Biochemical tests for the diagnosis of premature rupture of membranes


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Abstract

According to the results of clinical studies published in English-language and Russian literatures in open-access databases, the author has determined the importance and efficiency of biochemical tests for the diagnosis of premature rupture of membranes. Placental alpha microglobulin-1 (PAMG-1) has a lower detection limit of amniotic fluid than insulin-like growth factor binding protein-1 (IGFBP-1), with increased sensitivity (at 1:40 and 1:80 dilutions; p < 0.05), shorter response time, and better reproducibility (p < 0.05). The specificity and positive predictive value of PAMG-1 are considerably higher than those of IGFBP-1. The test kit for PAMG-1 is most effective, as compared to that for IGFBP-1, and can help avoid misdiagnosis and unnecessary hospitalization.

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About the authors

Oleg R. Baev

National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russia

Email: o_baev@oparina4.ru
MD, professor, head of the maternity department

Galina B. Dikke

F.I. Inozemtsev Academy of Medical Education

Email: galadikke@yandex.ru
doctor of medical sciences, associate professor, Professor of the Department of Obstetrics and Gynecology with a course of reproductive medicine

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