Recurrences of uterine fibroids. The modern view on the problems of diagnosis, treatment, and prognosis


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The paper analyzes the data available in the literature on current methods for predicting and diagnosing uterine fibroids and identifies risk factors for disease recurrence. Further investigations of the pathogenetic features of recurrent uterine fibroids and development of new diagnostic criteria using non-invasive or minimally invasive methods will be able to predict possible recurrences and growth rates of fibroids.

Full Text

Restricted Access

About the authors

Narine M. Tonoyan

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health of Russian Federation

Email: tonnar.13@bk.ru
postgraduate student, Department of Operative Gynecology

Irena F. Kozachenko

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health of Russian Federation

PhD., senior researcher, Department of Operative Gynecology

Vladimir E. Frankevich

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health of Russian Federation

Email: v_frankevich@oparina4.ru
PhD, chief of the Department of Systems Biology in Reproduction

Vitaliy V. Chagovets

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health of Russian Federation

Email: vvchagovets@gmail.com
PhD, senior researcher, Laboratory of Proteomics and Metabolomics in Human Reproduction at the Department of Systems Biology in Reproduction

Leyla V. Adamyan

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Health of Russian Federation

Email: adamyanleila@gmail.com
MD, professor, head of the Department of Operative Gynecology

References

  1. Duhan N. Current and emerging treatments for uterine myoma - an update. Int. J. Women’s Health. 2011; 3: 231-41. http://dx.doi.org/10.2147/IJWH.S15710
  2. Donnez J., Tatarchuk T.F., Bouchard P., Puscasiu L., Zakharenko N.F., Ivanova T. et al. Ulipristal acetate versus placebo for fibroid treatment before surgery. N. Engl. J. Med. 2012; 366(5): 409-20. http://dx.doi.org/1056/NEJMoa1103182
  3. Bourdel N., Bonnefoy C., Jardon K., Da Ines D., Tognazza E., Rabischong B. et al. Myomectomie hystéroscopique: récidive et enquête de satisfaction à court et long terme. J. Gynecol. Obstet. Biol. Reprod. (Paris). 2011; 40(2): 116-22. http://dx.doi.org/10.1016/j.jgyn.2011.01.003
  4. Zimmermann A., Bernuit D., Gerlinger C., Schaefers M., Geppert K. Prevalence, symptoms and management of uterine fibroids: an international internet-based survey of 21,746 women. Womens Health. 2012; 12: 6.
  5. Тихомиров А.Л. Миома матки. Патогенетическое обоснование органосохраняющего лечения. Монография. М.; 2013.
  6. Адамян Л.В., Серов В.Н., Сухих Г.Т., Филиппов О.С., ред. Клинические рекомендации. Акушерство и гинекология Проблемы репродукции. 2015; 21(6, Спецвыпуск).
  7. Laganà A.S., Vergara D., Favilli A., La Rosa V.L., Tinelli A., Gerli S. et al. Epigenetic and genetic landscape of uterine leiomyomas: a current view over a common gynecological disease. Arch. Gynecol. Obstet. 2017; 296(5): 855-67. http://dx.doi.org/10.1007/s00404-017-4515-5
  8. Sparic R., Mirkovic L., Malvasi A., Tinelli A. Epidemiology of uterine myomas: a review. Int. J. Fertil. Steril. 2016; 9(4): 424-35.
  9. Ciavattini A., Di Giuseppe J., Stortoni P., Montik N., Giannubilo S.R., Litta P. et al. Uterine fibroids: pathogenesis and interactions with endometrium and endomyometrial junction. Obstet. Gynecol. Int. 2013; 2013; 173184. http://dx.doi.org/10.1155/2013/173184
