Prevention of hemolytic disease of the fetus and newborn by anti-D-immunoprophylaxis
- Authors: Pavlova N.G.1,2,3
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Affiliations:
- I.P. Pavlov First St. Petersburg State Medical University
- St. Petersburg State University
- Maternity Hospital No. 6 in St. Petersburg
- Issue: No 9 (2017)
- Pages: 138-143
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/248060
- DOI: https://doi.org/10.18565/aig.2017.9.138-43
- ID: 248060
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Abstract
Objective. To analyze the data available in the current literature regarding the prevention of hemolytic disease of the fetus and newborn by anti-D immunoprophylaxis. Material and methods. The review included the data of foreign and Russian articles published in the past 10years and found in PubMed on this topic. Results. The review presents the epidemiology and pathogenesis of sensitization in Rh-negative pregnant women having an Rh-positive fetus, the need for immunoprophylaxis of hemolytic disease of the fetus and newborn, indications, regimens, and the required volumes of immunoprophylaxis in different obstetric situations, and the choice of an immunoglobulin. Conclusion. Understanding the pathogenetic bases for the immunoprophylaxis of D-sensitization, as well as steady execution of clinical guidelines for the management of patients having pregnancy in rhesus-incompatibility marriage will assist in improving perinatal indicators and reproductive health in women.
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About the authors
Natalia Grigorievna Pavlova
I.P. Pavlov First St. Petersburg State Medical University; St. Petersburg State University; Maternity Hospital No. 6 in St. Petersburg
Email: ngp05@yandex.ru
MD, Professor of the Department of Obstetrics, Gynecology and Reproduction; Professor of the Department of Obstetrics, Gynecology and Reproduction; Deputy Chief Physician for Perinatology of Maternity Hospital No. 6 in St. Petersburg
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