журнал. 2006; 1: 61-3. [Kolomiets L.A., Churuksaeva O.N. Role of chemotherapy in the treatment of locally advanced forms of cervical cancer. Sibirskiy onkologicheskiy zhurnal. 2006; 1: 61-3. (in Russian)]
  8. Кузнецов В.В., Лебедев А.И., Морхов А.А., Грицай А.Н. Хирургия инвазивного рака шейки матки. Практическая онкология. 2002; 3(3): 178-82. [Kuznetsov V.V., Lebedev A.I., Morhov A.A., Gritsay A.N. Surgery of invasive cervical cancer. Prakticheskaya onkologiya. 2002; 3(3): 178-82. (in Russian)]
  9. Вишневская Е.Е. Рак шейки матки. Минск: Беларусь; 1987. [Vishnevskaya E.E. Cervical cancer. Minsk: Belarus; 1987. (in Russian)]
  10. Козаченко В.П., ред. Клиническая онкогинекология. Руководство для врачей. М.: Медицина; 2005. 376с. [Kozachenko V.P., ed. Clinical oncogynecology. Guidelines for doctors. Moscow: Meditsina; 2005. 376p. (in Russian)]
  11. Винокуров В.Л. Рак шейки матки, тела матки и яичников: итоги и перспективы исследований в ЦНИРРИ Минздрава РФ. Вопросы онкологии. 2003; 49(5): 656-62. [Vinokurov V.L. Cancer of the cervix, the body of the uterus and ovaries: the results and prospects for research in the Central Research Institute of the Ministry of Health of the Russian Federation. Voprosyi onkologii. 2003; 49(5): 656-62. (in Russian)]
  12. Костромина К.Н. Современная стратегия лучевого лечения больных раком шейки матки. В кн.: Материалы научно-практической конференции «Роль лучевой терапии в гинекологической онкологии». Обнинск; 2002: 107-9. [Kostromina K.N. Modern strategy of radiation treatment of patients with cervical cancer. In: Materials of the scientific-practical conference „The role of radiotherapy in gynecological oncology”. Obninsk; 2002: 107-9. (in Russian)]
  13. Кравец О.А., Марьина Л.А., Чехонадский В.Н., Русанов А.О. Лучевая терапия местнораспространенного рака шейки матки. В кн.: Материалы научно-практической конференции «Роль лучевой терапии в гинекологической онкологии». Обнинск; 2002: 112-4. [Kravets O.A., Marina L.A., Chehonadskiy V.N., Rusanov A.O. Radiation therapy of locally advanced cervical cancer. In: Materials of the scientific-practical conference „The role of radiotherapy in gynecological oncology”. Obninsk; 2002: 112-4. (in Russian)]
  14. Крикунова Л.И. Лучевая терапия рака шейки матки. Практическая онкология. 2002; 3(3): 194-9. [Krikunova L.I. Radiation therapy of cervical cancer. Prakticheskaya onkologiya. 2002; 3(3): 194-9. (in Russian)]
  15. van Limbergen E. Научно-обоснованные рекомендации по проведению лучевой терапии при раке шейки матки. В кн.: Материалы Европейской школы онкологии. Семинар на Красной площади «Современные аспекты онкогинекологии». М.; 2009: 11-27. [van Limbergen E. Evidence-based recommendations for radiotherapy for cervical cancer. In: Materials of the European School of Oncology. Seminar on the Red Square „Modern aspects of oncogynecology”. Moscow; 2009: 11-27. (in Russian)]
  16. Горбунова В.В. Оптимизация сочетанной лучевой терапии местнораспространенного рака шейки матки и рецидивов рака яичников с химиотерапией в терапевтическом режиме: дисс.. д-ра мед. наук. М.; 2002. [Gorbunova V.V. Optimization of combined radiotherapy for locally advanced cervical cancer and recurrence of ovarian cancer with chemotherapy in the therapeutic regimen. Diss. Moscow; 2002. (in Russian)]
  17. Кандакова Е.Ю. Сочетанная лучевая терапия местнораспространенного рака шейки матки у больных репродуктивного возраста в условиях индукционной полихимиотерапии: дисс. канд. мед. наук. М.; 2001. [Kandakova E.Yu. Combined radiation therapy of locally advanced cervical cancer in patients of reproductive age under induction polychemotherapy. Diss. Moscow; 2001. (in Russian)]
  18. Benedetti Panici P., Bellati F., Manci N., Pernice M., Plotti F., Di Donato V. et al. Neoadjuvant chemotherapy followed by radical surgery in patients affected by FIGO stage IVA cervical cancer. Ann. Surg. Oncol. 2007; 14(9): 2643-8.
