Hyaluronic acid-enriched embryo transfer medium in assisted reproductive technology programs: mechanism of action and indications for use


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Abstract

The paper carries out a systems analysis of the data available in the current literature on the use of hyaluronic acid-enriched embryo transfer medium to improve the outcomes of assisted reproductive technology (ART) programs. It describes possible mechanisms of action of the hyaluronic acid-enriched embryo transfer medium in the ART programs. Separate attention is paid to the definition of indications for this procedure. How to manage patients with a history of multiple failed IVF attempts has not been def initively determined today. One of the reasons for the failure to implant high-grade quality embryos is the lack of adhesive matrix formation between the embryo and the endometrium. The use of hyaluronic acid-enriched embryo transfer media can be an innovative noninvasive procedure to overcome the problem of implantation failure in ART programs. Older female reproductive age, low-grade quality embryos, and a history of multiple failed IVF attempts are indications for this procedure. Nonetheless, the results of studies in this area are currently extremely controversial.

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About the authors

Andrey Yu. Romanov

Academician V.l. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: romanov1553@yandex.ru
clinical resident

Nataliya P. Makarova

Academician V.l. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: np_makarova@oparina4.ru
PhD, Researcher of the ART department

Nataliya Vitalievna Dolgushina

Academician V.l. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: n_dolgushina@oparina4.ru
M.D., Ph.D., M.P.H., Head of R&D Department

Elena A. Kalinina

Academician V.l. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_kalinina@oparina4.ru
M.D., Ph.D., Head of IVF Department

