Transdermal estrogens in assisted reproductive technology programs


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Abstract

The paper presents historical data on the use of estrogens in gynecology. The advantages of transdermal drug formulations are shown to be the constant rate of release and absorption of the active ingredient, which ensure the minimal variability of its concentrations in the systemic circulation, greater bioavailability, and no effect of the ingredient on the gastrointestinal tract and metabolic profile. The authors analyze the currently available data on the use of transdermal estrogens in assisted reproductive technology programs in the most common clinical scenarios: donor oocyte/embryo and cryopreserved embryo transfers in patients with ovarian anovulation or depletion and a thin endometrium.

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About the authors

Irina E. Korneeva

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: i_korneeva@oparina4.ru
PhD, Leading Researcher at Department of Preservation and Restoration of the Reproductive Function

Tatyana A. Nazarenko

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: t_nazarenko@oparina4.ru
Doctor of Medical Sciences, Professor, Chief Researcher, Moscow Research Institute of Obstetrics and Gynecology.

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