Benzodiazepines in the treatment of premenstrual and menopausal syndromes


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Objective. To provide an update-based assessment of the relationship between genetic disorders of the receptor system and somatic and autonomic dysfunctions developing in the framework of premenstrual syndrome and premenstrual dysphoric disorder. The results of new trials of the efficacy of tofisopam (grandaxin) were also analyzed. Material and methods. Publications available in the international science citation databases were sought and analyzed. Results. Tofisopam (grandaxin) is an anxiolytic drug but without muscle relaxant effects; and it can therefore be used in patients who continue to perform their professional duties. Tofisopam has the greatest autonomic stabilizing effect. Tofisopam has been shown to be particularly effective against autonomic disorders accompanying anxiety. Conclusion. Tofisopam remains one of the best drugs in the safety and efficacy ratio today.

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作者简介

Alexander Tikhomirov

A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Email: pacificoff@mail.ru
Doctor of Medical Sciences, Professor of the Department of Obstetrics and Gynecology, Faculty of General Medicine

Svetlana Sarsania

Federal Center for reproduction „Santa Maria”

doctor

Kazbek Tuskaev

Federal Center for reproduction „Santa Maria”

doctor

Viktor Kazenashev

A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Candidate of Medical Sciences, Assistant of the Department of Obstetrics and Gynecology, Faculty of General Medicine

Igor Manukhin

A.I. Yevdokimov Moscow State University of Medicine and Dentistry

MD, Professor, Head of the Department of Obstetrics and Gynecology, Faculty of General Medicine

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