Late pregnancy termination by a medical technique in combination with cervical osmotic dilators


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Abstract

Objective. To analyze the effectiveness of late pregnancy termination by mifepristone/misoprostol in combination with Dilapan-S cervical osmotic dilators. Materials and methods. The publications available in the Cochrane and PubMed databases, as well as the guidelines of international and Russian professional communities and the clinical trials published in the public domain were analyzed. Results. The review presents scientific data suggesting that Dilapan-S osmotic dilators in the simultaneous use of mifepristone and misoprostol can achieve cervical dilation, induction of uterine contractility, and pregnancy termination in a shorter time (within one day) than mifepristone/misoprostol only. The use of Dilapan-S is shown to be more preferable than that of Laminaria in the medical pregnancy termination protocols. Conclusion. The most optimal procedures for cervical preparation have not yet been determined and further investigations are needed to work out clearer recommendations for specific clinical situations.

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About the authors

Victor L. Tyutyunnik

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: tioutiounnik@mail.ru
MD, professor, the head of the Obstetric Physiological Department

Galina B. Dikke

Academy of Medical Education named F.I. Inozemtsev

Email: galadikke@yandex.ru
MD, professor of the Department of Obstetrics and Gynecology with a course of reproductive medicine

Natalia E. Kan

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: kan-med@mail.ru
MD, professor, Department of Obstetrics and Gynecology

Zuhra Kh. Uzdenova

Kh.M. Berbekov Kabardino-Balkar State University

Email: elifiya@bk.ru
MD, professor of the Department of Pediatric Diseases, Obstetrics and Gynecology, honored doctor of the Kabardino-Balkarian Republic

Evgenia Yu. Shcherbatykh

OOO "Umnaya Meditsina" (Smart Medicine)

Email: skvoshechka@mail.ru
PhD, medical center «Smart Medicine», obstetrician-gynecologist.

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