BLOOD CYTOKINE LEVELS IN NEONATES BORN TO MOTHERS WITH CANCER WHO RECEIVED ANTITUMOR CHEMOTHERAPY DURING PREGNANCY


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Abstract

Objective. To determine the levels of cytokines, chemokines, and growth factors in the peripheral blood of women with cancer who took antitumor chemotherapy during pregnancy and in the blood of their neonates. Subjects and methods. Multiplex analysis was used to estimate the levels of17 factors in the plasma of women taking antitumor chemotherapy during pregnancy as in the umbilical cord and venous blood of their babies. A comparison group consisted of women with physiological pregnancy and their neonates. Results. The cytokine-producing ability of immune cells relative to the corresponding indicators in the comparison group was reduced in women with cancer who took antitumor chemotherapy during pregnancy. The medications used by the mother did not have a substantial effect on the umbilical cord blood level of cytokines in newborn infants. By the end of the neonatal period, the babies had lower blood concentrations of IL-6, IL-8, IL-9, IL-12, MCP-1, MIP-1β, VEGF, and GM-CSF than those aged 3 days of life. Conclusion. The use of antitumor chemotherapy during pregnancy lowers the secretory activity of the immune cells of women and has no significant effect on the level of cytokines, chemokines, and growth factors in the umbilical cord blood plasma of neonates.

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About the authors

Anastasiya S. Zhukova

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia

Email: a_belyaeva@oparina4.ru
research worker in Laboratory of clinical immunology Moscow 117997, Ac. Oparina str. 4, Russia

Mziya I. Makieva

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia

Email: m_makieva@oparina4.ru
neonatologist, pediatrician, the Head of the clinical work of the Department of newborns Moscow 117997, Ac. Oparina str. 4, Russia

Lyudmila V. Vanko

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia

Email: lvanko@mail.ru
Doctor of Medicine, professor, leading research worker in Laboratory of clinical immunology Moscow 117997, Ac. Oparina str. 4, Russia

Valentina V. Vtorushina

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia

Email: vtorushina@inbox.ru
PhD in medical sciences, doctor of laboratory diagnostics in Laboratory of Clinical Immunology Moscow 117997, Ac. Oparina str. 4, Russia

Natalia K. Matveeva

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia

Email: matveeva_nk@mail.ru
PhD in biological sciences, senior researcher in Laboratory of clinical immunology Moscow 117997, Ac. Oparina str. 4, Russia

Tatiana A. Tsoy

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia

Email: t_tsoy@oparina4.ru
neonatologist of the Department of newborns Moscow 117997, Ac. Oparina str. 4, Russia

Maria V. Volochaeva

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia

Email: m_volochaeva@oparina4.ru
PhD in medical sciences, obstetrician-gynecologist of the obstetric department of physiological Moscow 117997, Ac. Oparina str. 4, Russia

Leila A. Timofeeva

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia

Email: l_timofeeva@oparina4.ru
PhD in medical sciences, the Head of the Department of newborns Moscow 117997, Ac. Oparina str. 4, Russia

Lyudmila V. Krechetova

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia

Email: k_l_v_@mail.ru
PhD in medical sciences, the Head of Laboratory of clinical immunology Moscow 117997, Ac. Oparina str. 4, Russia

Viktor V. Zubkov

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia

Email: v_zubkov@oparina4.ru
Doctor of Medicine, the Head of the Department of Neonatology and Pediatrics Moscow 117997, Ac. Oparina str. 4, Russia

Roman G. Shmakov

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia

Email: r_shmakov@oparina4.ru
Doctor of Medicine, Head Physician Moscow 117997, Ac. Oparina str. 4, Russia

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