The molecular genetic and phenotypic features of synanthropic and pathogenic Gardnerella vaginalis strains


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Abstract

The authors analyzed the data of modern scientific literature on the molecular genetic and phenotypic features of synanthropic and pathogenic Gardnerella vaginalis strains isolated from the vaginal discharge of patients with bacterial vaginosis, as well as the relationship of the characteristics of the strains to the development of bacterial vaginosis. The data of foreign and Russian articles found in Pubmed and eLIBRARY on the investigation topic were considered. There have been recently conflicting data on a relationship of the molecular genetic and phenotypic features of G. vaginalis strains to the development of bacterial vaginosis. Although bacterial vaginosis has been known since ancient times, it is not yet possible to radically advance our understanding of the mechanisms of the symptomatic and asymptomatic course of the disease and its recurrence. However, significant advances in the development of molecular biology give hope for detecting molecular genetic markers, which make it possible to predict the efficiency of etiotropic therapy for bacterial vaginosis and the possibility of its recurrences.

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About the authors

Tatyana V. Priputnevich

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of Ministry of Health of Russian Federation

Email: t_priputnevich@oparina4.ru
MD, head of the Department of Microbiology and Clinical Pharmacology

Vera V. Muravieva

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of Ministry of Health of Russian Federation

Email: v_muravieva@oparina4.ru
candidate of biological science, senior researcher at the Laboratory of Microbiology, Department of Microbiology and Clinical Pharmacology

Aleksey B. Gordeev

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of Ministry of Health of Russian Federation

Email: a_gordeev@oparina4.ru
сandidate of biological science, senior researcher at the Laboratory of Microbiology, Department of Microbiology and Clinical Pharmacology

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