THE PATHOGENESIS AND DIAGNOSIS OF ADENOMYOSIS: CURRENT ASPECTS


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Abstract

Objective. To analyze the data available in modern scientific literature on the pathogenesis of adenomyosis and the newest possibilities of its early diagnosis. Subjects and methods. The review included the data of articles from international peer-reviewed databases. Different points of view on the studied topic were examined. Results. The basic mechanisms responsible for the development of adenomyosis were described. The possibilities of current methods for its early diagnosis were analyzed, by taking into account the main pathogenetic mechanisms. Conclusion. The change in the connecting zone (CZ) thickness and the invasion of the endometrium into the myometrium may represent very early-stage adenomyosis. The possibility for imaging the lateral boundaries of the CZ on the same 3D ultrasound image has greatly expanded the potential of echography in detecting the early changes not only in the outer myometrium, but also in the inner myometrium.

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About the authors

Kistaman M. Dzhamalutdinova

Email: DK0590@mail.ru
postgraduate student of the Department of Operative Gynecology, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4

Irena F. Kozachenko

Ph.D., Senior Researcher of the Department of Operative Gynecology, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia 117997, Russia, Moscow, Ac. Oparina str. 4

Alexander I. Gus

MD, Professor, Head of the Functional Diagnostics Department, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4

Leyla V. Adamyan

Email: Adamyanleila@gmail.com
MD, professor, deputy. director and head of the department of operative gynecology, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4

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