Differentiated approach to choosing therapy for women with abnormal uterine bleeding


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Abstract

Objective. To review published scientific papers in order to analyze an evidence base for a strategy for choosing therapy in women with abnormal uterine bleeding (AMC), obesity, and smoking. Material and methods. Foreign and Russian articles published in the past 7 years and selected in Pubmed were used. Results. The types of AMC were analyzed in relation to its etiological factors. Different methods for treating patients with uterine bleeding varying in severity were comparatively analyzed. Conclusion. It is appropriate to concomitantly use dydrogesterone and tranexamic acid in phase 2 of the menstrual cycle during 3-4 menstrual cycles in women who smoke and/or in those with obesity and AMC.

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About the authors

Alina Viktorovna Solovyeva

Peoples’ Friendship University of Russia

MD Professor of the Department of Obstetrics Gynecology with a course of perinatology

Kristina Stanislavovna Ermolenko

Peoples’ Friendship University of Russia

Candidate of Medical Science, Assistant of the Department of Obstetrics of Gynecology and Perinatology

References

  1. Munro M.G., Critchley H.O., Fraser I.S. The FIGO classification of causes of abnormal uterine bleeding in the reproductive years. Fertil. Steril. 2011; 95(7): 2204-8.
  2. Duckitt K., Collins S. Menorrhagia. BMJ Clin Evid. 2012; 2012: pii: 0805. Available at: www. ncbi. nlm. nih.gov
  3. Радзинский В.Е., ред. Неразвивающаяся беременность. 2-е изд. М.: ГЭОТАР-Медиа; 2016. 176с.
  4. Соловьева А.В., Оленев А.С., Гаче В., Хорольский В.А., Кузнецова О.А. Анемии у женщин репродуктивного возраста. Вопросы гинекологии, акушерства и перинатологии. 2016; 15(4): 59-63.
  5. Singh S., Best C., Dunn S., Leyland N., Woljman W.L.; CLINICAL PRACTICE - GYNAECOLOGY COMMITTEE. Abnormal uterine bleeding in pre-menopausal women. J. Obstet. Gynaecol. Can. 2013; 35(5): 473-5.
  6. Farquhar C., Brown J. Oral contraceptive pill for heavy menstrual bleeding. Cochrane Database Syst. Rev. 2009; (4): CD000154.
  7. Heavy menstrual bleeding: assessment and management. Clinical guideline (CG44). Published date: January 2007. Last updated: August 2016. Available at: https://www.nice.org.uk/guidance/cg44
  8. Trivedi N., Chauhan N., Vaidya V. Effectiveness and safety of dydrogesterone in regularization of menstrual cycle: a post-marketing study. Gynecol. Endocrinol. 2016; 32(8): 667-71.
  9. Васюкова О. В., Конь И.А., Ларионова З. Г., Леонтьева И.В., Павловская Е.В., Порядина Г.И., Розанов В.Б., Стародубова А.В., Щербакова М.Ю. Рекомендации по диагностике, лечению и профилактике ожирения у детей и подростков. Александров А.А., Петеркова В.А., ред. М.: Практика; 2015.
  10. Кузнецова И.В., Успенская Ю.Б., Ведзижева Э.Р., Васильева И.В. Ожирение и женская фертильность. Акушерство и гинекология: новости, мнения, обучение. 2015; 3: 109-17.
  11. Думановская М.Р., Чернуха Г.Е., Асатурова А.В., Коган Е.А. Частота выявления и структура гиперплазии эндометрия в различные возрастные периоды. Акушерство и гинекология. 2015; 3: 40-4.
  12. Санта-Мария Фернандес Д.О., Кузнецова И.В., Гитель Е.П. Комплексная терапия нарушений менструального цикла у пациенток раннего репродуктивного возраста с избыточной массой тела и ожирением. Эффективная фармакотерапия. 2015; 5: 26-32.
  13. Pomp E.R., le Cessie S., Rosendaal F.R., Doggen C.J. Risk of venous thrombosis: obesity and its joint effect with oral contraceptive use and prothrombotic mutations. Br. J. Haematol. 2007; 139(2): 289-96.
  14. Trussell J., Jordan B. Reproductive health risks in persperctive. Contraception. 2006; 73(5): 437-9.
  15. Shindler A.E. Progestational effects of dydrogesterone in vitro, in vivo and on the human endometrium. Maturitas. 2009; 65(Suppl. 1): S3-11.
  16. Carlson M.J., Thiel K.W., Yang S., Leslie KK. Catch it before it kills: progesterone, obesity, and the prevention of endometrial cancer. Discov. Med. 2012; 14(76): 215-22.
  17. Heavy menstrual bleeding: Then and now. Gynaecol. Perinatol. 2018; 1.2: 130-9.

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