Peripheral blood cytokine levels in women according to the phase of the first period of labor


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Objective. To study peripheral blood cytokine levels in primiparous women according to the phase of the first period of labor. Subjects and methods. Peripheral blood samples were collected from 38 primiparous women in the latent and active phases of labor. Serum cytokine levels were determined using the standard Bio-Plex Pro Human Cytokine 17-plex Assay (Bio-Rad, USA). Results. The active phase of labor was found to be characterized by increased IL-6 levels and decreased TNF-α, IFN-γ, IL-12, IL-4, and IL-13. Conclusion. Cytokine balance is important in the dynamics of delivery and in the mechanisms of its abnormal development.

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作者简介

Oleg Tysyachnyy

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia

Email: olti23@mail.ru
PhD., junior scientific researcher of the first maternity departments

Olga Pavlova

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia

Email: olgandrevna@mail.ru
postgraduate student of the first maternity departments

Valentina Vtorushina

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia

Email: vtorushina@inbox.ru
PhD, doctor of the highest category of the Clinical Immunology

Lyubov Krechetova

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia

Email: l_krechetova@oparina4.ru
PhD, head of the Clinical Immunology Laboratory

Oleg Baev

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

Email: metod_obsgyn@hotmail.com
MD, professor, head of the first Maternity Department; Department of Obstetrics, Gynecology, Perinatology and Reproduction.

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