Gestational diabetes mellitus and obstetric complications


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Abstract

Gestational diabetes mellitus is not only an important medical, but also a serious social problem in developed countries. Despite the sufficiently high level of development of modern medicine, the prevalence of gestational diabetes mellitus is gradually increasing and reflects an increase in the incidence of obesity and type 2 diabetes mellitus worldwide. The specialized literature has been reviewed to analyze the main issues of the etiopathogenesis and diagnosis of gestational diabetes mellitus. The paper analyzes the data of Russian and foreign studies of the causes and risk factors of gestational diabetes mellitus. The presented materials demonstrate that gestational diabetes mellitus is associated with several maternal and fetal comorbidities in the short term and carries a high risk of type 2 diabetes and cardiovascular diseases for both mother and child in the future in the long term. In this connection, a search for universal markers is needed to identify women at high risk of gestational diabetes mellitus.

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About the authors

Elena Y. Zagarskikh

Maternity Hospital Ten, Saint Petersburg

Email: zagarsklena@mail.ru
MD, professor, endocrinologist

Nadezhda A. Kurashova

Research Center for Family Health and Human Reproduction Problems

Email: nakurashova@yandex.ru
MD, researcher of the Laboratory of Pathophysiology

References

  1. Hajifaraji M., Jahanjou F., Abbasalizadeh F., Aghamohammadzadeh N., Abbasi M.M., Dolatkhah N. Effect of probiotic supplements in women with gestational diabetes mellituson inflammation and oxidative stress biomarkers: a randomized clinical trial. Asia Pac. J. Clin. Nutr. 2018; 27(3): 581-91. https://dx.doi. org/10.6133/apjcn.082017.03.
  2. Moyer V.A.; U.S. Preventive Services Task Force. Screening for gestational diabetes mellitus: U.S. Preventive Services Task Force recommendation statement. Ann. Intern. Med. 2014; 160(6): 414-20. https://dx.doi.org/10.7326/M13-2905.
  3. Peng T.Y., Ehrlich S.F., Crites Y., Kitzmiller J.L., Kuzniewicz M.W., Hedderson M.M., Ferrara A. Trends and racial and ethnic disparities in the prevalence of pregestational type 1 and type 2 diabetes in Northern California: 1996-2014. Am. J. Obstet. Gynecol. 2017; 216(2): 177. e1-177. e8. https://dx.doi. org/10.1016/j.ajog.2016.10.007.
  4. Hagiwara Y., Kasai J., Nakanishi S., Saigusa Y., Miyagi E., Aoki S. Should the IADPSG criteria be applied when diagnosing early-onset gestational diabetes? Diabetes Res. Clin. Pract. 2018; 140: 154-61. https://dx.doi.org/10.1016/j. diabres.2018.03.048.
  5. American Diabetes Association. Position statement: diagnosis and classification of diabetes mellitus. Diabetes Care. 2010; 33(1): 62-9.
  6. Дедов И.И., Мельниченко Г.А., ред. Эндокринология. Национальное руководство. М.: ГЭОТАР-Медиа; 2008. 1072c.
  7. Flack J.R., Ross G.P. Survey on testing for gestational diabetes mellitus in Australia. Aust. N. Z. J. Obstet. Gynaecol. 2016; 56(4): 346-8. https://dx.doi. org/10.1111/ajo.12457.
  8. Wu E.T., Nien F.J., Kuo C.H., Chen S.C., Chen K.Y., Chuang L.M. et al. Diagnosis of more gestational diabetes lead to better pregnancy out comes: Comparing the International Association of the Diabetes and Pregnancy Study Group criteria, and the Carpenter and Coustan criteria. J. Diabetes Investig. 2016; 7(1): 121-6. https://dx.doi.org/10.1111/jdi.12378.
