Optimization of endometrial preparation prior to assisted reproductive technology programs for HIV-infected women with tuboperitoneal factor infertility


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Objective. To assess the possibility of enhancing the efficiency of assisted reproductive technologies (ART) in HIV-infected patients with infertility after therapeutic and diagnostic hysteroscopy (TDH). Subjects and methods. A prospective study was conducted in 121 HIV-infected women with infertility in preparation for ART. Of them, 63 patients underwent TDH (a study group) and 58patients did not (a control group); randomization was performed by an envelope method. The investigation methods included histology and ultrasonography (USG). Results. Endometrial pathology was detected in 79.5% of the study group and in 51 % of the control group where only USG was carried out (p < 0.05). After TDH conducted before IVF, the pregnancy rate was higher (40.7 versus 14.2%; p < 0.05); the frequency of miscarriage with a small duration of gestation was lower (14.8 versus 50%; p < 0.05). Conclusion. TDH in HIV-infected patients with infertility enhances the efficiency of IVF and reduces the risk of miscarriage.

Full Text

Restricted Access

About the authors

Valentina Vladimirovna Medvedeva

Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia; Family Medicine Center, Yekaterinburg

Email: Medvedeva-V-V@mail.ru
MD, aspirant

Galina Borisovna Malygina

Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia

Email: galinamalgina@mail.ru
doctor of medical Sciences

References

  1. Министерство здравоохранения Российской Федерации. Материалы по деятельности Департамента от 19.12.16. Available at: https://www.ros-minzdrav.ru/ministry/61/5/1
  2. Божедомов В.А. Мужской фактор бездетного брака - пути решения проблемы. Урология. 2016; Приложение 1: 28-34. doi: 10.1111 /j.2047- 2927.2013.00160.x.
  3. Sauer M. American physicians remains low to embrace the reproductive needs of human immunodeficiency virus-infected patients. Fertil. Steril. 2010; 85(2): 295-7. doi: 10.1016/j.fertnstert.2005.08.019.
  4. Robertson M., Wei S.C., Beer L., Adedinsewo D., Stockwell S., Dombrowski J.C. et al. Delayed entry into HIV medical care in a nationally representative sample of HIV-infected adults receiving medical care in the USA. AIDS Care. 2016; 28(3): 325-33. doi: 10.1080/09540121.2015.1096891.
  5. Cejtin H.E. Gynecologic issues in the HIV-infected woman. Infect. Dis. Clin. North Am. 2012; 22(4): 709-39. doi: 10.1016/j.idc.2008.05.006.
  6. Kaushic C. HIV-1 infection in the female reproductive tract: role of interactions between HIV-1 and genital epithelial cells. Am. J. Reprod. Immunol. 2011; 65(3): 253-60. doi: 10.1111/j.1600-0897.2010.00965.x.
  7. Carias A.M., Mc Coombe S., Mc Raven M., Anderson M., Galloway N., Vandergrift N. et al. Defining the interaction of HIV-1 with the mucosal barriers of the female reproductive tract. J. Virol. 2013; 87(21): 11388-400. doi: 10.1128/ JVI.01377-13.
  8. Kedem E., Shahar E., Hassoun G., Pollack S. Fertility and HIV: equal opportunity for everyone. Harefuah. 2013; 152(4): 235-7, 245. doi: 10.2174/157016208785861212.
  9. Gosselin J.T., Sauer M.V. Life after HIV: examination of HIV serodiscordant couples’ desire to conceive through assisted reproduction. AIDS Behav. 2011; 15(2): 469-78. doi: 10.1007/s10461-010-9830-9.
  10. Ohl J., Partisani M., Demangeat C., Binder-Foucard F., Nisand I., Lang J.M. Alterations of ovarian reserve tests in Human Immunodeficiency Virus (HIV)-infected women. Gynecol. Obstet. Fertil. 2010; 38(5): 313-7. doi: 10.1016/j. gyobfe.2010.07.019.
  11. Yalamanchi S., Dobs A., Greenblatt R.M. Gonadal function and reproductive health in women with human immunodeficiency virus infection. Endocrinol. Metab. Clin. North Am. 2014; 43(3): 731-41.
  12. Гафуров Ю.Т., Краснопольский В.И., Назаренко Т.А., Сундуков А.В. Гинекологические заболевания у ВИЧ-инфицированных больных. Клинико-лабораторные особенности, принципы диагностики и лечения. Российский вестник акушера-гинеколога. 2012; 12(2): 65-8.
  13. Melo M.A., Meseguer M., Bellver J., Remohi J., Pellicer A., Garrido N. Human immunodeficiency type-1 virus (HIV-1) infection in serodis-cordant couples (SDCs) does not have an impact on embryo quality or intracytoplasmic sperm injection (ICSI) outcome. Fertil. Steril. 2010; 89(1): 141-50.
  14. Stora C., Epelboin S., Devouche E., Matheron S., Epelboin L., Yazbeck C. et al. Women infected with human immunodeficiency virus type 1 have poorer assisted reproductionoutcomes: a case-control study. Fertil. Steril. 2016; 105(5): 1193-201. doi: 10.1016/j.fertnstert.2015.12.138.
  15. Mugo N.R., Kiehlbauch J., Kiviat N., Nguti R., Gichuhi J.W., Stamm W.E., Cohen C.R. Endometrial histopathology in patients with laparoscopic proven salpingitis and HIV-1 infection. Infect. Dis. Obstet. Gynecol. 2011; 2011: 407057.
  16. Lisovskaya T.V., Malgina G.B., Perepletina T.A., Medvedeva V.V., Kireev D.E., Shipulin G.A., Pungina M.Yu. Pathology of the endometrium in women with chronic hepatitis C. and HIV infection as a cause of unsuccessful in vitro fertilization attempts. Gynecol. Endocrinol. 2015; 31(Suppl. 1): 18-21. doi: 10.3109/09513590.2015.1085195
  17. ВИЧ. СПИД. ВИЧ-инфекция. Available at: http://www.doctoribolit.ru/?go= Derma/Derma_012_Aids_1
  18. Амян Т.С., Перминова С.Г., Кречетова Л.В., Вторушина В.В., Митюрина Е.В. Иммунологические аспекты повторных неудач имплантации в программе экстракорпорального оплодотворения. Акушерство и гинекология. 2017; 1: 5-12. doi: 10.18565/aig.2017.1.5-12.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies