Embryo cultivation in the medium containing granulocyte-macrophage colony-stimulating factor in the ART programs


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Abstract

Objective. The review gives the data available in the modern literature on the role of granulocyte-macrophage colony-stimulating factor (GM-CSF) and embryo cultivation in the medium containing the factor in the treatment of infertility using assisted reproductive technology (ART) techniques. Material and methods. The review includes data from foreign and Russian articles found in Pubmed on this topic. Results. The paper describes the role of GM-CSF in early embryonic development and subsequent implantation when using the GM-CSF-containing medium and discusses the effectiveness of this approach in ART programs. Conclusion. The results of the investigations performed confirm the relevance of using the GM-CSF-containing medium for in vitro embryo culturing, which can create conditions for obtaining better quality embryos, increasing the frequency of pregnancy, and preventing its termination, and giving birth to healthy babies due to the use of ART programs.

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About the authors

Svetlana A. Iarygina

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia

Email: s.a.iarygina@yandex.ru
post-graduate student, Department of Assistive Technologies in Infertility Treatment

Veronika Yu. Smolnikova

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia

Email: veronika.smolnikova@mail.ru
PhD, leading researcher, Department of Assistive Technologies in Infertility Treatment

Mikhail Yu. Bobrov

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia

Email: mbobr@mail.ru
MD, head of the Laboratory of Molecular Pathophysiology

Chupalav M. Eldarov

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia

Email: ch_eldarov@oparina4.ru
senior researcher of the Laboratory of Molecular Pathophysiology

Natalia P. Makarova

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia

Email: np_makarova@oparina4.ru
PhD, researcher of IVF Department

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