The results of the examination of cervical-vaginal microbiota in pregnant women with threatened preterm birth using a real-time polymerase chain reaction
- Authors: Dobrokhotova Y.E.1, Bondarenko K.R.1, Gushchin A.E.2, Rumyantseva T.A.2, Dolgova T.V1, Kuznetsov P.A.1, Dzhokhadze L.S.2
-
Affiliations:
- N.I. Pirogov Russian National Research Medical University
- Central Research Institute of Epidemiology of Rospotrebnadzor
- Issue: No 11 (2018)
- Pages: 50-59
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/248305
- DOI: https://doi.org/10.18565/aig.2018.11.50-59
- ID: 248305
Cite item
Abstract
Full Text
About the authors
Yuliya E. Dobrokhotova
N.I. Pirogov Russian National Research Medical University
Email: pr.dobrohotova@mail.ru
SPIN-code: 2925-9948
Dr.Med.Sci., Professor, Head of the Department of Obstetrics and Gynecology, Faculty of Medicine
Karina R. Bondarenko
N.I. Pirogov Russian National Research Medical University
Email: karinabond@mail.ru
SPIN-code: 9976-0735
Ph.D., Teaching Assistant at the Department of Obstetrics and Gynecology, Faculty of Medicine
Aleksandr E. Gushchin
Central Research Institute of Epidemiology of Rospotrebnadzor
Email: aguschin1965@pcr.ru
SPIN-code: 3496-6893
Ph.D. (bio.sci.), Head of the Laboratory for Molecular Diagnostics and Epidemiology of Infections of Reproductive Organs
Tat’yana A. Rumyantseva
Central Research Institute of Epidemiology of Rospotrebnadzor
Email: Ivanovatatiana86@yandex.ru
SPIN-code: 4037-5114
Researcher at the Laboratory of Molecular Diagnostics and Epidemiology of Infections of Reproductive Organs, Obstetrician-gynecologist at the Clinical Diagnostics and Research Center
T. V Dolgova
N.I. Pirogov Russian National Research Medical University
Pavel A. Kuznetsov
N.I. Pirogov Russian National Research Medical University
Email: poohsmith@mail.ru
SPIN-code: 6683-4300
Ph.D., Associate Professor at the Department of Obstetrics and Gynecology, Faculty of Medicine
Lela S. Dzhokhadze
Central Research Institute of Epidemiology of Rospotrebnadzor
Email: anton-b1@mail.ru
SPIN-code: 3482-8630
Ph.D., Teaching Assistant at the Department of Obstetrics and Gynecology, Faculty of Medicine
References
- Golde«berg R.L., Culha«e J.F., Lams J.D., Romero R. Epidemiology and causes of preterm birth. Lancet. 2008; 371(9606): 75-84. doi: 10.1016/S0140-6736(08)60074-4.
- Информационный бюллетень ВОЗ №363, ноябрь 2017. Available at: http:// www.who.int/mediacentre/factsheets/fs363/ru/
- Howso«C.P., Kimey M.V., McDougall L., Law«J.E. Born toon soon: Preterm birth matters. Reprod. Health. 2013; 10(Suppl. 1): S1. doi: 10.1186/1742-4755-10-S1-S1.
- Liu L., Oza S., Hoga«D., Chu Y., Peri«J., Zhu J., et al. Global, regional, and national causes of under-5 mortality in 2000-15: an updated systematic analysis with implications for the Sustainable Development Goals. Lancet. 2016; 388(10063): 3027-35. doi: 10.1016/S0140-6736(16)31593-8.
- Curnrngham F.G., Leve«o K.J., Bloom S.L., Hauth J.C., Rouse D.J., Spo«g C.Y., eds. Williams obstetrics. New York: McGraw-Hill Companies; 2010.
- Howso«C.P., Ki««ey M., Law«J.E., eds. Born too soon: the global action report on preterm birth. Recommended citation: March of Dimes, PMNCH, Save the Children, WHO. Geneva: World Health Organization; 2012.
- Gravett M.G., Rube«s C.E., Nu«es T.M., the GAPPS Review Group. Global report on preterm birth and stillbirth (2 of 7): discovery science. BMC Pregnancy and Childbirth. 2010;10(Suppl 1):S2. doi: 10.1186/1471-2393-10-S1-S2.
