The role of NOD1 and NOD2 receptors in recognizing pathogens in the female reproductive tract


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Abstract

NOD1 and NOD2 receptors belong to the NOD-like receptor (NLR) family. They are cellular cytosolic innate immune receptors that recognize the components of bacterial peptidoglycan and viral RNA. NOD1 and NOD2 are expressed in all organs of the female reproductive tract, with their maximum expression observed in the fallopian tubes. The endometrial expression of NOD1 mRNA does not depend on the phase of the menstrual cycle, while the expression of NOD2 is maximal in the late secretory phase. NOD1 and NOD2 are able to recognize a number of opportunistic and pathogenic bacteria, viruses, and protozoa. Some microorganisms (Listeria monocytogenes, Neisseria gonorrhoeae) have mechanisms to avoid recognition, which ensures their long-term intracellular persistence.

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About the authors

Olga P. Lebedeva

Belgorod State National Research University; Voronezh State University

Email: safonova2@yandex.ru
MD, associate professor, professor of the Department of Obstetrics and Gynaecolgy; senior researcher of the Department of Genetics, Cytology and Bioengineering

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