Experience with interferon-gamma in the therapy of sexually transmitted viral infections
- Authors: Rakhmatulina M.R.1, Bolshenko N.V.2,3
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Affiliations:
- State Research Center-Bumasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
- Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
- Moscow Regional Clinical Dermatovenereology Dispensary
- Issue: No 12 (2018)
- Pages: 149-156
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/248385
- DOI: https://doi.org/10.18565/aig.2018.12.149-156
- ID: 248385
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Open Access
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Abstract
Objective. To investigate the efficacy and safety of Ingaron (interferon-gamma) in the combined therapy of sexually transmitted viral infections (STVIs). Subjects and methods. The investigation included 26 patients diagnosed with anogenital herpetic infection (Subgroups 1A and IB) and 64 patients with anogenital (venereal) warts (Subgroups 2A, 2B, 2C, and 2D). Subgroup 1A received combined therapy with acyclovir and Ingaron; Subgroup IB took acyclovir only; Subgroup 2A had Ingaron in combination with cryodestruction; Subgroup 2B received cryodestruction; and Subgroup 2C took Ingaron in combination with destruction with Solcoderm; Subgroup 2D had destruction with Solcoderm. Results. Recurrent anogenital herpetic infection was absent in 92.9% of the patients receiving combined therapy with acyclovir and Ingaron and in 58.3% of those on acyclovir therapy. In patients with anogenital warts, the efficiency of combined therapy (Ingaron + cryodestruction; Ingaron + Solcoderm) exceeded that of therapy with cryodestruction only or with Solcoderm: 94.1, 93.3, 58.8, and 40.0%, respectively. During therapy, there were no serious adverse events or clinically significant changes in the general clinical and biochemical blood tests. Conclusion. The use of Ingaron in the combined therapy of viral STVIs demonstrates a high clinical efficacy and safety profile and assists in reducing the rate of recurrence.
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About the authors
Margarita R. Rakhmatulina
State Research Center-Bumasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Email: ra.marg@yandex.ru
MD, professor of the Department a dermatovenereology and cosmetology with a course of clinical laboratory diagnostics
Natalia V. Bolshenko
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; Moscow Regional Clinical Dermatovenereology DispensaryPhD, the head researcher; The chief of the consultative-diagnostic department
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