- Lamo«t R.F. Advances in the prevention of infection-related preterm birth. Front. Immunol. 2015; 6: 566. doi: 10.3389/fimmu.2015.00566.
- Козлов П.В., Иванников Н.Ю., Кузнецов П.А., Богаева И.И. Эпидемиология, этиология и патогенез поздних преждевременных родов. Акушерство, гинекология и репродукция. 2015;9(1):68-76. doi: 10.17749/2313-7347.2015.9.1.068-076.
- Romero R., Dey S.K., Fisher S.J. Preterm labor: one syndrome, many causes. Science. 2014; 345(6198): 760-5. doi: 10.1126/science.1251816.
- Adams Waldorf K.M., McAdams R.M. Influence of infection during pregnancy on fetal development. Reproduction. 2013; 146(5): R151-62. doi: 10.1530/REP-13-0232.
- Do«ders G.G., Va«Calstere«K., Belle«G., Reybrouck R., Va«de«Bosch T., Riphage«I., Va«Lierde S. Predictive value for preterm birth of abnormal vaginal flora, bacterial vaginosis and aerobic vaginitis during the first trimester of pregnancy. BJOG. 2009; 116(10): 1315-24.
- Romero R., Hassa«S.S., Gajer P., Tarca A.L., Fadrosh D.W., Bieda J. et al. The vaginal microbiota of pregnant women who subsequently have spontaneous preterm labor and delivery and those with a normal delivery at term. Microbiome. 2014; 2: 18. doi: 10.1186/2049-2618-2-18.
- Low N., Redmo«d S., Uusküla A., va«Berge«J., Ward H., A«derse«B., Götz H. Screening for genital chlamydia infection. Cochrane Database Syst. Rev. 2016; (9): CD010866. doi: 10,1002 / 14651858.CD010866.pub2
- Brocklehurst P., Gordo«A., Heatley E., Milan S.J. Antibiotics for treating bacterial vaginosis in pregnancy. Cochrane Database Syst. Rev. 2013; (1): CD000262. doi: 10.1002/14651858.CD000262.pub4.
- Amsel R., Totte«P.A., Spiegel C.A., Che«K.C., Esche«bach D., Holmes K.K. Nonspecific vaginitis. Diagnostic criteria and microbial and epidemiologic associations. Am. J. Med. 1983; 74(1): 14-22. doi: 10.1016/0002-9343(83)91137-3.
- Румянцева Т.А., Гущин А.Е., Дондерс Г. Международная валидация набора реагентов для диагностики бактериального вагиноза. В. кн.: Молекулярная диагностика-2014. Сборник трудов VIII Всероссийской научно-практической конференции с международным участием. М.; 2014; т.1: 153.
- Rumyantseva T.A., Bellen G., Savochkina Y.A., Guschin A.E., Donders G.G. Diagnosis of aerobic vaginitis by quantitative real-time PCR. Arch. Gynecol. Obstet. 2016; 294(1): 109-14. doi: 10.1007/s00404-015-4007-4.
- Румянцева Т.А., Савочкина Ю.А., Долгова Т.И., Зайцева С.В., Кахерская М.А., Кудрявцева Л.В., Гущин А.Е. Диагностика вульвовагинального кандидоза: сопоставление информативности клинических данных и результатов лабораторных исследований. Акушерство и гинекология. 2015; 3: 55-61.
- Румянцева Т.А., Варламова А.В., Гущин А.Е., Безруков В.М. Сравнение тестов для количественной оценки Ureaplasma parvum, Ureaplasma urealyticum, Mycoplasma hominis: «Mycoplasma Duo», «Уреаплазма Микротест», «Микоплазма Микротест» и «Флороценоз-Микоплазмы». Клиническая лабораторная диагностика. 2014; 8: 52-7.
- Pri«ce A.L., Chu D.M., Seferovic M.D., Antony K.M., Ma J., Aagaard K.M. The Perinatal microbiome and pregnancy: moving beyond the vaginal microbiome. Cold Spring Harb. Perspect. Med. 2015; 5(6): pii: a023051. doi: 10.1101/cshper-spect.a023051.
