Role of stem cell dysfunction in the development of great obstetrical syndromes


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Abstract

The paper provides a systems analysis of data on functional changes in the resident uterine and placental stem cells in preeclampsia (PE) and fetal growth restriction syndrome (FGRS); in particular, it discusses a reduction in their proliferative and angiogenic potential and an increase in the production of proinflammatory factors. It considers different aspects of cell therapy, ranging from the type of stem cells and their sources to the supposed mechanisms of therapeutic action, which determine the positive effect, as applied to therapy for PE and FGRS. The analysis of the data available in the literature could lead to the conclusion that cellular technologies are promising in treating PE and FGRS. Nonetheless, for their successful introduction into clinical practice, it is necessary to conduct further investigations of the comparative characteristics of stem cells in normal and pathological pregnancy, as well as the decoding of their molecular behavior in both cases.

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About the authors

Gennady T. Sukhikh

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia

Email: g_sukhikh@oparina4.ru
PhD, Professor, Academician of RAS, Director

Denis N. Silachev

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia; A.N. Belozersky Institute of Physicochemical Biology, M.V. Lomonosov Moscow State University

Email: silachevdn@genebee.msu.ru
PhD. Senior Research Scientist

Kirill V. Goryunov

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia

Email: k_gorunov@oparina4.ru
Junior Research Scientist, laboratory of cell technologies

Maria V. Volochaeva

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia

Email: m_volochaeva@oparina4.ru
PhD, medical sciences, Obstetrician-gynaecologist, physiological and obstetric department

Roman G. Shmakov

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia

Email: r_shmakov@oparina4.ru
Doctor of Medical Science, Medical director

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