Oxidative stress indicators in pregnant women, those who are healthy and those who have urogenital infection, in the early stages of gestation


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Objective. To investigate oxidative stress indicators in women with early physiological pregnancy and in those with early pregnancy complicated by urogenital infection. Subjects and methods. Examinations were made in 90 women aged 20-45years, who were divided into 3 groups: 1) 30 healthy non-pregnant women; 2) 30 healthy pregnant women; 3) 30pregnant women with urogenital infection. All the pregnant women were in the first trimester of pregnancy (at 8-10 weeks). The functional activity of whole blood phagocytes was determined by luminol-dependent chemiluminescence. A chemiluminescent method was also used to measure the antioxidant activity of plasma. The plasma content of one of the lipid peroxidation products, malondialdehyde, was determined spectrophotometrically. Results. There was significantly enhanced functional activity of whole blood phagocytes in the healthy pregnant women and in the pregnant women with urogenital infection versus the healthy non-pregnant women, elevated malondialdehyde levels in their plasma, and its decreased antioxidant activity. Conclusion. Comparison of the indicators of oxidative stress in pregnant women, those who are healthy and those who have urogenital infection, and in the healthy non-pregnant women leads to the conclusion that oxidative stress develops just in the f irst trimester of pregnancy. Urogenital infection in pregnant women contributes to an even greater imbalance between the production of prooxidants and the activity of the antioxidant system.

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作者简介

Bayarma Zhambalova

N.I. Pirogov Russian National Research Medical University

Email: ZhambalovaBA@inbox.ru
Ph.D., Department of Medical Biophysics

Inna Nosikova

N.I. Pirogov Russian National Research Medical University

Email: nosikovainna@mail.ru
student

Svetlana Malushenko

N.I. Pirogov Russian National Research Medical University

Email: malusvetlana@yandex.ru
postgraduate

Alexandra Maksina

N.I. Pirogov Russian National Research Medical University

Email: maxinaalexandra@yandex.ru
Doctor of Biological Sciences, Professor, Department of Physics and Mathematics

Lyudmila Gankovskaya

N.I. Pirogov Russian National Research Medical University

Email: lvgan@yandex.ru
Doctor of Medical Sciences, Professor, Department of Immunology

Yuliya Dobrokhotova

N.I. Pirogov Russian National Research Medical University

Email: pr.dobrohotova@mail.ru
Doctor of Medical Sciences, Professor, Department of Obstetrics and Gynecology

Anatoliy Osipov

N.I. Pirogov Russian National Research Medical University

Email: anosipov@yahoo.com
Doctor of Biological Sciences, Professor, Department of Medical Biophysics

Yuriy Teselkin

Department of Medical Biophysics N.I. Pirogov Russian National Research Medical University

Email: teselkin-box@mail.ru
Doctor of Biological Sciences, Professor

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