THE CLINICAL AND GENETIC PARALLELS OF VITAMIN D PROVISION AND BENIGN BREAST DISEASES


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Abstract

Objective. To investigate vitamin D (VD) levels in women with various forms of benign breast diseases (BBD) in relation to their clinical features, as well as the impact of CYP2R1 rs2060793polymorphism on the level of VD. Subjects and methods. Genotyping for the locus -1559 T>C gene CYP2R1 (rs2060793) was carried out by realtime polymerase chain reaction in 247 women (131 healthy individuals and 116patients with BBD). The level of VD was estimated by chemiluminescence immunoassay in 100patients with BBD and 75 healthy women. Results. 88% of the patients with BBD had a low blood VD level while 53% of them had VD deficiency that correlated with the severity of the disease. The lowest VD provision among the healthy women is characteristic of homozygous carriers of C alleles in the CYP2R1 gene. The patients with BBD had a persistent VD def icient state, regardless of the variant of CYP2R1 gene polymorphism. Conclusion. VD deficiency in women with BBD has a direct impact on the clinical symptoms of the disease and is unassociated with the genetic polymorphism in the CYP2R1 gene.

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About the authors

Larisa Ivanovna Maltseva

Email: laramalc@mail.ru
Doctor of Medicine, Professor, Head of Department of Obstetrics and Gynecology № 1, Kazan State Medical Academy. 420012, Russia, Kazan, Butlerova str. 36

Yulia Vladimirovna Garifullova

Email: gamil.garifullov@yandex.ru
PhD, Assistant of the Department of Obstetrics and Gynecology № 1, Kazan State Medical University. 420012, Russia, Kazan, Butlerova str. 49

Olga Aleksandrovna Kravtsova

Email: okravz@yandex.ru
PhD, Senior lecturer, Department of Biochemistry and Biotechnology, Institute of Fundamental Medicine and Biology, Kazan Federal University. 420008, Russia, Kazan, Kremlevskaya str. 18

References

  1. Morrow M., Schnitt S.J., Norton L. Current management of lesions associated with an increased risk of breast cancer. Nat. Rev. Clin. Oncol. 2015; 12(4): 227-38.
  2. Socolov D., Anghelache I., Ilea C., Socolov R., Carauleanu A. Benign breast disease and the risk of breast cancer in the next 15 years. Rev. Med. Chir. Soc. Med. Nat. Iasi. 2015; 119(1): 135-40.
  3. Dyrstad S.W., Yan Y., Eowler A.M., Colditz G.A. Breast cancer risk associated with benign breast disease: systematic review and meta-analysis. Breast Cancer Res. Treat. 2015; 149(3): 569-75.
  4. Eliassen A.H., Warner E.T., Rosner B., Collins L.C., Beck A.H., Quintana L.M. et al. Plasma 25 hydroxyvitamin D and risk of breast cancer in women followed over 20 years. Cancer Res. 2016; 76(18): 5423-30.
  5. Rejnmarka L., Tietzeb A., Vestergaarda P., Buhlc L., Lehbrinkb M., Heickendorffd L. et al. Reduced pre-diagnostic 25-hydroxyvitamin D levels in women with breast cancer. Bone. 2009; 44: S162-7.
  6. Brian L., Sprague A., Trentham-Dietz R.E., Gangnon D.S., Buist M. et al. The vitamin D pathway and mammographic breast density among postmenopausal women. Breast Cancer Res. Treat. 2012; 131(1): 255-65.
  7. Zhang Z., He J.W., Eu W.Z., Zhang C.Q., Zhang Z.L. An analysis of the association between the vitamin D pathway and serum 25-hydroxyvitamin D levels in a healthy Chinese population. J. Bone Miner. Res. 2013; 28(8): 1784-92.
  8. Anderson L.N., Cotterchio M., Knight J.A., Borgida A., Gallinger S., Cleary S.P. Genetic variants in vitamin D pathway genes and risk of pancreas cancer; results from a population-based case-control ctudy in Ontario, Canada. PLoS One. 2013; 8(6): e66768. doi: 10.1371/journal.pone.0066768.
  9. Ahn J., Yu K., Stolzenberg-Solomon R., Simon K.C., McCullough M.L., Gallicchio L. et al. Genome-wide association study of circulating vitamin D levels. Hum. Mol. Genet. 2010; 19(13): 2739-2745.
  10. Lopes N., Sousa B., Martins D., Gomes M., Vieira D., Veronese L.A. et al. Alterations in vitamin D signaling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions Vitamin D pathways unbalanced in breast lesions. BMC Cancer. 2010; 10: 483-92.
  11. Jeong Y., Swami S., Krishnan A.V., Williams J.D., Martin S., Horst R.L. et al. Inhibition of mouse breast tumor initiating cells by calcitriol and dietary vitamin D. Mol. Cancer Ther. 2015; 14(8): 1951-61.

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