Effect of metformin on the reproductive function of women with different phenotypes of polycystic ovary syndrome


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Objective. To evaluate the efficacy of metformin in the androgen and non-androgen phenotypes of polycystic ovary syndrome (PCOS). Subject and methods. The investigation included 143 women (mean age, 26.4±4.6years; mean body mass index, 23.8±4.8 kg/m2) with PCOS. A comprehensive examination, Including a pelvic ultrasound, was made; serum androgens, anti-Müllerian hormone (AMH), luteinizing hormone (LH), and follicle-stimulating hormone levels were determined; and two-hour glucose tolerance test was carried out to estimate the levels of glucose and insulin at baseline and after 6 months of therapy. The patients were divided into two groups: 1) 101 women with the androgen phenotypes of PCOS; 2) 42 women with its non-androgen phenotype. All the patients were treated with metformin 1500 mg/day for 6 months. Results. The mean levels of AMH and LH were higher in the androgen phenotype group (p < 0.05). There were no differences in the frequency of metabolic disorders; the mean level of fasting insulin was higher in women with hyperandrogenism. After 6 months of metformin therapy, there were decreases in the level of LH, androgens, and insulin in Group 1 (p < 0.05) and in that of AMH in both groups. Regardless of the phenotype of PCOS, the menstrual cycle was regulated in every two patients; pregnancy occurred in every three patients. Conclusion. Therapy with metformin at a dose of 1500 mg daily can be considered as an effective approach to correcting ovulatory dysfunction irrespective of the phenotype of the syndrome.

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作者简介

A. Naidukova

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: aleeshka@mail.ru
post-graduate student, Department of Gynecological Endocrinology

E. Ananyev

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: new_vision@mail.ru
head of the 2nd maternity ward

G. Chernukha

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: c-galina1@yandex.ru
head of the Department of Gynecological Endocrinology

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