  10. Mäkinen N., Mehine M., Tolvanen J., Kaasinen E., Li Y., Lehtonen H.J. et al. MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas. Science. 2011; 334(6053): 252-5.
  11. Chen Y.J., Li Y.T., Huang B.S., Yen M.S., Sheu B.C., Chow S.N. et al. Medical treatment for heavy menstrual bleeding. Taiwan. J. Obstet. Gynecol. 2015; 54: 483-8.
  12. Адамян Л.В. Состояние репродуктивной системы больных доброкачественными опухолями внутренних половых органов и принципы ее восстановления после хирургического лечения: дисс. д-ра мед. наук. М.; 1985.
  13. Donnez J., Donnez O., Dolmans M. With the advent of selective progesterone receptor modulators, what is the place of myoma surgery in current practice? Fertil. Steril. 2014; 102(3): 640-8.
  14. Поротикова И.Е., Адамян Л.В., Демура Т.А., Гаврилова Т.Ю., Доброхотова Ю.Э. Лейомиома тела матки у женщин репродуктивного возраста после ранее перенесенной эмболизации маточных артерий, фокусированной ультразвуковой абляции под контролем МРТ и миомэктомии: молекулярные, морфологические и клинические особенности. Проблемы репродукции. 2016; 22(2): 44-50. http://dx.doi.org/10.17116/repro201622244-50
  15. Вихляева Е.М., Паллади Г.А. Патогенез, клиника и лечение миомы матки. Кишинев: Штиинца; 1982.
  16. Поротикова И.Е., Адамян Л.В., Гаврилова Т.Ю., Демура Т.А., Козаченко И.Ф., Доброхотова Ю.Э., Асатурова А.В. Особенности хирургического лечения больных миомой матки после ранее перенесенной неэффективной эмболизации маточных артерий и ФУЗ-МРТ абляции. Проблемы репродукции. 2016; 22(3): 45-52. http://dx.doi.org/10.17116/repro201622345-52.
  17. Doridot V., Dubuisson J.B., Chapron C., Fauconnier A., Babaki-Fard K. Recurrence of leiomyomata after laparoscopic myomectomy. J. Am. Assoc. Gynecol. Laparosc. 2001; 8(4): 495-500.
  18. Караваев Ю.Е., Аскольская С.И., Коган Е.А. Прогностические критерии рецидива лейомиомы матки после реконструктивно-пластических операций. Акушерство и гинекология. 2013; 5: 54-7.
  19. Коган Е.А., Игнатова В.Е., Унанян А.Л., Сидорова И.С. Соотношение процессов пролиферации и апоптоза в разных гистологических типах лейомиомы матки. Архив патологии. 2005; 67(4): 32-6.
  20. Li M.H., Leng J.H., Shi J.H., Jia S.Z., Lang J.H. Comparison of postoperative residue, recurrence and pregnancy outcome between laparoscopic and transabdominal myomectomy. Zhonghua Fu Chan Ke Za Zhi. 2011; 46(9): 669-73.
  21. Hirschelmann A., De Wilde R.L. Plastic and reconstructive uterus operations by minimally invasive surgery? A review on myomectomy. GMS Interdiscip. Plast. Reconstr. Surg. DGPW. 2012; 1: Doc09. http://dx.doi.org/10.3205/iprs000009.
  22. Wen K.C., Sung P.L., Chang W.H., Horng H.C., Chen Y.J., Lee W.L., Wang P.H. A case-control study to compare the outcome of women treated by two minimally invasive procedures-ultraminilaparotomy myomectomy and laparoscopic myomectomy. Taiwan. J. Obstet. Gynecol. 2018; 57(2): 264-9. http://dx.doi.org/10.1016/j.tjog.2018.02.016
  23. Jacobson G.F., Shaber R.E., Armstrong M.A., Hung Y. Y. Changes in rates of hysterectomy and uterine conserving procedures for treatment of uterine leiomyoma. Am. J. Obstet. Gynecol. 2007; 196(6): 601. e1-5; discussion 601. e5-6. http://dx.doi.org/10.1016/j.ajong.2007.03.009
  24. Nishiyama S., Saito M., Sato K., Kurishita M., Itasaka T., Shioda K. High recurrence rate of uterine fibroids on transvaginal ultrasound after abdominal myomectomy in Japanese women. Gynecol. Obstet. Invest. 2006; 61(3): 155-9. http://dx.doi.org/10.1159/000090628
  25. Yoo E.H., Lee P.I., Huh C.Y., Kim D.H., Lee B.S., Lee J.K., Kim D. Predictors of leiomyoma recurrence after laparoscopic myomectomy. J. Minim. Invasive Gynecol. 2007; 14(6): 690-7.
  26. Rothmund R., Kurth R.R., Lukasinski N.M., Huebner M., Hartkopf A., Wallwiener M. et al. Clinical and pathological characteristics, pathological reevaluation and recurrence patterns of cellular leiomyomas: a retrospective study in 76 patients. Eur. J. Obstet. Gynecol. Reprod. Biol. 2013; 171(2): 358-61. http://dx.doi.org/10.1016/j.ejogrb.2013.10.004
  27. Shin D.G., Yoo H.J., Lee Y.A., Kwon I.S., Lee K.H. Recurrence factors and reproductive outcomes of laparoscopic myomectomy and minilaparotomic myomectomy for uterine leiomyomas. Obstet. Gynecol. Sci. 2017; 60(2): 193-9. http://dx.doi.org/10.5468/ogs.2017.60.2.193
  28. Вихляева Е.М., Ходжаева З.С., Фанченко Н.Д. Клинико-генеалогическое изучение наследственной предрасположенности к заболеванию миомой матки. Акушерство и гинекология. 1998; 2: 27-31. 1998.
  29. Адамян Л.В., Спицын В.А., Андреева Е.Н. Генетические аспекты гинекологических заболеваний. М.: Медицина; 1998.
  30. Celik et al., 2004, Podo F., Sardanelli F., Iorio E., Canese R., Carpinelli G., Fausto A. et al. Abnormal choline phospholipid metabolism in breast and ovary cancer: Molecular bases for noninvasive imaging approaches. Curr. Med. Imaging. Rev. 2007; 3: 123-37.
  31. Адамян Л.В., Караваев Ю.Е., Аскольская С.И. Состояние репродуктивной функции женщин после операции миомэктомии, выполненной разными доступами. В. кн.: Материалы XXIV Международного конгресса с курсом эндоскопии «Новые технологии в диагностике и лечении гинекологических заболеваний». М.; 2011: 66-7.
  32. Лисица А.В., Пономаренко Е.А., Лохов П.Г. Постгеномная медицина: альтернатива биомаркерам. Вестник Российской Академии медицинских наук. 2016; 3: 255-60.
  33. Писарев Д.И., Новиков О.О., Фадеева Д.А., Жилякова Е.Т., Казакова В.С., Писарева Н.А. Масс-спектрометрия: история и перспективы использования. Молодой ученый. 2012; 10: 99-104.
  34. Ding X., Wang L., Ren Y., Zheng W. Differences in mitochondrial proteins in the eutopic endometrium of patients with adenomyosis and endometriosis identified using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry. J. Int. Med. Res. 2010; 38(3): 987-93.
  35. De Petris L., Pernemalm M., Elmberger G., Bergman P., Orre L., Lewensohn R., Lehtiö J. A novel method for sample preparation of fresh lung cancer tissue for proteomics analysis by tumor cell enrichment and removal of blood contaminants. Proteome Sci. 2010; 8: 9.
  36. Pourfarzam M., Zadhoush F. Newborn Screening for inherited metabolic disorders; news and views. J. Res. Med. Sci. 2013; 18(9): 801-8.
  37. Mischak H. Urine proteomics as a liquid kidney biopsy: no more kidney punctures. Nephrol. Dial. Transplant. 2015; 30(4): 532-7.
  38. Buhimschi I.A., Nayeri U.A., Zhao G., Shook L.L., Pensalfini A., Funai E.F. et al. Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia. Sci. Transl. Med. 2014; 6(245): 245ra92.
  39. Meng Q.H. Mass spectrometry applications in clinical diagnostics. J. Clin. Exp. Pathol. 2013; 1(Suppl. 6): e001.
  40. Wang H., Manicke N.E., Yang Q., Zheng L., Shi R., Cooks R.G., Ouyang Z. Direct analysis of biological tissue by paper spray mass spectrometry. Anal. Chem. 2011; 83(4): 1197-201.
