Free amino acid imbalances in amniotic fluid in preeclampsia


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Abstract

Subjects and methods. The investigation enrolled 34 women, whose pregnancy was complicated with PE (a study group) and 30 women with uncomplicated pregnancy (a control group). The levels of amino acids in the amniotic fluid were determined in the second and third trimesters of pregnancy, by using an automated amino acid analyzer. Results. PE was found to develop in the presence of multidirectional changes in the content of amino acids involved in many metabolic processes required for normal fetoplacental function. Different trimesters of pregnancy differ in the magnitude of the deviations found in the composition of amino acids in the amniotic fluid. The most pronounced imbalance was observed in the second trimester. The possibility of damage to different metabolic pathways in the second and third trimesters is discussed. Conclusion. The findings make it possible to expand our understanding of the biochemical mechanisms of the formation and development of PE and to elaborate criteria for predicting this pathology.

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About the authors

Tatiana N. Pogorelova

Rostov State Medical University, Ministry of Health of Russia

Email: tnp.rniiap@yandex.ru
Doctor of Biological Science, professor, chief researcher, Scientific-Research Institute of Obstetrics and Pediatrics

Victorya O. Gunko

Rostov State Medical University, Ministry of Health of Russia

Email: rniiap@yandex.ru
PhD, senior researcher, Scientific-Research Institute of Obstetrics and Pediatrics

Natalya Viktorovna Palieva

Rostov State Medical University, Ministry of Health of Russia

Email: nat-palieva@yandex.ru
MD, chief researcher, Scientific-Research Institute of Obstetrics and Pediatrics

Ilya A. Alliluev

Rostov State Medical University, Ministry of Health of Russia; Southern Federal University

junior researcher of Scientific-Research Institute of Obstetrics and Pediatrics

Lyudmila V. Kaushanskaya

Rostov State Medical University, Ministry of Health of Russia

Email: kaushan60@mail.ru
chief researcher, Scientific-Research Institute of Obstetrics and Pediatrics

Andrej V. Larichkin

Rostov State Medical University, Ministry of Health of Russia

Email: rniiap@yandex.ru
junior researcher, Scientific-Research Institute of Obstetrics and Pediatrics

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