Molecular mechanisms of and risk factors for endometriosis


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The paper carries out a systems analysis of the data available in the current literature on the etiopathogenesis and risk factors of endometriosis. It considers the current data of foreign and Russian articles found in Pubmed on this topic. The main etiological hypotheses and molecular mechanisms of endometriosis are given; risk factors for its development are described. According to modern concepts, endometriosis is an etiologically heterogeneous disease, the basis of which is a complex set of hormonal, immunological, inflammatory, genetic, and epigenetic mechanisms. The risk factors for endometriosis are being actively studied, but the results obtained are ambiguous and often contradictory.

Full Text

Restricted Access

About the authors

Irina V. Ponomarenko

Belgorod State National Research University

Email: ponomarenko_i@bsu.edu.ru
MD, associate professor of the Department of Biomedical Disciplines of the Medical Institute

Alexey V. Polonikov

Kursk State Medical University

Email: polonikovav@kursksmu.net
MD, Professor, Head of the Department of Biology, Medical Genetics and Ecology

Mikhail I. Churnosov

Belgorod State National Research University

Email: churnosov@bsu.edu.ru
MD, professor, head of the Department of Biomedical Disciplines Medical Faculty

References

  1. Адамян Л.В., ред. Эндометриоз: диагностика, лечение и реабилитация. Федеральные клинические рекомендации по ведению больных. М.: Российское общество акушеров-гинекологов, ФГБУ «Научный Центр акушерства, гинекологии и перинатологии им. В. И. Кулакова» Минздрава РФ; 2013. 66с.
  2. Anglesio M.S., Papadopoulos N., Ayhan A., Nazeran T.M., Noë M., Horlings H.M. et al. Cancer-associated mutations in endometriosis without cancer. N. Engl. J. Med. 2017; 376(19): 1835-48. https://dx.doi.org/10.1056/NEJMoa1614814.
  3. Surrey E., Carter C.M., Soliman A.M., Khan S., DiBenedetti D.B., Snabes M.C. Patient-completed or symptom-based screening tools for endometriosis: a scoping review. Arch. Gynecol. Obstet. 2017; 296(2): 153-65. https://dx.doi.org/10.1007/s00404-017-4406-9.
  4. Soliman A.M., Yang H., Du E.X., Kelley C., Winkel C. The direct and indirect costs associated with endometriosis: a systematic literature review. Hum. Reprod. 2016; 31(4): 712-22. https://dx.doi.org/10.1093/humrep/dev335.
  5. Киселев В.И., Сидорова И.С., Унанян А.Л., Муйжнек Е.Л. Гиперпластические процессы органов женской репродуктивной системы: теория и практика. М.: МЕДПРАКТИКА-М; 2010. 468с.
  6. Адамян Л.В., Фархат К.Н., Макиян З.Н., Савилова А.М. Молекулярнобиологическая характеристика эутопического и эктопического эндометрия (обзор литературы). Проблемы репродукции. 2015; 21(5): 8-16. https://dx.doi.org/10.17116/repro20152158-16.
  7. Mehedintu C., Plotogea M., Ionescu S., Antonovici M. Endometriosis still a challenge. J. Med. Life. 2014; 7(3): 349-57.
  8. Sourial S., Tempest N., Hapangama D.K. Theories on the pathogenesis of endometriosis. Int. J. Reprod. Med. 2014; 2014: 179515. https://dx.doi.org/10.1155/2014/179515.
  9. Ahn S.H., Monsanto S.P., Miller C., Singh S.S., Thomas R., Tayade C. Pathophysiology and immune dysfunction in endometriosis. Biomed. Res. Int. 2015; 2015: 795976. https://dx.doi.org/10.1155/2015/795976.
  10. Ярмолинская М.И., Айламазян Э.К. Генитальный эндометриоз. Различные грани проблемы. СПб.: Эко-Вектор; 2017. 615с.
  11. Адамян Л.В., Азнаурова Я.Б. Молекулярные аспекты патогенеза эндометриоза. Проблемы репродукции. 2015; 21(2): 66-77. https://dx.doi.org/10.17116/repro201521266-77.
  12. Zhao Y., Gong P., Chen Y., Nwachukwu J.C., Srinivasan S., Ko C. et al. Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis. Sci. Transl. Med. 2015; 7(271): 271ra9. https://dx.doi.org/10.1126/scitranslmed.3010626.
