DUMANOVSKAYA ENDOMETRIAL LESION'S PATTERN IN DIFFERENT AGE GROUPS


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Background. Endometrial polyps (EP) take an important part in the structure of intrauterine pathology and could be associated with abnormal uterine bleeding (AUB), infertility and the risk of endometrial cancer (EC) development. The data concerning EP’s prevalence and combination with other endometrium pathology’s forms in women of different age varies widely. It causes difficulties for understanding the magnitude of the problem and finding solutions for management. The aim. To evaluate the prevalence of EP and other endometrium conditions at different ages. Materials and methods. Based on the study of 4059 histological samples we analysed the EP’s prevalence and association with other intrauterine pathology in women of different age groups. Results. EP was diagnosed in 27.4% of samples. It’s frequency varied from 21.7 to 27.3% in reproductive age and - 45% in postmenopausal women. 19.8% of EP were concomitant with chronic endometritis (CE), 3.7% with endometrial hyperplasia (EH). Conclusions. EP take 1st place in the structure of intrauterine pathology during all age periods. Their prevalence is 2.7 times higher than CE, and 4.5 times higher than EH.

Full Text

Restricted Access

About the authors

Ilya A. Ivanov

National Medical Research Center of Obstetrics, Gynecology, and Perinatology Academician named after V.I. Kulakov, Ministry of Health of Russia

Email: g_chernukha@oparina4.ru
postgraduate student, Department of endocrinological gynecology Moscow 117997, Ac. Oparina str. 4, Russia

Alexandra V. Asaturova

National Medical Research Center of Obstetrics, Gynecology, and Perinatology Academician named after V.I. Kulakov, Ministry of Health of Russia

Email: a_asaturova@oparina4.ru
Ph.D., senior scientific researcher, Pathology department Moscow 117997, Ac. Oparina str. 4, Russia

Madina R. Dumanovskaya

National Medical Research Center of Obstetrics, Gynecology, and Perinatology Academician named after V.I. Kulakov, Ministry of Health of Russia

Email: doctor.i.ivanov@yandex.ru
Ph.D., scientific researcher, Department of endocrinological gynecology Moscow 117997, Ac. Oparina str. 4, Russia

Galina E. Chernukha

National Medical Research Center of Obstetrics, Gynecology, and Perinatology Academician named after V.I. Kulakov, Ministry of Health of Russia

Email: m_dumanovskaya@oparina4.ru
M.D., professor, Department of endocrinological gynecology Moscow 117997, Ac. Oparina str. 4, Russia

