Metabolites of the normal vaginal microflora increase the activity of antibiotics


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Abstract

Objective. Investigation of the influence of metabolites from the lactobacilli isolated from healthy women and LCR35probiotic strain on sensitivity to antibiotics. Subject and methods. We studied the effects of H2O2, lactate, and surfactants obtained from 24 vaginal Lactobacillus spp. and metabolites from L CR35 on sensitivity to antibiotics of 172 strains of opportunistic bacteria. Results. H2O2 and surfactants but no lactic acid were more effective for increasing the sensitivity of bacteria to antibiotics. Strain LCR35 increased sensitivity to antibiotics of all test strains, to a greater extent - G. vaginalis, E. coli and Klebsiella spp. Conclusion. The phenomenon of potentiation of activity of antibiotic by metabolites from vaginal lactobacilli and LCR35 probiotic strain was detected. For effective treatment of inflammatory diseases by antibiotics should take into account the status of the normal microflora, and if necessary, compensate deficit by probiotic strains able to produce “assistants antibiotics”.

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About the authors

Andrey Viktorovich Sgibnev

Institute of Cellular and Intracellular Symbiosis, Ural Branch of RAS

Email: andrej-sgibnev@yandex.ru
doctor of biology, associate professor, leading researcher, Laboratory for the study of the mechanisms of formation microbiocenoses of humans

Elena Aleksandrovna Kremleva

Institute of Cellular and Intracellular Symbiosis, Ural Branch of RAS; Orenburg State Medical University

Email: kremlena1@mail.ru
MD, leading researcher, Laboratory for the study of the mechanisms of formation microbiocenoses of humans; Associate Professor, Department of Obstetrics and Gynecology

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