METASTATIC BRAIN INVOLVEMENT IN GENITAL CANCER


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Abstract

Objective. To analyze a group of patients with brain metastases from genital cancer. Material and methods. From 2002 to 2016, the investigators followed up 26 patients aged 25 to 74 years who had brain metastases from genital cancer. Results. Brain metastases occurred more frequently in patients with ovarian malignancies, then in those with uterine corpus and cervical cancer. The shortest time from primary tumor detection to diagnosis of brain metastases was 1 month in a patient with chorion carcinoma; that averaged 27.5 months in those with ovarian malignancies, 34.2 and 41 months in those with uterine corpus and cervical cancer, respectively. Conclusion. Metastatic brain involvement has clinical features that should be taken into account in the clinical and laboratory diagnosis for the early detection of brain metastases and subsequent treatment.

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About the authors

Galina Andreevna Nerodo

Email: rnioi@list.ru
MD, PhD, Professor, corresponding member of RAS, chief researcher, Rostov Research Institute of Oncology, Ministry of Health of Russia. 344037, Russia, Rostov-on-Don, 14-ya liniya str. 63

Liubov Yurievna Vladimirova

Email: vlu@aaanet.tu
MD, PhD, Professor, Head of Department of Drug Therapy No.1, Rostov Research Institute of Oncology, Ministry of Health of Russia. 344037, Russia, Rostov-on-Don, 14-ya liniya str. 63

Irina Stepanovna Mitashok

Email: imitashok@mail.ru
Head of Department of Drug Therapy No.2, Rostov Research Institute of Oncology, Ministry of Health of Russia. 344037, Russia, Rostov-on-Don, 14-ya liniya str. 63

Elena Aleksandrovna Kalabanova

Email: alenakalabanova@mail.ru
MD, PhD, senior researcher, Rostov Research Institute of Oncology, Ministry of Health of Russia. 344037, Russia, Rostov-on-Don, 14-ya liniya str. 63

Eduard Evgenievich Rostorguev

Email: ed.rost@mail.ru
MD, PhD, Head of Department of Neurooncology, Rostov Research Institute of Oncology, Ministry of Health of Russia. 344037, Russia, Rostov-on-Don, 14-ya liniya str. 63

References

  1. Зайцев А.М., Новикова Е.Г., Кирсанова О.Н., Куржупов М.И., Потапова Е.А. Лечение больных раком яичников с метастазами в головном мозге. Онкология. Журнал им. П.А.Герцена. 2015; 4(4): 64-71. [Zaitsev A.M., Novikova E.G., Kirsanova O.N., Kurzhupov M.I., Potapova E.A. Treatment in patients with ovarian cancer metastasizing to the brain. Onkologiya. Zhurnal im. P.A. Gertsena. 2015; 4(4): 64-71. (in Russian)]
  2. NCCN clinical practice guidelines in oncology. Central Nervous System Cancers. Version I. 2013.
  3. Forster M.D., Dedes K.J., Sandhu S., Frentzas S., Kristeleit R., Ashworth A. et al. Treatment with olaparib in patient with PTEN-deficient endometrioid endometrial cancer. Nat. Rev. Clin. Oncol. 2011; 8(5): 302-6.
  4. Севян Н.В., Карахан В.Б., Цыбульская Ю.А., Бондаренко Ю.В. Церебральные метастазы рака эндометрия. Диагностические и нейрохирургические аспекты. Опухоли женской репродуктивной системы. 2013; 1-2: 72-82. [Sevyan N.V, Karakhan V.B., Tsybulskaya Yu.A., Bondarenko Yu.V. Cerebral metastases of endometrial carcinoma. Diagnostic and neurosurgical aspects. Opukholi zhenskoi reproduktivnoi sistemy. 2013; 1-2: 72-82. (in Russian)]
  5. Неродо Г.А., Владимирова Л.Ю., Калабанова Е.А., Росторгуев Э.Е., Кабанов С.Н. Метастатическое поражение головного мозга при онкогенитальной патологии. Злокачественные опухоли. 2016; 4(Спецвыпуск 1): 306. [Nerodo G.A., Vladimirova L.Yu., Kalabanova E.A, Rostorguev E.E., Kabanov S.N. Brain metastasis in oncogenital pathology. Zlokachestvennye opukholi. 2016; (4, Suppl. 1): 306. (in Russian)]
  6. Насхлеташвили Д.Р., Карахан В.Б., Севян Н.В. Выбор тактики лечения больных раком яичников с метастазами в головной мозг. Опухоли головы и шеи. 2011; 4: 12-4. [Naskhletashvili D.R., Karakhan V.B., Sevyan N.V. Choice of treatment policy for ovarian cancer patients with metastatic brain involvement. Opukholi golovy i shei. 2011; 4: 12-14. (in Russian)]
  7. Kawamura D., Tanaka T., Fuga M., Yanagisawa T., Tochigi S., Irie K. et al. Slow progression of calcified cerebellar metastasis from ovarian cancer: a case report and review of the literature. Neurol. Med. Chir. (Tokyo). 2013; 53(10): 722-6.
  8. Цыганкова Л.В., Рязанцев Е.Л., Бирюков А.Н. Рак бартолиновой железы с метастазом в головной мозг. Российский медико-биологический вестник им. академика И.П.Павлова. 2010; 1: 156-9. [Tsygankova L.V., Ryazantsev E.L., Biryukov A.N. The cancer of bartholin’s gland with metastasis in the brain. Rossiiskii mediko-biologicheskii vestnik im.akademika I.P.Pavlova. 2010; 1: 156-159. (in Russian)]

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