  13. Han S.J., Jung S.Y., Wu S.-P, Hawkins S.M., Park M.J., Kyo S. et al. Estrogen Receptor ß modulates apoptosis complexes and the inflammasome to drive the pathogenesis of endometriosis. Cell. 2015; 163(4): 960-74. https://dx.doi.org/10.1016/j.cell.2015.10.034.
  14. Monsivais D., Dyson M.T., Yin P., Coon J.S., Navarro A., Feng G. et al. ERß- and prostaglandin E2-regulated pathways integrate cell proliferation via Ras-like and estrogen-regulated growth inhibitor in endometriosis. Mol. Endocrinol. 2014; 28(8): 1304-15. https://dx.doi.org/10.1210/me.2013-1421.
  15. Salmeri F.M., Laganà A.S., Sofo V., Triolo O., Sturlese E., Retto G. et al. Behavior of tumor necrosis Factor-а and tumor necrosis factor receptor 1/tumor necrosis factor receptor 2 system in mononuclear cells recovered from peritoneal fluid of women with endometriosis at different stages. Reprod. Sci. 2015; 22(2): 165-72. https://dx.doi.org/10.1177/1933719114536472.
  16. Sikora J., Mielczarek-Palacz A., Kondera-Anasz Z. Imbalance in cytokines from interleukin-1 family - role in pathogenesis of endometriosis. Am. J. Reprod. Immunol. 2012; 68(2): 138-45. https://dx.doi.org/10.1111/j.1600-0897.2012.01147.x.
  17. Nothnick W., Alali Z. Recent advances in the understanding of endometriosis: the role of inflammatory mediators in disease pathogenesis and treatment. F1000Res. 2016; 5. pii: F1000 Faculty Rev-186. https://dx.doi.org/10.12688/f1000research.7504.1.
  18. Burney R.O., Giudice L.C. Pathogenesis and pathophysiology of endometriosis. Fertil. Steril. 2012; 98(3): 511-9. https://dx.doi.org/10.1016/j.fertnstert.2012.06.029.
  19. Rahmioglu N., Montgomery G.W., Zondervan K.T. Genetics of endometriosis. Womens Health (Lond.). 2015; 11(5): 577-86. https://dx.doi.org/10.2217/whe.15.41.
  20. Baranov V., Malysheva O., Yarmolinskaya M. Pathogenomics of endometriosis development. Int. J. Mol. Sci. 2018; 19(7). pii: E1852. https://dx.doi.org/10.3390/ijms19071852.
  21. Радзинский В.Е., Алтухова О.Б. Молекулярно-генетические детерминанты бесплодия при генитальном эндометриозе. Научные результаты биомедицинских исследований. 2018; 4(3): 21-30. https://dx.doi.org/10.18413/2313-8955-2018-4-3-0-3.
  22. Matalliotakis M., Zervou M.I., Eliopoulos E., Matalliotaki C., Rahmioglu N., Kalogiannidis I. et al. The role of IL-16 gene polymorphisms in endometriosis. Int. J. Mol. Med. 2018; 41(3): 1469-76.
  23. Демакова Н.А. Молекулярно-генетические характеристики пациенток с гиперплазией и полипами эндометрия. Научный результат. Медицина и фармация. 2018; 4(2):26-39. doi: 10.18413/2313-8955-20184-2-0-4
  24. Рудых Н.А., Сиротина С.С. Генетические соотношения русских и украинских популяций Белгородской области. Научный результат. Медицина и фармация. 2015; 1(3): 72-79. doi: 10.18413/2313-8955-2015-1-3-72-79
  25. Сорокина И.Н., Рудых Н.А.,. Безменова И.Н., Полякова И.С. Популяционногенетические характеристики и генетико-эпидемиологическое исследование ассоциаций генов-кандидатов с мультифакториальными заболеваниями. Научные результаты биомедицинских исследований. 2018; 4 (4): 20-30. doi: 10.18413/2313-8955-2018-4-4-0-3
  26. Пономаренко И.В. Отбор полиморфных локусов для анализа ассоциаций при генетико-эпидемиологических исследованиях. Научный результат. Медицина и фармация. 2018;4(2):40-54. doi: 10.18413/2313-8955-2018-4-2-0-5
  27. Yotova I., Hsu E., Do C., Gaba A., Sczabolcs M., Dekan S. et al. Epigenetic alterations affecting transcription factors and signaling pathways in stromal cells of endometriosis. PLoS One. 2017; 12(1): e0170859. https://dx.doi.org/10.1371/journal.pone.0170859.
  28. Borghese B., Zondervan K.T., Abrao M.S., Chapron C., Vaiman D. Recent insights on the genetics and epigenetics of endometriosis. Clin. Genet. 2017; 91(2): 25464. https://dx.doi.org/10.1111/cge.12897.