  9. Lavery J.A., Friedman A.M., Keyes K.M., Wright J.D., Ananth C.V. Gestational diabetes in the United States: temporal changes in prevalence rates between 1979 and 2010. BJOG. 2017; 124(5): 804-13.
  10. Zaman F., Nouhjah S., Shahbazian H., Shahbazian N., Latifi.M., Jahanshahi A. Risk factors ofgestational diabetes mellitususing results of a prospective population-based study in Iranian pregnant women. Diabetes Metab. Syndr. 2018; 12(5): 721-5. https://dx.doi.org/10. 1016/j.dsx.2018.04.014.
  11. Xiao Y., Chen R., Chen M., Luo A., Chen D., Liang Q. et al. Age at menarche and risks ofgestational diabetes mellitus: a meta-analysis of prospective studies. Oncotarget. 2017; 9(24): 17133-40. https://dx.doi.org/10.18632/oncotar-get.23658.
  12. Lizneva D., Suturina L., Walker W., Brakta S., Gavrilova-Jordan L., Azziz R. Criteria, prevalence and phenotypes of polycystic ovary syndrome. Fertil. Steril. 2016; 106(1): 6-15.
  13. Buckley B.S., Harreiter J., Damm P., Corcoy R., Chico A., Simmons D. et al. Gestational diabetes mellitus in Europe: prevalence, current screening practice and barriers to screening. A review. Diabet. Med. 2012; 29(7): 844-54.
  14. Mc Guane J.T., Grlj L., Peek M.J. Obesity, gestational diabetes and macrosomia are associated with increasing rates of early-term induction of labour at The Canberra Hospital. Aust. N. Z. J. Obstet. Gynaecol. 2019; 59(2): 215-20. https:// dx.doi.org/10.1111/ajo.12820.
  15. Lima R.J.C.P., Batista R.F.L., Ribeiro M.R.C., Ribeiro C.C.C., Simoes V.M.F., Lima Neto P.M. et al. Prepregnancy body mass index, gestational weight gain, and birth weight in the BRISA cohort. Rev. Saude Publica. 2018; 52: 46. https:// dx.doi.org/10.11606/s1518-8787.2018052000125.
  16. International Weight Management in Pregnancy (i-WIP) Collaborative Group. Effect of diet and physical activity based interventions in pregnancy on gestational weight gain and pregnancy outcomes: meta-analysis of individual participant data from randomised trials. BMJ. 2017; 358: j3119. https://dx.doi. org/10.1136/bmj.j3119.
  17. Meinila J., Valkama A., Koivusalo S.B., Rono K., Kautiainen H., Lindstrom J. et al. Association between diet quality measured by the Healthy Food Intake Index and later risk of gestational diabetes-a secondary analysis of the RADIEL trial. Eur. J. Clin. Nutr. 2017; 71(7): 913. https://dx.doi.org/10.1038/ejcn.2017.66
  18. Valkama A.J., Meinila J., Koivusalo S., Lindstrom J., Rono K., Stach-Lempinen B. et al. The effect of pre-pregnancy lifestyle counselling on food intakes and association between food intakes and gestational diabetes in high-risk women: results from a randomised controlled trial. J. Hum. Nutr. Diet. 2018; 31(3): 301 35. https://dx.doi.org/10.1111/jhn.12547
  19. Michalakis K., Mintziori G., Kaprara A., Tarlatzis B.C., Goulis D.G. The complex in teraction between obesity, metabolic syndrome and reproductive axis: Anarrative review. Metabolism. 2013; 62(4): 457-78. https://dx.doi. org/10.1016/j.metabol.2012.08.012.
  20. Петунина Н.А., Кузина И.А. Роль гормонов жировой ткани в развитии осложнений беременности у женщин с ожирением. Ожирение и метаболизм. 2013; 10(1): 3-8. [Petunina N.A., Kuzina I.A. The role of adipose tissue hormones in the development of pregnancy complications in obese women. Obesity and metabolism. 2013; 10 (1): 3-8. (in Russian)]. https://dx.doi. org/10.14341/2071-8713-2013-1.
  21. Lobo T.F., Torloni M.R., Mattar R., Nakamura M.U., Alexandre S.M., Daher S. Adipokine levels in overweight women with early-onset gestational diabetes mellitus. J. Endocrinol. Invest. 2019; 42(2): 149-56. https://dx.doi.org/10.1007/ s40618-018-0894-0.
  22. Nanda S., Yu C.K.H., Giurcaneanu L., Akolekar R., Nicolaides K.H. Maternal serum adiponectin at 11-13 weeks of gestation in preeclampsia. Fetal Diagn. Ther. 2011; 29(3): 208-15. https://dx.doi.org/10.1159/000322402.
  23. Kelly C.B., Hookham M.B., Yu J.Y., Lockhart S.M., Du M., Jenkins A.J. et al. Circulating adipokines are associated with pre-eclampsia in women with type 1 diabetes. Diabetologia. 2017; 60(12): 2514-24. https://dx.doi.org/10.1007/ s00125-017-4415-z.
  24. Mao J., Bath S.C., Vanderlelie J.J., Perkins A.V., Redman C.W., Rayman M.P. No effect of modest selenium supplementation on insulin resistance in UK pregnant women, as assessed by plasma adiponectin concentration. Br. J. Nutr. 2016; 115(1): 32-8. https://dx.doi.org/10.1017/S0007114515004067.
  25. Xiao L., Zhao J.P., Nuyt A.M., Fraser W.D., Luo Z.C. Female fetus is associated with greater maternal insulin resistance in pregnancy. Diabet. Med. 2014; 31(12): 1696-701. https://dx.doi.org/10.1111/dme.12562.
  26. Li S., Yang H. Relationship between advanced glycation end products and gestational diabetes mellitus. J. Matern. Fetal Neonatal Med. 2018; Mar 21: 1-7. https://dx.doi.org/10.1080/14767058.2018.1449201.
  27. Despres J.P., Lemieux I., Bergeron J., Pibarot P., Mathieu P., Larose E. et al. Abdominal obesity and the metabolic syndrome: contribution to global cardio-metabolic risk. Arterioscler. Thromb. Vasc. Biol. 2008; 28(6): 1039-49. https:// dx.doi.org/10.1161/atvbaha.107.159228.
  28. Timur B.B., Timur H., Tokmak A., Isik H., EyiE.G.Y. The influence of maternal obesity on pregnancy complications and neonatal outcomes in diabetic and nondiabetic women. Geburtshilfe Frauenheilkd. 2018; 78(4): 400-6. https://dx.doi. org/10.1055/a-0589-2833.
  29. Cade W.T., Levy P.T., Tinius R.A., Patel M.D., Choudhry S., Holland M.R. et al. Markers of maternal and infant metabolism are associated with ventricular dysfunction in infants of obese women with type 2 diabetes. Pediatr. Res. 2017; 82(5): 768-75. https://dx.doi.org/10.1038/pr.2017.140.
  30. Shang M., Dong X., Hou L. Correlation of adipokines and markers of oxidative stress in women with gestational diabetes mellitus and their newborns. J. Obstet. Gynaecol. Res. 2018; 44(4): 637-46. https://dx.doi.org/10.1111/ jog.13586.
  31. Jamaluddin M.S., Weakley S.M., Yao Q., Chen C. Resistin: functional roles and therapeutic considerations for cardiovascular disease. Br. J. Pharmacol. 2012; 165(3): 622-32. https://dx.doi.org/10.1111/j.1476-5381.2011.01369.x.
  32. Han Y., Zheng Y.L., Fan Y.P., Liu M.H., Lu X.Y., Tao Q. Association of adipo-nectin gene polymorphism 45TG with gestational diabetes mellitusdiagnosed on the new IADPSG criteria, plasma adiponectin levels and adverse pregnan-cyoutcomes. Clin. Exp. Med. 2015; 15(1): 47-53. https://dx.doi.org/10.1007/ s10238-014-0275-8.
  33. Tal R., Seifer D.B., Arici A. The emerging role of angiogenic factor dysregulation in the pathogenesis of polycystic ovarian syndrome. Semin. Reprod. 2015; 33: 195-207.
  34. Gobl C.S., Bozkurt L., Yarragudi R., Prikoszovich T., Tura A., Pacini G. et al. Biomarkers of endothelial dysfunction in relation to impaired carbohydrate metabolism following pregnancy with gestational diabetes mellitus. Cardiovasc. Diabetol. 2014; 13: 138. https://dx.doi.org/10.1186/s12933-014-0138-3.
  35. Mordwinkin N.M., Ouzounian J.G., Yedigarova L., Montoro M.N., Louie S.G., Rodgers K.E. Alteration of endothelial function markers in women with gestational diabetes and their fetuses. J. Matern. Fetal Neonatal Med. 2013; 26(5): 507-12. https://dx.doi.org/10.3109/14767058.2012.736564.
  36. International Association of Diabetes and Pregnancy Study Groups. International Association of Diabetes and Pregnancy Study Groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care. 2010; 33(3): 676-82.
  37. Parlea L., Bromberg I.L., Feig D.S., Vieth R., Merman E., Lipscombe L.L. Association between serum 25-hydroxyvitamin D. in early pregnancy and risk of gestational diabetes mellitus. Diabet. Med. 2012; 29(7): e25-32. https:// dx.doi.org/10.1111/j.1464-5491.2011.03550.x
  38. Колесникова Л.И., Осипова Е.В., Гребенкина Л.А. Окислительный стресс при репродуктивных нарушениях эндокринного генеза у женщин. Новосибирск; 2011. 116с.
  39. Fruscalzo A., Londero A.P., Driul L., Henze A., Tonutti L., Ceraudo M. et al. First trimester concentrations of the TTR-RBP4-retinol complex components as early markers of insulin-treated gestational diabetes mellitus. Clin. Chem. Lab. Med. 2015; 53(10): 1643-51. https://dx.doi.org/10.1515/cclm-2014-0929.
  40. Metcalfe A., Sabr Y., Hutcheon J.A., Donovan L., Lyons J., Burrows J., Joseph K.S. Trends in obstetric intervention and pregnancy outcomes of Canadian women with diabetes in pregnancy from 2004 to 2015. J. Endocr. Soc. 2017; 1(12): 1540 9. https://dx.doi.org/10.1210/js.2017-00376
  41. Li X., Zhang W., Lin J., Liu H., Yang Z., Teng Y. et al. Risk factors for adverse maternal and perinatal outcomes in women with preeclampsia: analysis of 1396 cases. J. Clin. Hypertens. (Greenwich). 2018; 20(6): 1049-57. https://dx.doi. org/10.1111/jch.13302.
  42. Baliutaviciene D., Buinauskiene J.B., Petrenko V., Danyte E., Zalinkevicius R. Gestational diabetes, obesity, and metabolic syndrome diagnosed during pregnancy. Metab. Syndr. Relat. Disord. 2012; 10(3): 214-7. https://dx.doi. org/10.1089/met.2011.0067.
  43. Sacks D.A. The use of pharmacotherapy in pregnancies with suspected diabetic fetopathy. J. Matern. Fetal Neonatal Med. 2012; 25(1): 45-9. https://dx.doi.org/ 10.3109/14767058.2012.626929.
  44. Desoye G., Nolan C.J. The fetal glucose steal: an underappreciated phenomenon in diabetic pregnancy. Diabetologia. 2016; 59(6): 1089-94. 10.1007/s00125-016-3931-6.
  45. Esakoff T.F., Cheng Y.W., Sparks T.N., Caughey A.B. The association between birthweight 4000 g or greater and perinatal outcomes in patients with and without gestational diabetes mellitus. Am. J. Obstet. Gynecol. 2009; 200(6): 672. e671-672. e674. https://dx.doi.org/10.1016/j.ajog.2009.02.035.
  46. Li J., Qian G., Zhong X., Yu T. Insulin treatment cannot promote lipogenesis in rat fetal lung in gestational diabetes mellitus because of failure to redress the imbalance among SREBP-1, SCAP, and INSIG-1. DNA Cell Biol. 2018; 37(3): 264-70. https://dx.doi.org/10.1089/dna.2017.3906.
  47. Чабанова Н.Б., Матаев С.И., Василькова Т.Н., Трошина И. А. Метаболические нарушения при адипоцитокиновом дисбалансе и гестационные осложнения. Ожирение и метаболизм. 2017; 14(1): 9-16. [Chabanova N.B., Mataev S.I., Vasilkova T.N., Troshina I.A. Metabolic disorders in adipocytokine imbalance and gestational complications. Obesity and metabolism. 2017; 14 (1): 9-16. (in Russian)]. https://dx.doi.org/10.14341/ OMET201719-16.
  48. Agarwal M.M., Punnose J., Sukhija K., Sharma A., Choudhary NK. Gestational diabetes mellitus: using the fasting plasma glucose level to simplify the International Association of Diabetes and Pregnancy Study Groups Diagnostic Algorithm in an Adult South Asian Population. Can. J. Diabetes. 2018; 42(5): 500-4. https://dx.doi.org/10.1016/j.jcjd.2017.12.009.

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