Characteristics of the level of soluble form of receptor for glycation end products in very early threatened preterm labor


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Abstract

Objective. To identify the characteristics of the level of a soluble form of receptors for advanced glycation end products (sRAGE) in women with threatened preterm labor (TBL) at 22-27 weeks’ gestation in relation to the outcome of pregnancy and perinatal pathology. Material and methods. Enzyme immunoassay was used to determine the venous serum levels of sRAGE and antibodies to the causative agents of major infections. Results. Reduced sRAGE levels were characteristic of pregnant women with TBL at 22-27 weeks, which culminated in premature birth (BB), as compared with those with uncomplicated pregnancy and TBL that ended in full-term birth. The patients with TRL, who gave birth to babies with perinatal hypoxic lesions (BHL) of the central nervous system (CNS), showed a more pronounced decrease in sRAGE levels. Conclusion. BB in women with TBL at 22-27 weeks was associated with a reduction in sRAGE levels. The low content of sRAGE in those with TBL at 22-27 weeks is a predictor for the development of BHL of the CNS.

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About the authors

Anastasia Vladimirovna Smirnova

Ivanovo State Medical Academy, Ministry of Health of Russia

Email: anguseva@yandex.ru
Ph.D., Assistant of the Department of Obstetrics and Gynecology, Medical Genetics

Nadezhda Yurievna Borzova

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia

Email: borzova_n@mail.ru
MD, professor, chief research officer of the Department of Obstetrics and Gynecology

Natalia Yurievna Sotnikova

Ivanovo State Medical Academy, Ministry of Health of Russia; V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia

Email: niimid.immune@mail.ru
MD, professor, head of the Laboratory of Clinical Immunology; professor of the Department of Pathophysiology, Clinical Pathophysiology and Immunology

Anna Ivanovna Malyshkina

Ivanovo State Medical Academy, Ministry of Health of Russia; V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia

MD, director; Head of the Department of Obstetrics and Gynecolog

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