Proinflammatory factors of mitochondrial origin in the pathogenesis of recurrent miscarriages and early preterm births


如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅或者付费存取

详细

Objective. To carry out a systematic analysis of the data available in the current literature on the influence of proinflammatory factors of mitochondrial origin (mtDAMPs) in the early stages of gestation. Material and methods. The paper analyzes the literature data in the past 10years, by using the search database PubMed. Results. The review outlines the presented results of studies, which suggest that there are variants of interaction of proinflammatory factors of mitochondrial origin (mtDAMPs) in the pathogenesis of recurrent miscarriage and early preterm labor. It provides evidence for an excessive inflammatory response that prevents normal trophoblast invasion and pregnancy complications Conclusion. There is a need for further investigations to set up a system for assessing the individual risk of pregnancy losses and for evaluating the effectiveness of treatment, by selecting the most informative inflammatory markers of mitochondrial origin.

全文:

受限制的访问

作者简介

Yulia Bulatova

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: yu.bulatova@mail.ru
Graduate student, Department of Pregnancy Loss Prevention and Therapy

Nana Tetruashvili

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: tetrauly@mail.ru
Doctor of Medicine, Head of the Department of Pregnancy Loss Prevention and Therapy

Mikhail Vysokikh

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: m_vysokikh@oparina4.ru
PhD, the head of mitochondrial medicine research group