References

  1. Fabres C., Alam V., Balmaceda J., Zegers-Hochschild F., Mackenna A., Fernandez E. Comparison of ultrasonography and hysteroscopy in the diagnosis of intrauterine lesions in infertile women. J. Am. Assoc. Gynecol. Laparosc. 1998; 5(4): 375-8.
  2. DeWaay D.J., Syrop C.H., Nygaard I.E., Davis W.A., Van Voorhis B.J. Natural history of uterine polyps and leiomyomata. Obstet. Gynecol. 2002; 100(1): 3-7.
  3. Lieng M., Istre O, Sandvik L., Qvigstad E. Prevalence, 1-year regression rate, and clinical significance of asymptomatic endometrial polyps: cross-sectional study. J. Minim. Invasive Gynecol. 2009; 16(4): 465-71.
  4. Clark T.J., Gupta J.K. Handbook of outpatient hysteroscopy: a complete guide to diagnosis and therapy. Boca Raton, FL: CRC Press; 2005.
  5. Fatemi H.M., Kasius J.C., Timmermans A., van Disseldorp J., Fauser B.C., Devroey P., Broekmans FJ. Prevalence of unsuspected uterine cavity abnormalities diagnosed by office hysteroscopy prior to in vitro fertilization. Hum. Reprod. 2010; 25(8): 1959-65.
  6. Capmas P., Pourcelot A.G., Giral E., Fedida D., Fernandez H. Office hysteroscopy: A report of 2402 cases. J. Gynecol. Obstet. Biol. Reprod. (Paris). 2016; 45(5): 445-50.
  7. Abid M., Hashmi A.A., Malik B., Haroon S., Faridi N., Edhi M.M., Khan M. Clinical pattern and spectrum of endometrial pathologies in patients with abnormal uterine bleeding in Pakistan: need to adopt a more conservative approach to treatment. BMC Women’s Health. 2014; 14: 132.
  8. Dreisler E., Stampe Sorensen S., Ibsen P.H., Lose G. Prevalence of endometrial polyps and abnormal uterine bleeding in a Danish population aged 20-74 years. Ultrasound Obstet. Gynecol. 2009; 33(1): 102-8.
  9. Inal Z.O., Inal H.A., Kucukosmanoglu I., Kucukkendirci H. Assessment of endometrial sampling and histopathological results: analysis of 4,247 cases. Eurasian J. Med. 2017; 49(1): 44-7.
  10. Anastasiadis P.G., Koutlaki N.G., Skaphida P.G., Galazios G.C., Tsikouras P.N., Liberis V.A. Endometrial polyps: prevalence, detection, and malignant potential in women with abnormal uterine bleeding. Eur. J. Gynaecol. Oncol. 2000; 21(2): 180-3.
  11. Clark T.J., Stevenson H. Endometrial polyps and abnormal uterine bleeding (AUB-P) - what is the relationship; how are they diagnosed and how are they treated? Best Pract. Res. Clin. Obstet. Gynaecol. 2017; 40: 89-104.
  12. Cicinelli E., Trojano G., Mastromauro M., Vimercati A., Marinaccio M., Mitola P.C. et al. Higher prevalence of chronic endometritis in women with endometriosis: a possible etiopathogenetic link. Fertil. Steril. 2017; 108(2): 289-295. e1.
  13. Гомболевская Н.А., Марченко Л.А., Коган Е.А. Современные методы лечения пациенток с хроническим эндометритом. Акушерство и гинекология. 2015; 12: 39-45
  14. Никитина Т.И., Осадчев В.Б., Бабков К.В., Мухамедзянова В.М. Структура аномальных маточных кровотечений у женщин репродуктивного возраста. Применение современной классификации PALM-COEIN. Фарматека. 2016; 3: 47-51
  15. Jetley S., Rana S., Jairajpuri Z.S. Morphological spectrum of endometrial pathology in middle-aged women with atypical uterine bleeding: A study of 219 cases. J. Midlife Health. 2013; 4(4): 216-20.
  16. Думановская М.Р., Чернуха Г.Е., Асатурова А.В., Коган Е.А. Частота выявления и структура гиперплазии эндометрия в различные возрастные периоды. Акушерство и гинекология. 2015; 3: 40-4.
  17. Kucur S.K., Şencan H., Yüksel K.B., Deger A. Evaluation of endometrial biopsy results in our clinic; analysis of 744 cases. Zeynep Kamil Tip Bulteni. 2014; 45: 146-50.
  18. Табакман Ю.Ю., Рылов А.Л. Золотой стандарт в диагностике рака эндометрия. Медицинский вестник. 2014; 11 марта, №7.
  19. Hatasaka H. Clinical management of the uterine factor in infertility. Clin. Obstet. Gynecol. 2011; 54(4): 696-709.
  20. de Azevedo J.M., de Azevedo L.M., Freitas F., Wender M.C. Endometrial polyps: when to resect? Arch. Gynecol. Obstet. 2016; 293(3): 639-43.
  21. Lieng M., Istre O., Qvigstad E. Treatment of endometrial polyps: a systematic review. Acta Obstet. Gynecol. Scand. 2010; 89(8): 992-1002.
  22. Baiocchi G., Manci N., Pazzaglia M., Giannone L., Burnelli L., Giannone E. et al. Malignancy in endometrial polyps: a 12-year experience. Am. J. Obstet. Gynecol. 2009; 201(5): 462. e1-4.
  23. Elfayomy A.K., Soliman B.S. Risk factors associated with the malignant changes of symptomatic and asymptomatic endometrial polyps in premenopausal women. J. Obstet. Gynaecol. India. 2015; 65(3): 186-92.
  24. Tanos V., Berry K.E., Seikkula J., Abi Raad E., Stavroulis A., Sleiman Z. et al. The management of polyps in female reproductive organs. Int. J. Surg. 2017; 43: 7-16.
  25. Topcu H.O., Erkaya S., Guzel A.I., Kokanali M.K., Sarikaya E., Muftuoglu K.H., Doganay M. Risk factors for endometrial hyperplasia concomitant endometrial polyps in pre- and post-menopausal women. Asian Pac. J. Cancer Prev. 2014; 15(13): 5423-5.
  26. Carvalho E.M., Aguiar E.N., Tomioka R., de Oliveira R.M., Erantz N., Ueno J. Functional endometrial polyps in infertile asymptomatic patients: a possible evolution of vascular changes secondary to endometritis. Eur. J. Obstet. Gynecol. Reprod. Biol. 2013; 170(1): 152-6.
  27. Horsburgh S., Robson-Ansley P., Adams R. Exercise and inflammation-related epigenetic modifications: focus on DNA methylation. Exerc. Immunol. Rev. 2015;21:26-41.
  28. Paradisi R., Rossi S., Scifo M.C., Dall’O E., Battaglia C., Venturoli S. Recurrence of endometrial polyps. Gynecol. Obstet. Invest. 2014; 78(1): 26-32.
  29. Yang J.H., Chen C.D., Chen S.U., Yang Y.S., Chen M.J. Factors influencing the recurrence potential of benign endometrial polyps after hysteroscopic polypectomy. PLoS One. 2015; 10(12): e0144857.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2018 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies