Current methods for estimating the window of implantation in patients undergoing IVF treatment


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The paper provides a systems analysis of the data available in modern scientific literature on current methods for evaluating the markers of the window of implantation and on their search in patients with infertility. It describes the most significant markers of endometrial receptivity and methods for its assessment in infertile patients before embryo transfer in the in vitro fertilization (IVF) program. In consideration of highly contradictory data, further investigations are needed to search for predictors for the best day for implantation and to further understand the processes of synchronization between embryonic and endometrial development in order to enhance the effectiveness of an assisted reproductive technology program.

Full Text

Restricted Access

About the authors

M. I Polovneva

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia

Email: maria_mir18@mail.ru
Postgraduate student at Department of Preservation and Restoration of the Reproductive Function

I. E Korneeva

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia

Email: i_korneeva@oparina4.ru
PhD, Leading Researcher at Department of Preservation and Restoration of the Reproductive Function

O. V Burmenskaya

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia

Email: o_bourmenskaya@oparina4.ru
PhD, Senior Scientist at the Laboratory of Molecular Genetic Methods

References

  1. Корсак В.С., Смирнова А.А., Шурыгина О.В. Регистр центров ВРТ в России. Отчет за 2014 г. Проблемы репродукции. 2016; 22(5): 10-21.
  2. Noyes R. W., Hertig A., Rock J. Dating the endometrial biopsy. Am. J. Obstet. Gynecol. 1975; 122(2): 262-3.
  3. Zhioua A., Elloumi H., Fourati S., Merdassi G., Ben Ammar A., Sajia B.S. et al. Morphometric analysis of the human endometrium during the implantation window. Light and transmission electron microscopy study. J. Gynecol. Obstet. Biol. Reprod. (Paris). 2012; 41(3): 235-42.
  4. Mikolajczyk M., Skrzypczak J., Wirstlein P. No correlation between pinopode formation and LIF and MMP2 expression in endometrium during implantation window. Folia Histochem. Cytobiol. 2011; 49(4): 615-21.
  5. Дюжева Е.В., Коган Е.А., Калинина Е.А., Кузьмичев Л.Н. Принципы индивидуальной гормональной подготовки эндометрия у пациенток с неэффективными попытками ЭКО. Акушерство и гинекология. 2011; 7-2: 39-45.
  6. Левиашвили М.М., Демура Т.А., Мишиева Н.Г., Файзуллина Н.М., Назар енко Т.А., Коган Е.А. Оценка рецептивности эндометрия у пациенток с безуспешными программами экстракорпорального оплодотворения в анамнезе. Акушерство и гинекология. 2012; 4-1: 65-9.
  7. Coughlan C., Sinagra M., Ledger W., Li T.C., Laird S. Endometrial integrin expression in women with recurrent implantation failure after in vitro fertilization and its relationship to pregnancy outcome. Fertil. Steril. 2013; 100(3): 825-30.
  8. Franasiak J.M., Holoch K.J., Yuan L., Schammel D.P., Young S.L., Lessey B.A. Prospective assessment of midsecretory endometrial leukemia inhibitor factor expression versus avß3 testing in women with unexplained infertility. Fertil. Steril. 2014; 101(6): 1724-31.
  9. Margioula-Siarkou C., Prapas Y., Petousis S., Milias S., Ravanos K., Kalogiannidis I. et al. LIF and LIF-R expression in the endometrium of fertile and infertile women: A prospective observational case-control study. Mol. Med. Rep. 2016; 13(6): 4721-8.
  10. Haouzi D., Bissonnette L., Gala A., Assou S., Entezami F., Perrochia H. et al. Endometrial receptivity profile in patients with premature progesterone elevation on the day of HCG administration. Biomed. Res. Int. 2014; 2014: 951937.
  11. Tseng L.H., Chen I., Chen M.Y., Yan H., Wang C.N., Lee C.L. Genome-based expression profiling as a single standardized microarray platform for the diagnosis of endometrial disorder: an array of 126-gene model. Fertil. Steril. 2010; 94(1): 114-9.
  12. Evans G.E., Martinez-Conejero J.A., Phillipson G.T., Simon C., McNoe L.A., Sykes P.H. et al. Gene and protein expression signature of endometrial glandular and stromal compartments during the window of implantation. Fertil. Steril. 2012; 97(6): 1365-73. E1-2.
  13. Chan C., Virtanen C., Winegarden N.A., Colgan T.J., Brown T.J., Greenblatt E.M. Discovery of biomarkers of endometrial receptivity through a minimally invasive approach: a validation study with implications for assisted reproduction. Fertil. Steril. 2013; 100(3): 810-7.
  14. Shi C., Shen H., Fan L.-J., Guan J., Zheng X.-B., Chen X. et al. Endometrial microRNA signature during the window of implantation changed in patients with repeated implantation failure. Chin. Med. J. 2017; 130(5): 566-73.
  15. Garrido-Gomez T., Ruiz-Alonso M., Blesa D., Diaz-Gimeno P., Vilella F., Simon C. Profiling the gene signature of endometrial receptivity: clinical results. Fertil. Steril. 2013; 99(4): 1078-85.
  16. Mahajan N. Endometrial receptivity array: clinical application. J. Hum. Reprod. Sci. 2015; 8(3): 121-9.
  17. Ruiz-Alonso M., Blesa D., Diaz-Gimeno P., Gomez E., Fernandez-Sanches M., Carranza F. et al. The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure. Fertil. Steril. 2013; 100(3): 818-24.
  18. Ruiz-Alonso M., Galindo N., Pellicer A., Simon C.What a difference two days make: “personalized” embryo transfer (pET) paradigm: a case report and pilot study. Hum. Reprod. 2014; 29(6): 1244-7.
  19. Маслова М.А., Смольникова В.Ю., Донников А.Е., Бурменская О.В., Демура Т.А., Таболова В.К., Корнеева И.Е. Оценка значимости молекулярно-генетических маркеров в эндометрии в прогнозировании исхода беременности в программе экстракорпорального оплодотворения. Акушерство и гинекология. 2015; 3: 26-32.
  20. Бурменская О.В., Боженко В.К., Смольникова В.Ю., Калинина Е.А., Корнеева И.Е., Межевитинова Е.А., Донников А.Е., Бейк Е.П., Набиева К.Р., Наумов В.А., Боровиков П.И. Поиск маркеров персонального «окна имплантации» у женщин в программе экстракорпорального оплодотворения с помощью определения транскрипционного профиля генов. Акушерство и гинекология. 2017; 5: 72-80. http://dx.doi.org/10.18565/ aig.2017.5.72-80
  21. Bhagwat S.R., Chandrashekar D.S., Kakar R., Davuluri S., Bajpai A.K., Nayak S. et al. Endometrial receptivity: a revisit to functional genomics studies on human endometrium and creation of HGEx-ERdb. PLoS One. 2013; 8(3): e58419.
  22. Human Gene Expression Endometrial Receptivity database (HGEx-ERdb). Available at: http://resource.ibab.ac.in/HGEx-ERdb/

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies