The features of clinical course and complexities in the diagnosis of a case of epithelioid trophoblastic disease


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Abstract

Background. Epithelioid trophoblastic tumor was first described by morphologists in 1995; the world literature reports only about 90 cases of this tumor, which confirms its extreme rarity. This type of tumor is characterized by high malignancy and fairly rapid distant metastasis. At the same time, the current chemotherapy regimens, even those for distant metastases, show a good sufficient efficiency. Clinical case report. The paper analyzes the features of clinical course, diagnostic difficulties, and the observation in epithelioid tumor. It presents difficulties in the interpretation of clinical data and in the differential diagnosis of morphological features in this type of tumor. The authors show the expediency and high informative value of immunohistochemical examination of a tissue specimen. Conclusion. This category of patients should be examined and treated in specialized clinics that have a possibility to perform combined treatment and positive experiences in treating patients with trophoblastic tumors.

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About the authors

Alyona L. Chernyshova

Research Institute of Oncology, Tomsk National Research Medical Center

Email: alacher@list.ru
MD, professor of RAS, leading researcher, Gynecology Department, Cancer Research Institute

Larisa A. Kolomiets

Research Institute of Oncology, Tomsk National Research Medical Center

Email: kolomietsla@oncology.ru
MD, professor, head of Gynecology Department, Cancer Research Institute

Anastasia Yu. Kishkina

Research Institute of Oncology, Tomsk National Research Medical Center

postgraduate, Gynecology Department, Cancer Research Institute

Maxim O. Ochirov

Research Institute of Oncology, Tomsk National Research Medical Center

postgraduate, Gynecology Department, Cancer Research Institute

Svetlana A. Glushchenko

Research Institute of Oncology, Tomsk National Research Medical Center

PhD, doctor of the Department of Pathomorphology, Cancer Research Institute

Vladimir M. Perelmuter

Research Institute of Oncology, Tomsk National Research Medical Center

Email: perelmuter@oncology.ru
MD, professor, head of the Department of Pathomorphology, Cancer Research Institute

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