  19. Moore D.H. Neoadjuvant chemotherapy for cervical cancer. Expert Opin. Pharmacother. 2003; 4(6): 859-67.
  20. Ашрафян Л.А., Антонова И.Б., Алешикова О.И., Добровольская Н.Ю. Хирургический этап как один из основных компонентов в лечении рака шейки матки IIb-IIIb стадий. Российский онкологический журнал. 2007; 3: 21-5. [Ashrafyan L.A., Antonova I.B., Aleshikova O.I., Dobrovolskaya N.Yu. Surgical stage as one of the main components in the treatment of cervical cancer IIb-IIIb stages. Rossiyskiy onkologicheskiy zhurnal. 2007; 3: 21-5. (in Russian)]
  21. Ашрафян Л.А., Антонова И.Б., Алешикова О.И., Добровольская Н.Ю., Чазова Н.Л. Диагностические критерии и факторы прогноза эффективности неоадъюванной химиотерапии местно-распространенного рака шейки матки (IIb - IIIb стадии). Опухоли женской репродуктивной системы. 2007; 4: 63-71. [Ashrafyan L.A., Antonova I.B., Aleshikova O.I., Dobrovolskaya N.Yu., Chazova N.L. Diagnostic criteria and factors predicting the effectiveness of neoadjuvant chemotherapy for locally advanced cervical cancer (IIb - IIIb stage). Opuholi zhenskoy reproduktivnoy sistemyi. 2007; 4: 63-71. (in Russian)]
  22. Хатьков И.Е., Барсуков Ю.А., Атрощенко А.О., Алиев В.А., Кузьмичев Д.В., Тамразов Р.И., Гордеев С.С. История развития лапароскопической хирур гии. Онкологическая колопроктология. 2012; 2: 35-40. [Hatkov I.E., Barsukov Yu.A., Atroschenko A.O., Aliev V.A., Kuzmichev D.V., Tamrazov R.I., Gordeev S.S. History of the development of laparoscopic surgery. Onkologicheskaya koloproktologiya. 2012; 2: 35-40. (in Russian)]
  23. Salicru S., Gil-Moreno A., Montero A., Roure M., Perez-Benavente A., Xercavins J. Laparoscopic radical hysterectomy with pelvic lymphadenectomy in early invasive cervical cancer. J. Minim. Invasive Gynecol. 2011; 18(5): 555-68.
  24. Terai Y., Tanaka T., Sasaki H., Kawaguchi H., Fujiwara S., Yoo S. et al. Total laparoscopic modified radical hysterectomy with lymphadenectomy for endometrial cancer compared with laparotomy. J. Obstet. Gynaecol. Res. 2014; 40(2): 570-5.
  25. Jennings T.S., Dottino P., Rahaman J., Cohen C.J. Results of selective use of operative laparoscopy in gynecologic oncology. Gynecol. Oncol. 1998; 70(3): 323-8.
  26. Querleu D., Leblanc E., Martel P., Ferron G., Narducci F. Lymph node dissection in the surgical management of stage I endometrial carcinomas. Gynecol. Obstet. Fertil. 2003; 31(12): 1004-12.
  27. Eisenhauer E.A., Therasse P., Bogaerts J., Schwartz L.H., Sargent D., Ford R. et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur. J. Cancer. 2009; 45(2): 228-47.
  28. Piver M.S., Rutledge F., Smith J.P. Five classes of extended hysterectomy for women with cervical cancer. Obstet. Gynecol. 1974; 44(2): 265-72.
  29. Querleu D., Morrow C.P. Classification of radical hysterectomy. Gynecol. Oncol. 2009; 115(2): 314-5; author reply 315-6.
  30. Кравец А., Кузнецов В.В., Морхов К.Ю., Нечушкина В.М., Хохлова С.В. Клинические рекомендации по диагностике и лечению рака шейки матки. М.: Ассоциация онкологов России; 2014. [Kravets A., Kuznetsov V.V., Morhov K.Yu., Nechushkina V.M., Hohlova S.V. Clinical recommendations for the diagnosis and treatment of cervical cancer. Moscow: Association of Russian Oncologists; 2014. (in Russian)]
  31. Landoni F., Sartori E., Maggino T., Zola P., Zanagnolo V., Cosio S. et al. Is there a role for postoperative treatment in patients with stage Ib2-IIb cervical cancer treated with neo-adjuvant chemotherapy and radical surgery? An Italian multicenter retrospective study. Gynecol. Oncol. 2014; 132(3): 611-7.

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