Specific features of the expression of syndecan-1 and heparanase in the epithelium of Stage III ovarian endometrioid cysts


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Objective. To investigate the expression of syndecan-1 and heparanase in the lining of the ovarian endometrioma capsule in reproductive-aged women in the proliferative phase of the cycle, by assessing the severity of inflammatory infiltration and the correlation with pain syndrome. Subjects and methods. Twenty patients aged 27.7 ± 5.3 years with Stage III ovarian endometrioid cysts were examined using a semiquantitative immunohistochemical assessment of the expression of syndecan-1 and heparanase in the capsule of resected endometriomas, as well as a statistical analysis. Results. The expression of heparanase in the epithelial nuclei with sufficient statistical significance (p < 0.0001) shows a strong positive correlation with a visual analog scale pelvic pain scores of 3-5 (r = 0.902) and with subepithelial inflammatory infiltration (r = 0.887), as well as a strong negative correlation with the manifestations of cytogenic stromal fibrosis (r = -0.902). Conclusion. The pronounced heparanase expression in the epithelium of ovarian endometriomas is associated with inflammatory cell infiltration and the presence of pain syndrome; no significant regularities were found for syndecan-1.

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作者简介

Igor’ Marinkin

Novosibirsk State Medical University, Ministry of Health of Russia

Email: +7(383)222-32-04. rector@ngmu.ru
doctor of medical sciences, professor, the head of the Obstetrics and Gynecology Department

Yulia Timofeeva

Novosibirsk State Medical University, Ministry of Health of Russia

Email: julie_srg@mail.ru
assistent of the Obstetrics and Gynecology Department

Vitaliy Kuleshov

Novosibirsk State Medical University, Ministry of Health of Russia

Email: kuleshov_vm@mail.ru
doctor of medical sciences, professor, professor of the Obstetrics and Gynecology Department

Alexandr Volchek

Maternity Hospital Two, Novosibirsk

Email: alexander@volcheck.ru
physician-gynecologist of the State Budget Health Foundation

Konstantin Makarov

Novosibirsk State Medical University, Ministry of Health of Russia

Email: fdpngma@mail.ru
doctor of medical sciences, docent, professor of the Obstetrics and Gynecology Department

Vladimir Omigov

Novosibirsk State Medical University, Ministry of Health of Russia

Email: omigov@vector.nsc.ru
candidate of medical sciences, senior researcher of laboratory of cellular biology and fundamental basis of reproduction of NSMU’s Central scientific laboratory

Svetlana Aidagulova

Novosibirsk State Medical University, Ministry of Health of Russia

Email: s.aydagulova@gmail.com
doctor of biological sciences, professor, head of laboratory of cellular biology and fundamental basis of reproduction of NSMU’s Central scientific laboratory

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