Placental PIBF1 gene mRNA expression during preterm labor


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Abstract

Objective. To investigate the role of a progesterone-induced blocking factor in the genesis of preterm labor. Subjects and methods. A comprehensive examination was made in 63 puerperas (34 with preterm labor and 29 with term labor). Results. There was evidence for the effects of micronizedprogesterone on placental PIBF1 gene mRNA expression. A direct correlation (correlation coefficient r = 0.66 (95% CI 0.22 to 1.12)) was found between plasma progesterone levels and placental PIBF1 gene mRNA expression. Patients with low PIBF1 gene mRNA expression were ascertained to have histological signs of placental insufficiency. Conclusion. In the presence of progesterone deficiency, the reduced placental PIBF1 gene mRNA expression could lead to the breakdown of maternal adaptive reactions aimed at maintaining pregnancy and will be one of the factors that initiate preterm labor.

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About the authors

Yulia E. Dobrokhotova

N.I. Pirogov Russian National Research Medical University

Email: pr.dobrohotova@mail.ru
MD, Head of the Department of Obstetrics and Gynecology of the Medical Faculty

Dmitry Y. Trofimov

Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: d.troflmov@dna-tech.ru
Doctor of Biological Sciences, Head of the Laboratory of Molecular Genetic Methods

Alexander I. Shchegolev

Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: ashegolev@oparina4.ru
MD, Professor, Head of the 2nd Pathoanatomical Department

Olga V. Burmenskaya

Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: o_bourmenskaya@oparina4.ru
Doctor of Biological Sciences, Researcher of the Laboratory of Molecular Genetic Methods

Yulia S. Veselovskaya

N.I. Pirogov Russian National Research Medical University

Email: isveselovskaia@gmail.com
post-graduate student of the Department of Obstetrics and Gynecology of the Faculty of Medicine

Yulia V. Mitrofanova

N.I. Pirogov Russian National Research Medical University

post-graduate student of the Department of Obstetrics and Gynecology of the Medical Faculty

Anton S. Olenev

City Clinical Hospital No. 24

Email: felidis@mail.ru
Candidate of Medical Science, Deputy chief doctor of the City Clinical Hospital No. 24, the head of the Perinatal Center branch.

Andrei Y. Pastarnak

City Clinical Hospital No. 13 branch No. 1 of the Health Department

chief physician

Tamerlan Kazbekovich Gogichaev

City Clinical Hospital No. 29, Branch No. 2, N.E. Bauman Moscow Department of Health

Chief Physician

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