  29. Nothnick W.B. Non-coding RNAs in uterine development, function and disease. Adv. Exp. Med. Biol. 2016; 886: 171-89. https://dx.doi.org/10.1007/978-94-017-7417-8_9.
  30. Nnoaham K.E., Webster P., Kumbang J., Kennedy S.H., Zondervan K.T. Is early age at menarche a risk factor for endometriosis? A systematic review and metaanalysis of case-control studies. Fertil. Steril. 2012; 98(3): 702-12. e6. https://dx.doi.org/10.1016/j.fertnstert.2012.05.035.
  31. Peterson C.M., Johnstone E.B., Hammoud A.O., Stanford J.B., Varner M.W., Kennedy A. et al. Risk factors associated with endometriosis: importance of study population for characterizing disease in the ENDO Study. Am. J. Obstet. Gynecol. 2013; 208(6): 451. e1-11. https://dx.doi.org/10.1016/j.ajog.2013.02.040.
  32. Ashrafi M., Sadatmahalleh S.J., Akhoond M.R., Talebi M. Evaluation of risk factors associated with endometriosis in infertile women. Int. J. Fertil. Steril. 2016; 10(1): 11-21.
  33. Wei M., Cheng Y., Bu H., Zhao Y., Zhao W. Length of menstrual cycle and risk of endometriosis: a meta-analysis of 11 case-control studies. Medicine (Baltimore). 2016; 95(9): e2922. https://dx.doi.org/10.1097/MD.0000000000002922.
  34. Parazzini F., Esposito G., Tozzi L., Noli S., Bianchi S. Epidemiology of endometriosis and its comorbidities. Eur. J. Obstet. Gynecol. Reprod. Biol. 2017; 209: 3-7. https://dx.doi.org/10.1016/j.ejogrb.2016.04.021.
  35. Parazzini F., Mais V., Cipriani S., Busacca M., Venturini P. Determinants of adenomyosis in women who underwent hysterectomy for benign gynecological conditions: results from a prospective multicentric study in Italy. Eur. J. Obstet. Gynecol. Reprod. Biol. 2009; 143(2): 103-6. https://dx.doi.org/10.1016/j.ejogrb.2008.12.010.
  36. Moini A., Malekzadeh F., Amirchaghmaghi E., Kashfi F., Akhoond M.R., Saei M. et al. Risk factors associated with endometriosis among infertile Iranian women. Arch. Med. Sci. 2013; 9(3): 506-14. https://dx.doi.org/10.5114/aoms.2013.35420.
  37. Buck Louis G.M., Hediger M.L., Pena J.B. Intrauterine exposures and risk of endometriosis. Hum. Reprod. 2007; 22(12): 3232-6. https://dx.doi.org/10.1093/humrep/dem338.
  38. Backonja U., Buck Louis G.M., Lauver D.R. Overall adiposity, adipose tissue distribution, and endometriosis: a systematic review. Nurs. Res. 2016; 65(2): 151-66. https://dx.doi.org/10.1097/NNR.0000000000000146.
  39. Yong L., Weiyuan Z. Association between body mass index and endometriosis risk: a meta-analysis. Oncotarget. 2017; 8(29): 46928-36. https://dx.doi.org/10.18632/oncotarget.14916.
  40. Vercellini P., Buggio L., Somigliana E., Barbara G., Vigano P., Fedele L. Attractiveness of women with rectovaginal endometriosis: a case-control study. Fertil. Steril. 2013; 99(1): 212-8. https://dx.doi.org/10.1016/j.fertnstert.2012.08.039.
  41. Sahmani M., Ghaleh T.D., Darabi M., Darabi M., Rashvand Z., Najafipour R. I405V polymorphism of CETP gene and lipid profile in women with endometriosis. Gynecol. Endocrinol. 2013; 29(7): 712-5. https://dx.doi.org/10.3109/09513590.2013.797396.
  42. Parazzini F., Vigano P., Candiani M., Fedele L. Diet and endometriosis risk: a literature review. Reprod. Biomed. Online. 2013; 26(4): 323-36. https://dx.doi.org/10.1016/j.rbmo.2012.12.011.
  43. Chiaffarino F., Bravi F., Cipriani S., Parazzini F., Ricci E., Vigano P. et al. Coffee and caffeine intake and risk of endometriosis: a meta-analysis. Eur. J. Nutr. 2014; 53(7): 1573-9. https://dx.doi.org/10.1007/s00394-014-0662-7.
  44. Parazzini F., Cipriani S., Bravi F., Pelucchi C., Chiaffarino F., Ricci E. et al. A metaanalysis on alcohol consumption and risk of endometriosis. Am. J. Obstet. Gynecol. 2013; 209(2): 106. e1-10. https://dx.doi.org/10.1016/j.ajog.2013.05.039

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies