Optimization of endometrial preparation prior to assisted reproductive technology programs for HIV-infected women with tuboperitoneal factor infertility


Citar

Texto integral

Acesso aberto Acesso aberto
Acesso é fechado Acesso está concedido
Acesso é fechado Acesso é pago ou somente para assinantes

Resumo

Objective. To assess the possibility of enhancing the efficiency of assisted reproductive technologies (ART) in HIV-infected patients with infertility after therapeutic and diagnostic hysteroscopy (TDH). Subjects and methods. A prospective study was conducted in 121 HIV-infected women with infertility in preparation for ART. Of them, 63 patients underwent TDH (a study group) and 58patients did not (a control group); randomization was performed by an envelope method. The investigation methods included histology and ultrasonography (USG). Results. Endometrial pathology was detected in 79.5% of the study group and in 51 % of the control group where only USG was carried out (p < 0.05). After TDH conducted before IVF, the pregnancy rate was higher (40.7 versus 14.2%; p < 0.05); the frequency of miscarriage with a small duration of gestation was lower (14.8 versus 50%; p < 0.05). Conclusion. TDH in HIV-infected patients with infertility enhances the efficiency of IVF and reduces the risk of miscarriage.

Texto integral

Acesso é fechado

Sobre autores

Valentina Medvedeva

Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia; Family Medicine Center, Yekaterinburg

Email: Medvedeva-V-V@mail.ru
MD, aspirant

Galina Malygina

Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia

Email: galinamalgina@mail.ru
doctor of medical Sciences

Bibliografia

  1. Министерство здравоохранения Российской Федерации. Материалы по деятельности Департамента от 19.12.16. Available at: https://www.ros-minzdrav.ru/ministry/61/5/1
  2. Божедомов В.А. Мужской фактор бездетного брака - пути решения проблемы. Урология. 2016; Приложение 1: 28-34. doi: 10.1111 /j.2047- 2927.2013.00160.x.
  3. Sauer M. American physicians remains low to embrace the reproductive needs of human immunodeficiency virus-infected patients. Fertil. Steril. 2010; 85(2): 295-7. doi: 10.1016/j.fertnstert.2005.08.019.
  4. Robertson M., Wei S.C., Beer L., Adedinsewo D., Stockwell S., Dombrowski J.C. et al. Delayed entry into HIV medical care in a nationally representative sample of HIV-infected adults receiving medical care in the USA. AIDS Care. 2016; 28(3): 325-33. doi: 10.1080/09540121.2015.1096891.
  5. Cejtin H.E. Gynecologic issues in the HIV-infected woman. Infect. Dis. Clin. North Am. 2012; 22(4): 709-39. doi: 10.1016/j.idc.2008.05.006.
  6. Kaushic C. HIV-1 infection in the female reproductive tract: role of interactions between HIV-1 and genital epithelial cells. Am. J. Reprod. Immunol. 2011; 65(3): 253-60. doi: 10.1111/j.1600-0897.2010.00965.x.
  7. Carias A.M., Mc Coombe S., Mc Raven M., Anderson M., Galloway N., Vandergrift N. et al. Defining the interaction of HIV-1 with the mucosal barriers of the female reproductive tract. J. Virol. 2013; 87(21): 11388-400. doi: 10.1128/ JVI.01377-13.
  8. Kedem E., Shahar E., Hassoun G., Pollack S. Fertility and HIV: equal opportunity for everyone. Harefuah. 2013; 152(4): 235-7, 245. doi: 10.2174/157016208785861212.
  9. Gosselin J.T., Sauer M.V. Life after HIV: examination of HIV serodiscordant couples’ desire to conceive through assisted reproduction. AIDS Behav. 2011; 15(2): 469-78. doi: 10.1007/s10461-010-9830-9.
  10. Ohl J., Partisani M., Demangeat C., Binder-Foucard F., Nisand I., Lang J.M. Alterations of ovarian reserve tests in Human Immunodeficiency Virus (HIV)-infected women. Gynecol. Obstet. Fertil. 2010; 38(5): 313-7. doi: 10.1016/j. gyobfe.2010.07.019.
  11. Yalamanchi S., Dobs A., Greenblatt R.M. Gonadal function and reproductive health in women with human immunodeficiency virus infection. Endocrinol. Metab. Clin. North Am. 2014; 43(3): 731-41.
  12. Гафуров Ю.Т., Краснопольский В.И., Назаренко Т.А., Сундуков А.В. Гинекологические заболевания у ВИЧ-инфицированных больных. Клинико-лабораторные особенности, принципы диагностики и лечения. Российский вестник акушера-гинеколога. 2012; 12(2): 65-8.
  13. Melo M.A., Meseguer M., Bellver J., Remohi J., Pellicer A., Garrido N. Human immunodeficiency type-1 virus (HIV-1) infection in serodis-cordant couples (SDCs) does not have an impact on embryo quality or intracytoplasmic sperm injection (ICSI) outcome. Fertil. Steril. 2010; 89(1): 141-50.
  14. Stora C., Epelboin S., Devouche E., Matheron S., Epelboin L., Yazbeck C. et al. Women infected with human immunodeficiency virus type 1 have poorer assisted reproductionoutcomes: a case-control study. Fertil. Steril. 2016; 105(5): 1193-201. doi: 10.1016/j.fertnstert.2015.12.138.
  15. Mugo N.R., Kiehlbauch J., Kiviat N., Nguti R., Gichuhi J.W., Stamm W.E., Cohen C.R. Endometrial histopathology in patients with laparoscopic proven salpingitis and HIV-1 infection. Infect. Dis. Obstet. Gynecol. 2011; 2011: 407057.
  16. Lisovskaya T.V., Malgina G.B., Perepletina T.A., Medvedeva V.V., Kireev D.E., Shipulin G.A., Pungina M.Yu. Pathology of the endometrium in women with chronic hepatitis C. and HIV infection as a cause of unsuccessful in vitro fertilization attempts. Gynecol. Endocrinol. 2015; 31(Suppl. 1): 18-21. doi: 10.3109/09513590.2015.1085195
  17. ВИЧ. СПИД. ВИЧ-инфекция. Available at: http://www.doctoribolit.ru/?go= Derma/Derma_012_Aids_1
  18. Амян Т.С., Перминова С.Г., Кречетова Л.В., Вторушина В.В., Митюрина Е.В. Иммунологические аспекты повторных неудач имплантации в программе экстракорпорального оплодотворения. Акушерство и гинекология. 2017; 1: 5-12. doi: 10.18565/aig.2017.1.5-12.

Arquivos suplementares

Arquivos suplementares
Ação
1. JATS XML
Baixar

Declaração de direitos autorais © Bionika Media, 2018