参考

  1. Сидельникова В.М., Сухих Г.Т. Невынашивание беременности. М.: МИА; 2010. 536с. [Sidelnikova V.M., Sukhikh G.T. Unintention of pregnancy. Moscow: MIA; 2010. 536p. (in Russian)]
  2. Краснопольский В.И., Серова О.Ф., Титченко Л.И., Петрухин В.А., Туманова В.А., Зароченцева Н.В., Капустина М.В., Мельник Т.Н., Липовенко Л.Н., Бакотина И.В., Марченко С.Ю., Тамазян Г.В., Гридчик А.Л. Ведение беременности у женщин с невынашиванием в анамнезе. Пособие для врачей. М.; 2007. 24с. [Krasnopolskiy V.I., Serova O.F., Titchenko L.I., Petruhin V.A., Tumanova V.A., Zarochentseva N.V., Kapustina M.V., Melnik T.N., Lipovenko L.N., Bakotina I.V., Marchenko S.Yu., Tamazyan G.V., Gridchik A.L. Conducting pregnancy in women with a history of miscarriage. A manual for doctors. Moscow; 2007. 24p. (in Russian)]
  3. Зайнулина М.С., Корнюшина Е.А., Бикмуллина Д.Р. Тромбофилия: этиологический фактор или патогенетический аспект осложненного течения беременности? Журнал акушерства и женских болезней. 2010; 59(1): 18-30. [Zaynulina M.S., Kornyushina E.A., Bikmullina D.R. Thrombophilia: the etiological factor or pathogenetic aspect of the complicated course of pregnancy? Zhurnal akusherstva i zhenskih bolezney. 2010; 59(1): 18-30. (in Russian)]
  4. Ходжаева З.С., Сухих Г.Т., Мусиенко Е.В. Особенности секреции про- и антиангиогенных факторов в I триместре беременности у женщин с привычным выкидышем в анамнезе. Проблемы репродукции. 2011; 2: 30-4. [Khodzhaeva Z.S., Suhih G.T., Musienko E.V. Features of the secretion of pro-and anti-angiogenic factors in the first trimester of pregnancy in women with a habitual miscarriage in the anamnesis. Problemy reproduktsii. 2011; 2: 30-4. (in Russian)]
  5. Тетруашвили Н.К., Федорова Н.И., Файзуллин Л.З., Карнаухов В.Н. Свободная эмбриональная ДНК в плазме крови как предиктор самопроизвольных потерь беременности у женщин с привычным выкидышем. Акушерство и гинекология. 2012; 6: 4-8. [Tetruashvili N.K., Fedorova N.I., Faizullin L.Z., Karnaukhov V.N. Determination of free embryonic DNA in the plasma of pregnant women for noninvasive prenatal genetic diagnosis. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2012; (6): 4-8. (in Russian)]
  6. Mayhew T.M. Fetoplacental angiogenesis during gestation is biphasic, longitudinal and occurs by proliferation and remodeling of vascular endothelial cells. Placenta. 2002; 23(10): 742-50.
  7. Серова О.Ф., Тамазян Г.В., Соваев Н.И., Трифонова И.А., Елисеев Э.Н. Клиническое значение морфофункционального состояния эндометрия при нарушениях репродуктивной функции. Вопросы гинекологии, акушерства и перинатологии. 2010; 9(4): 43-8. [Serova O.F., Tamazyan G.V., Sovaev N.I., Trifonova I.A., Eliseev E.N. Clinical significance of the morphofunctional state of the endometrium in the violation of reproductive function. Voprosyi ginekologii, akusherstva i perinatologii. 2010; 9(4): 43-8. (in Russian)]
  8. Wenceslau C.F., McCarthy C.G., Szasz T., Spitler K., Goulopoulou S., Webb R.C.; Working Group on DAMPs in Cardiovascular Disease. Mitochondrial damage-associated molecular patterns and vascular function. Eur. Heart J. 2014; 35(18): 1172-7.
  9. Курчакова Т.А., Тютюнник В.Л., Кан Н.Е., Меджидова М.К., Сироткина Е.А. Про- и антиоксидантная система при преждевременных родах. Акушерство и гинекология. 2016; 5: 20-4. http://dx.doi. org/10.18565/aig.2016.5.20-24
  10. Сидельникова В.М. Инфекция как фактор риска невынашивания беременности. Гинекология. 2008; 5: 28-30. [Sidelnikova V.M. Infection as a risk factor for miscarriage. Ginekologiya. 2008; 5: 28-30. (in Russian)]
  11. Малышкина А.И., Можаева А.И., Воронин Д.Н. Особенности реакций врожденного иммунитета у женщин с угрозой прерывания беременности на ранних сроках. Российский иммунологический журнал. 2010; 4: 407-8. [Malyishkina A.I., Mozhaeva A.I., Voronin D.N. Features of the reactions of innate immunity in women with the threat of termination of pregnancy in the early stages. Rossiyskiy immunologicheskiy zhurnal. 2010; 4: 407-8. (in Russian)]
  12. Raj Rai. Should Immunotherapy be used? No. In: Howard J. A. Carp, ed. Reccurent pregnancy loss. 2nd ed. CRC Press; 2015: 265.
  13. Zhang Q., Raoof M., Chen Y., Sumi Y., Sursal T., Junger W. et al. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature. 2010; 464(7285): 104-7.
  14. Romero R., Miranda J., Chaiworapongsa T., Korzeniewski S.J., Chaemsaithong P., Gotsch F. et al. Prevalence and clinical significance of sterile intra-amniotic inflammation in patients with preterm labor and intact membranes. Am. J. Reprod. Immunol. 2014; 72(5): 458-74. doi: 10.1111/aji.12296.
  15. Kataoka H., Kono H., Patel Z., Kimura Y., Rock K.L. Evaluation of the contribution of multiple DAMPs and DAMP receptors in cell death-induced sterile inflammatory responses. PLoS One. 2014; 9(8): e104741. doi: 10.1371/ journal.pone.010474.
  16. Charnock-Jones D.S., Kaufmann P., Mayhew T.M. Aspects of human fetoplacental vasculogenesis and angiogenesis. I. Molecular regulation. Placenta. 2004; 25(2-3): 103-13.
  17. Krysko D.V., Agostinis P., Krysko O., Garg A.D., Bachert C., Lambrecht B.N., Vandenabeele P. Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation. Trends Immunol. 2011; 32: 157-64.
  18. Ni Choileain N., Redmond H.P. The immunological consequences of injury. Surgeon. 2006; 4(1): 23-31.
  19. Lenz A., Franklin G.A., Cheadle W.G. Systemic inflammation after trauma. Injury. 2007; 38(12): 1336-45.
  20. Simmons E.M., Himmelfarb J., Sezer M.T., Chertow G.M., Mehta R.L., Paganini E.P. et al. Plasma cytokine levels predict mortality in patients with acute renal failure. Kidney Int. 2004; 65(4): 1357-65.
  21. Rzepka R., Dofygowska B., Rajewska A., Kwiatkowski S. On the significance of new biochemical markers for the diagnosis of premature labour. Mediators Inflamm. 2014; 2014: 251451. doi: 10.1155/2014/251451.
  22. Yao X., Wigginton J.G., Maass D.L., Ma L. Estrogen-provided cardiac protection following burn trauma is mediated through a reduction in mitochondria-derived DAMPs. Am. J. Physiol. Heart Circ. Physiol. 2014; 306(6): H882-94. doi: 10.1152/ajpheart.00475.2013.
  23. Menon R. Human fetal membranes at term: Dead tissue or signalers of parturition? Placenta. 2016; 44: 1-5. doi: 10.1016/j.placenta.2016.05.013.
  24. Burnstock G. Blood cells: an historical account of the roles of purinergic signaling. Purinergic Signal. 2015; 11(4): 411-34. doi: 10.1007/s11302-015-9462-7.
  25. Spaans F., de Vos P., Bakker W.W., van Goor H., Faas M.M. Danger signals from ATP and adenosine in pregnancy and preeclampsia. Hypertension. 2014; 63(6): 1154-60. doi: 10.1161/HYPERTENSIONAHA.114.03240.
  26. Kohli S., Ranjan S., Hoffmann J., Kashif M., Daniel E.A., Al-Dabet M.M. et al. Maternal extracellular vesicles and platelets promote preeclampsia via inflammasome activation in trophoblasts. Blood. 2016; 128(17): 2153-64.
  27. Salomon C., Yee S., Scholz-Romero K., Kobayashi M., Vaswani K., Kvaskoff D. et al. Extravillous trophoblast cells-derived exosomes promote vascular smooth muscle cell migration. Front. Pharmacol. 2014; 5: 175. doi: 10.3389/ fphar.2014.00175. Collection 2014.

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © ООО «Бионика Медиа», 2017
##common.cookie##