- DiGiulio D.B., Callahan B.J., McMurdie P.J., Costello E.K., Lyell D.J., Robaczewska A. et al. Temporal and spatial variation of the human microbiota during pregnancy. Proc. Natl. Acad. Sci. USA. 2015; 112(35): 11060-5. doi: 10.1073/pnas.1502875112.
- Leitich H., Bod«er-Adler B., Bru«bauer M., Kaider A., Egarter C., Husslei«P. Bacterial vaginosis as a risk factor for preterm delivery: a meta-analysis. Am. J. Obstet. Gynecol. 2003; 189(1): 139-47. doi: 10.1067/mob.2003.339.
- Do«ders G., Belle«G., Rezeberga D. Aerobic vaginitis in pregnancy. BJOG. 2011; 118(10): 1163-70. doi: 10.1111/j.1471-0528.2011.03020.x.
- Cotch M.F., Hillier S.L., Gibbs R.S., Esche«bach D.A. Epidemiology and outcomes associated with moderate to heavy candida colonization during pregnancy. Vaginal Infections and Prematurity Study Group. Am. J. Obstet. Gynecol. 1998;178(2): 374-80. doi: 10.1016/S0002-9378(98)80028-8.
- Roberts C.L., Algert C.S., Richard K.L., Morris J.M. Treatment of vaginal candidiasis for prevention of preterm birth: a systematic review and meta-analysis. Syst. Rev. 2015; 4: 31. doi: 10.1186/s13643-015-0018-2.
- Доброхотова Ю.Э., Боровкова Е.И., Бондаренко К.Р. Кандидозный вульвовагинит: состояние изученности проблемы. Российский вестник акушера-гинеколога. 2017; 17(3): 108-11.
- Holzer I., Farr A., Kiss H., Hagmann M., Petricevic L. The colonization with Candida species is more harmful in the second trimester of pregnancy. Arch. Gynecol. Obstet. 2017; 295(4): 891-5. doi: 10.1007/ s00404-017-4331-y.
- Lis R., Rowhani-Rahbar A., Manhart L.E. Mycoplasma genitalium infection and female reproductive tract disease: A meta-analysis. Clin. Infect. Dis. 2015; 61(3): 418-26. doi: 10.1093/cid/civ312.
- Liu B., Roberts C.L., Clarke M., Jorm L., Hunt J., Ward J. Chlamydia and gonorrhoea infections and the risk of adverse obstetric outcomes: a retrospective cohort study. Sex. Transm. Infect. 2013; 89(8): 672-8. doi: 10.1136/ sextrans-2013-051118.
- Rours G.I., Duijts L., Moll H.A., Arends L.R., de Groot R., Jaddoe V.W. et al. Chlamydia trachomatis infection during pregnancy associated with preterm delivery: a population-based prospective cohort study. Eur. J. Epidemiol. 2011; 26(6): 493-502. doi: 10.1007/s10654-011-9586-1.
- Sobel J.D., Subramanian C., Foxman B., Fairfax M., Gygax S.E. Mixed vaginitis-more than coinfection and with therapeutic implications. Curr. Infect. Dis. Rep. 2013; 15(2): 104-8. doi: 10.1007/s11908-013-0325-5.
- Swidsinski A., Mendling W., Loening-Baucke V., Ladhoff A., Swidsinski S., Hale L.P., Lochs H. Adherent biofilms in bacterial vaginosis. Obstet. Gynecol. 2005; 106(5, Pt 1): 1013-23. doi: 10.1097/01.A0G.0000183594.45524.d2.
- Taylor-Robinson D. Mollicutes in vaginal microbiology: Mycoplasma hominis, Ureaplasma urealyticum, Ureaplasma parvum and Mycoplasma genitalium. Res. Microbiol. 2017; 168(9-10): 875-81. doi: 10.1016/ j.resmic.2017.02.009.
- Бондаренко К.Р., Озолиня Л.А., Бондаренко В.М., Шпирко В.О. Особенности влагалищной микроэкосистемы в период гестации (обзор литературы). Вестник Российского государственного медицинского университета. 2014; 4:6-11.