Role of hypothalamic (trigger) neuropeptides in the genesis of hot flushes. Prospects for new therapeutic approaches to treating vasomotor menopausal symptoms


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Abstract

Objective. To carry out a systematic analysis of the data available in the current literature on the impact of the neuropeptide regulation of the hypothalamic-pituitary-ovarian axis, which in conjunction with estrogen deficiency underlie the development of vasomotor menopausal manifestations. To determine a vector of new pharmacological approaches in the therapy of menopausal disorders, by taking into account the findings of these studies. Material and methods. The review includes the data of Russian and foreign articles published in the past 10 years and found in Medscape and Pubmed on this topic. Results. The paper describes the possible mechanisms for the involvement of hypothalamic neuronal triggers in the pathogenesis of hot flushes, as well as the varying effect of pharmacological agents in reducing the severity of vasomotor symptoms. It presents new pathogenetically sound approaches to therapy for vasomotor symptoms in the treatment of menopausal syndrome. Conclusion. There is a need for further investigations of the effect of novel medications on neuronal vasomotor triggers in the optimal therapy regimens for menopausal disorders.

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About the authors

Svetlana Vladimirovna Yureneva

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: syureneva@gmail.com
MD, Gynecological Endocrinology Department

Zukhra Khuseyevna Ebzieva

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: zu87@list.ru
postgraduate of gynecological endocrinology department

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