Medicament therapy in the treatment of combined uterine diseases


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Abstract

Objective. Conduct a systematic analysis of the data available in the modern literature, with the purpose of assessing the effectiveness of drug treatment in patients with combined proliferative diseases of the uterus. Material and methods. The review includes data from domestic and foreign articles included in the PUBMED and RINC databases published over the past 10 years. Results. The high prevalence of combined diseases of the uterus (leiomyomas, adenomyosis and endometrial hyperplasia) is described, including among women of working age. The treatment of these patients covers a wide range of conservative and surgical methods. The main goals of medical treatment of combined diseases of the uterus are: improving the quality of life, easing pain and bleeding, the possibility of avoiding a surgical operation and solving the problem of procreation. In order to optimize the correlation between the profiles of efficacy, safety and tolerability of treatment, it is possible to use the advantages of aHHRH (3-4 months) and dienogest (longterm) with their sequential appointment. Conclusion. The development of an algorithm for the treatment with consecutive courses of drugs of various classes seems promising and requires further study.

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About the authors

Susanna Artashesovna Gasparyan

Stavropol State Medical University

MD, Professor, Department of Obstetrics and Gynecology

Olga Aleksandrovna Safonova

Stavropol State Medical University

post-graduate student of the Department of Obstetrics and Gynecology

Marina Hesovna Nalgieva

Ingush Republican Clinical Hospital

head of the gynecological department

Alesya Alexandrovna Khripunova

Stavropol State Medical University

Ph.D., Associate Professor, Department of Public Health, Public Health Service and Medical Informatics

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