Progesterone and reproductive losses
- Authors: Radzinsky V.E.1, Ordiyants I.M.1, Pobedinskaya O.S.2, Zykov E.V.1
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Affiliations:
- Peoples’ Friendship University of Russia
- I.M. Sechenov First Moscow State Medical University
- Issue: No 8 (2017)
- Pages: 109-114
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/248015
- DOI: https://doi.org/10.18565/aig.2017.8.109-14
- ID: 248015
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Open Access
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Abstract
Objective. To evaluate the efficiency of incorporating the micronized progesterone pragisan into a package of measures to prevent and treat miscarriage during early pregnancy. Subjects and methods. The investigation enrolled 30 women who had received first trimester threatened miscarriage treatment and 32 patients with clinical signs of threatened miscarriage who had refused treatment for various reasons. Threatened miscarriage was diagnosed based on complaints and ultrasound diagnosis (shortening of the cervix and dilation of the internal os). Results. The incorporation of the micronized progesterone pragisan into a package of measures aimed at preserving and prolonging pregnancy showed its high efficacy in patients with threatened miscarriage. Pregnancy could be preserved and prolonged to full term by 29 out of the 30 women with threatened miscarriage in the pragisan group and by only 19 (59.4%) in the group of those who had refused treatment. The timely restoration of vaginal biocenosis was also shown to contribute to the normalization of the course of pregnancy. Conclusion. The pronounced clinical efficacy, convenient dosing, and no adverse reactions of pragisan suggest that the drug may be incotporated into a package of measures to treat threatened miscarriage.
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About the authors
Viktor E. Radzinsky
Peoples’ Friendship University of Russia
Email: radzinsky@mail.ru
MD, professor, head of the Department of Obstetrics and Gynecology with the course of Perinatology
Irina M. Ordiyants
Peoples’ Friendship University of Russia
Email: ordiyantc@mail.ru
MD, Professor of the Department of Obstetrics and Gynecology with a course in perinatology
Olesya S. Pobedinskaya
I.M. Sechenov First Moscow State Medical University
Email: pobedinskaya-o@yandex.ru
Candidate of Medical Science, associate professor of the Department of Obstetrics and Gynecology
Evgeniy V. Zykov
Peoples’ Friendship University of Russia
Email: yevgeny_zykov@hotmaM.com
post-graduate student of the Department of Obstetrics and Gynecology with the course of perinatology
References
- Айрапетов Д.Ю., Ордиянц И.М. Иммуногенетическая причина ранних репродуктивных потерь. Врач. 2011; 1: 39-40. [Ayrapetov D.Yu., Ordiyants I.M. Immunogenetic cause of early reproductive losses. Vrach. 2011; 1: 39-40. (in Russian)]
- Неразвивающаяся беременность. Методические рекомендации МАРС (Междисциплинарной ассоциации специалистов репродуктивной медицины). Авт.-сост. В.Е. Радзинский и др. М.: Редакция журнала StatusPraesens; 2015. 48с. [Non-developing pregnancy. Methodical recommendations of MARS (Interdisciplinary Association of Specialists in Reproductive Medicine). Auth.-comp. V.E. Radzinsky et al. Moscow: The editorial staff of the journal StatusPraesens; 2015. 48p. (in Russian)]
- FIGO Working Group On Best Practice In Maternal-Fetal Medicine; International Federation of Gynecology and Obstetrics. Best practice in maternal-fetal medicine. Int. J. Gynaecol. Obstet. 2015; 128(1): 80-2.
- Wiltbank M.C., Baez G.M., Garcia-Guerra A., Toledo M.Z., Monteiro P.L., Melo L.F. et al. Pivotal periods for pregnancy loss during the first trimester of gestation in lactating dairy cows. Theriogenology. 2016; 86(1): 239-53.
- Радзинский В.Е., Жан-Карло-Рензо. Профилактика невынашивания и преждевременных родов в современном мире. Резолюция Экспертного совета в рамках 16-го Всемирного конгресса по вопросам репродукции человека (Берлин, 18-21 марта 2015 года). Информационное письмо. М.: Редакция журнала StatusPraesens; 2015. 4с. [Radzinsky V.E., Jean-Carlo-Renzo. Prevention of miscarriage and premature birth in the modern world. Resolution of the Expert Council within the framework of the 16th World Congress on Human Reproduction (Berlin, March 18-21, 2015). Information mail. Moscow: Editorial office of the journal StatusPraesens; 2015. 4p. (in Russian)]
- Радзинский В.Е., Ордиянц И.М., Добрецова Т.А. Хронический эндометрит и фертильность: новые ответы. Терапевтические возможности преодоления хронического воспаления в эндометрии и улучшения фертильности: информационный бюллетень. М.: Редакция журнала StatusPraesens; 2016. 20с. [Radzinsky V.E., Ordiyants I.M., Dobretsova T.A. Chronic endometritis and fertility: new responses. Therapeutic options for overcoming chronic inflammation in the endometrium and improving fertility: a newsletter. Moscow: Editorial office of the journal StatusPraesens; 2016. 20p. (in Russian)]
- Айрапетов Д.Ю., Ордиянц И.М. Эндокринные изменения у женщин с привычным невынашиванием беременности и гомологией антигенов HLA. Врач. 2012; 8: 71-3. [Ayrapetov D.Yu., Ordiyants I.M. Endocrine changes in women with habitual miscarriage and homology of HLA antigens. Vrach. 2012; 8: 71-3. (in Russian)]
- Радзинский В.Е., Ордиянц И.М., Побединская О.С., Минаева А.В. Профилактика перинатальных осложнений у беременных с анемией. Акушерство и гинекология: новости, мнения, обучение. 2015; 3:137-42. [Radzinsky V.E., Ordiyants I.M., Pobedinskaya O.S., Minaeva A.V. Prevention of perinatal complications in pregnant women with anemia. Obstetrics and gynecology: news, opinions, training. 2015; 3: 137-42. (in Russian)]
- Coomarasamy A., Williams H., Truchanowicz E., Seed P.T., Small R., Quenby S. et al. PROMISE: first-trimester progesterone therapy in women with a history of unexplained recurrent miscarriages - a randomised, double-blind, placebocontrolled, international multicentre trial and economic evaluation. Health Technol. Assess. 2016; 20(41): 1-92.
- Мальцева Л.И., Никогосян Д.М. Эффективность микронизированного прогестерона для профилактики невынашивания беременности. Гинекология. 2015; 17(2): 56-9. [Maltseva L.I., Nikogosyan D.M. The effectiveness of micronized progesterone for the prevention of miscarriage. Ginekologiya. 2015; 17 (2): 56-9. (in Russian)]
- Samir H., Karen A., Ashmawy T., Abo-Ahmed M., El-Sayed M., Watanabe G. Monitoring of embryonic and fetal losses in different breeds of goats using realtime B-mode ultrasonography. Theriogenology. 2016; 85(2): 207-15.
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