  41. Pietrowska M., Marczak L., Polanska J., Behrendt K., Nowicka E., Walaszczyk A. et al. Mass spectrometry-based serum proteome pattern analysis in molecular diagnostics of early stage breast cancer. J. Transl. Med. 2009; 7: 60.
  42. Боpисова А.В., Чаговец В.В., Козаченко А.В., Стаpодубцeва Н.Л., Кононихин А.С., Салимова Д.Ф., Коган Е.А., Адамян Л.В., Франкевич В.Е., Сухих Г.Т. Сравнительный анализ липидного состава перитонеальной жидкости и плазмы крови у пациенток с наружным генитальным эндометриозом и миомой матки. Акушерство и гинекология. 2017; 6: 74-82. http://dx.doi.org/10.18565/aig.2017.6.74-82
  43. Balog J., Szaniszlo T., Schaefer K.C., Denes J., Lopata A., Godorhazy L. et al. Identification of biological tissues by rapid evaporative ionization mass spectrometry. Anal Chem. 2010; 82(17): 7343-50.
  44. Zhang W., Wang X., Xia Y., Ouyang Z. Ambient ionization and miniature mass spectrometry systems for disease diagnosis and therapeutic monitoring. Theranostics. 2017; 7: 2968-81.
  45. Cooks R.G., Manicke N.E., Dill A.L., Ifa L.S., Costa A.B., Wang H. et al. New ionization methods and miniature mass spectrometers for biomedicine: DESI imaging for cancer diagnostics and paper spray ionization for therapeutic drug monitoring. Faraday Discuss. 2011; 149: 247-67.
  46. Guenther S., Muirhead L.J., Speller A.V., Golf O., Strittmatter N., Ramakrishnan R. et al. Spatially resolved metabolic phenotyping of breast cancer by desorption electrospray ionization mass spectrometry. Cancer Res. 2015; 75(9): 1828-37.
  47. Ashizawa K., Yoshimura K., Johno H., Inoue T., Katoh R., Funayama S. et al. Construction of mass spectra database and diagnosis algorithm for head and neck squamous cell carcinoma. Oral Oncol. 2017; 75: 111-9. http://dx.doi.org/10.1016/j.oraloncology.2017.11.008
  48. Kerian K.S., Jarmusch A.K., Cooks R.G. Touch spray mass spectrometry for in situ analysis of complex samples. Analyst. 2014; 139(11): 2714-20.
  49. Kerian K.S., Jarmusch A.K., Pirro V., Koch M.O., Masterson T.A., Cheng L., Cooks R.G. Differentiation of prostate cancer from normal tissue in radical prostatectomy specimens by desorption electrospray ionization and touch spray ionization mass spectrometry. Analyst. 2015; 140(4): 1090-8.
  50. St John E.R., Balog J., McKenzie J.S., Rossi M., Covington A., Muirhead L. et al. Rapid evaporative ionisation mass spectrometry of electrosurgical vapours for the identification of breast pathology: towards an intelligent knife for breast cancer surgery. Breast Cancer Res. 2017; 19(1): 59. http://dx.doi.org/10.1186/s13058-017-0845-2
  51. Jamaluddin M.F.B., Nagendra P.B., Nahar P., Oldmeadow C., Tanwar P.S. Proteomic analysis identifies tenascin-C expression is upregulated in uterine fibroids. Reprod. Sci. 2018; 26(4): 476-86. http://dx.doi.org/10.1177/1933719118773420
  52. Heinonen H.R., Mehine M., Mäkinen N., Pasanen A., Pitkänen E., Karhu A. et al. Global metabolomic profiling of uterine Leiomyomas. Br. J. Cancer. 2017; 117(12): 1855-64. http://dx.doi.org/10.1038/bjc.2017.361
  53. Heinonen H.R., Pasanen A., Heikinheimo O., Tanskanen T., Palin K., Tolvanen J. et al. Multiple clinical characteristics separate MED12-mutation-positive and -negative uterine leiomyomas. Sci. Rep. 2017; 7: 1015.

Supplementary files

Supplementary Files
Action
1. JATS XML

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies