The results of the second wave of investigation of the profile of patients with hormone-dependent conditions and magnesium deficiency


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Abstract

Objective. To assess the profile of female outpatients with various hormone-dependent conditions (HDCs) and magnesium deficiency (MD); to evaluate the clinical efficacy of magnesium citrate + pyridoxine hydrochloride (Magne B6 forte) in routine practice. Subjects and methods. This was a multicenter observational study assessing the profile of 18-60-year-old female outpatients (n = 11,424) with HDCs (MD was estimated using the plasma Mg levels (bone mineral density (BMD) < 0.8 mmol/l and/or the Mood Disorder Questionnaire (MDQ). The clinical efficacy of Magne Bforte (BMD, the severity of symptoms, quality of life), safety profile, and therapy adherence was evaluated in women who used the drug (n = 2,142). Results. The prevalence of MD ranged from 47.7% of the women receiving hormonal contraception to 66.4% of those with osteoporosis. After a month of taking Magne B6 forte, there was an increase in BMD, a reduction in the symptoms potentially related to MD, and an improvement in quality of life. No adverse events were recorded. Conclusion. The prevalence of MD was shown to be high in women with HDCs. Magne B6 forte was effective in compensating for MD; there was a high therapy adherence and a favorable safety profile.

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About the authors

A. D Makatsaria

I.M. Sechenov First Moscow State Medical University

Email: gemostasis@mail.ru
MD, PhD Professor, Correspondent Member of the Russian Academy of Sciences, Head of the Department of Obstetrics and Gynecology of Medical Prophylaxis Facult, Vice-President of Russian Association of Obstetricians and Gynaecologists

Christian Dadak

University Clinic of Obstetrics and Gynecology in Vienna

Email: christian.dadak@meduniwien.ac.at
professor at the University Clinic of Obstetrics and Gynecology in Vienna; Head of the International Center for Postgraduate Education in Women’s Health.

Viktoriya O. Bitsadze

I.M. Sechenov First Moscow State Medical University

Email: vikabits@mail.ru
MD, PhD, Professor of the Department of Obstetrics and Gynecology of Medical Prophylaxis Faculty

Alina Evgen’evna Solopova

I.M. Sechenov First Moscow State Medical University

Email: dr.solopova@mail.ru
Candidate of Medicine, assistant professor, Department of radiology and radiotherapy

Nadin Moktarovna Khamani

I.M. Sechenov First Moscow State Medical University

Email: gemostasis@mail.ru
Post-graduate student of the Department of Obstetrics and Gynecology of the Medical-Prophylactic Faculty

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