References

  1. Сыркашева А.Г., Агаршева М.В., Андреева М.Г., Долгушина Н.В., Калинина Е.А., Яроцкая Е.Л. Современные представления о дифференцированном подходе к выбору протокола стимуляции суперовуляции в циклах ЭКО. Акушерство и гинекология. 2016; 5: 38-43.
  2. Ипен С.М., Павлович С.В., Мишиева Н.Г., Абубакиров А.Н., Мартазанова Б.А. Сравнительный анализ эффективности программ вспомогательных репродуктивных технологий в зависимости от триггера овуляции. Акушерство и гинекология. 2017; 6: 99-103.
  3. Ковальская E.B., Сыркашева A.I., Романов А.Ю., Макарова Н.П., Долгушина Н.В. Современные представления о компактизации эмбрионов человека в условиях in vitro. Технологии живых систем. 2017; 14(1): 25-35.
  4. Раманов А.Ю., Ковальская E.B., Макарова Н.П., Сыркашева A.Г., Долгушина Н.В. Использование цейтраферной съемки для оценки качества эмбрионов человека в программах экстракорпорального оплодотворения. Цитология. 2017; 59(7): 462-6.
  5. Syrkasheva A.G., Dolgushina N. V., Romanov A.Y., Burmenskaya О. V., Makarova N.P., Ibragimova E.O. et al. Cell and genetic predictors of human blastocyst hatching success in assisted reproduction. Zygote. 2017; 25(5): 631-6.
  6. Shafei R.A., Syrkasheva A.G., Romanov A. Y., Makarova N.P., Dolgushina N.V., Semenova M.L. Blastocyst hatching in humans. Russ. J. Dev. Biol. 2017; 48(1): 5-15.
  7. Кулакова E.B., Калинина E.A., Трофимов Д.Ю., Макарова Н.П., Хечумян Л.Р., Дударова А.Х. Вспомогательные репродуктивные технологии у супружеских пар с высоким риском генетических нарушений. Преимплантационный генетический скрининг. Акушерство и гинекология. 2017; 8: 21-7.
  8. Долгушина H.B., Сыркашева А.Г., Макарова Н.П., Казакова В.В., Беднягин Л.А., Калинина Е.А. Преимплантационный генетический скрининг у супружеских пар с дисморфизмами ооцитов: анализ затраты - эффективность. Акушерство и гинекология. 2015; 9: 47-55.
  9. Долгушина H.B., Сокур С.А., Горшкова А.Г., Спорышева Л.Н., Калинина Е.А. Преимплантационный генетический скрининг у супружеских пар с пато-зооспермией у мужчин: анализ затраты - эффективность. Акушерство и гинекология. 2014; 4: 51-6.
  10. Singh N., Gupta М., Kriplani A., Vanamail P. Role of Embryo Glue as a transfer medium in the outcome of fresh non-donor in-vitro fertilization cycles. J. Hum. Reprod. Sci. 2015; 8(4): 214-7.
  11. Fancsovits P., Lehner A., Murber A., Kaszas Z., Rigo J., Urbancsek J. Effect of hyaluronan-enriched embryo transfer medium on IVF outcome: a prospective randomized clinical trial. Arch. Gynecol. Obstet. 2015; 291(5): 1173-9.
  12. Meintjes M. Media composition: macromolecules and embryo growth. Methods Mol. Biol. 2012; 912: 107-27.
  13. van Os H.C., Drogendijk A.C., Fetter W.P., Heijtink R.A., Zeilmaker G.H. The influence of contamination of culture medium with hepatitis В. virus on the outcome of in vitro fertilization pregnancies. Am. J. Obstet. Gynecol. 1991; 165(1): 152-9.
  14. Friedler S., Schachter М., Strassburger D., Esther K., Ron El R., Raziel A. A randomized clinical trial comparing recombinant hyaluronan/recombinant albumin versus human tubal fluid for cleavage stage embryo transfer in patients with multiple IVF-embryo transfer failure. Hum. Reprod. 2007; 22(9): 2444-8.
  15. Herrler A., von Rango U., Beier H.M. Embryo-maternal signalling: how the embryo starts talking to its mother to accomplish implantation. Reprod. Biomed. Online. 2003; 6(2): 244-56.
  16. Nakagawa K., Takahashi C., Nishi Y., Jyuen H., Sugiyama R., Kuribayashi Y. et al. Hyaluronan-enriched transfer medium improves outcome in patients with multiple embryo transfer failures. J. Assist. Reprod. Genet. 2012; 29(7): 679-85.
  17. Gardner D.K., Rodriegez-Martinez H., Lane M. Fetal development after transfer is increased by replacing protein with the glycosaminoglycan hyaluronan for mouse embryo culture and transfer. Hum. Reprod. 1999; 14(10): 2575-80.
  18. Girish K.S., Kemparaju K. The magic glue hyaluronan and its eraser hyaluronidase: a biological overview. Life Sci. 2007; 80(21): 1921-43.
  19. Campbell S., Swann H.R., Aplin J.D., Seif M.W., Kimber S.J., Eistein M. CD44 is expressed throughout pre-implantation human embryo development. Hum. Reprod. 1995; 10(2): 425-30.
  20. Yaegashi N., Fujita N., Yajima A., Nakamura M. Menstrual cycle dependent expression of CD44 in normal human endometrium. Hum. Pathol. 1995; 26(8): 862-5.
  21. Afify A.M., Craig S., Paulino A.FG. Temporal variation in the distribution of hyaluronic acid, CD44s, and CD44v6 in the human endometrium across the menstrual cycle. Appl. Immunohistochem. Mol. Morphol. 2006; 14(3): 328-33.
  22. Lim K., Lee B., Kang S., Hwang W. Effects of protein source and energy substrates on the in vitro development of bovine embryos in a two-step culture system. J. Vet. Sci. 2003; 4(1): 73-8.
  23. Stojkovic M., Kölle S., Peinl S., Stojkovic P., Zakhartchenko V., Thompson J.G. et al. Effects of high concentrations of hyaluronan in culture medium on development and survival rates of fresh and frozen-thawed bovine embryos produced in vitro. Reproduction. 2002; 124(1): 141-53.
  24. Loutradi K.E., Prassas I., Bili E., Sanopoulou T., Bontis I., Tarlatzis B.C. Evaluation of a transfer medium containing high concentration of hyaluronan in human in vitro fertilization. Fertil. Steril. 2007; 87(1): 48-52.
  25. Safari S., Razi M.H., Safari S., Razi Y. Routine use of EmbryoGlue(®) as embryo transfer medium does not improve the ART outcomes. Arch. Gynecol. Obstet. 2015; 291(2): 433-7.
  26. Bontekoe S., Heineman M.J., Johnson N., Blake D. Adherence compounds in embryo transfer media for assisted reproductive technologies. Cochrane Database Syst. Rev. 2014; (2): CD007421.
  27. Wu F., Lii R., Bai X., Song X. [Influence of EmbryoGlue on the implantation of embryo and pregnancy outcome in vitro fertilization-embryo transfer]. Zhonghua Fu Chan Ke Za Zhi. 2012; 47(2): 121-4.
  28. Urman B., Yakin K., Ata B., Isiklar A., Balaban B. Effect of hyaluronan-enriched transfer medium on implantation and pregnancy rates after day 3 and day 5 embryo transfers: a prospective randomized study. Fertil. Steril. 2008; 90(3): 604-12.
  29. Check J.H., Summers-Chase D., Yuan W., Swenson K., Horwath D., Press M. “Embryo glue” does not seem to improve chances of subsequent pregnancy in refractory in vitro fertilization cases. Clin. Exp. Obstet. Gynecol. 2012; 39(1): 11-2.

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