Impact of influenza vaccination on the course of pregnancy and on fetal and neonatal development


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Abstract

Objective. To carry out a systematic analysis of the data available in the current literature on the impact of influenza vaccination on the course of pregnancy and on fetal and neonatal development. To comparatively analyze the effects of subunit non-adjuvanted and subunit immunoadjuvant influenza vaccines on increases in the titer of antibodies against influenza virus strains in mother-neonate pairs with regard to the trimester of pregnancy. Material and methods. The review includes the current and topical materials of foreign and Russian investigators from the MEDLINE database in the past 10years. Results. Inactivated subunit influenza vaccines administered in the second and third trimesters of pregnancy have been found to have no impact on the course of pregnancy, the development of a fetus and a baby within first 6 months of life and to result in the synthesis of antibodies that can protect not only the vaccinated women, but also their infants during the first 3 to 5 months of life. Conclusion. Influenza vaccination with inactivated subunit vaccines in the second and third trimesters of pregnancy is a safe and effective method to protect both pregnant women and their babies against influenza.

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About the authors

Ekaterina Aleksandrovna Khromova

I.I. Mechnikov Research Institute of Vaccines and Sera

Email: kate.khromova@mail.ru
junior researcher, post-graduate student

Elina Altafovna Akhmatova

I.M. Sechenov First Moscow State Medical University

Email: ela.150@yandex.ru
a student of the medical faculty of the Higher School of Economics

Aristika Mikhailovna Kostinova

Federal Biomedical Agency of Russia

Email: aristica_kostino@mail.ru
resident, Institute of Immunology

Alexander Petrovich Cherdantsev

Ulyanovsk State University

Email: a_cherdantsev@rambler.ru
MD, Professor of the Department of Pediatrics

Anna Alekseevna Savisko

Rostov State Medical University

Email: Annsav@mail.ru
Candidate of Medical Science, Associate Professor of the Department of Outpatient and Emergency Pediatrics

Nelli Kimovna Akhmatova

I.I. Mechnikov Research Institute of Vaccines and Sera

Email: anelly@mail.ru
MD, Head of the Laboratory of Immune Regulation Mechanisms

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