Metric analysis of comorbidity ratios between miscarriage, endometriosis, menstrual disorders, and micronutrient provision in screening reproductive-aged women


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Abstract

Objective. To evaluate relationships between micronutrient provision and a history of recurrent miscarriage, endometriosis, and menstrual disorders. Subjects and methods. Metric methods for big data analysis were used to examine a clinically homogeneous sample of623 women aged 18-35years (3,922 indicators). Results. The investigators revealed complex interactions were established between miscarriage, anamnestic and biochemical indicators, and inadequate intake of vitamins, macro- and micronutrients, including those as components of vitamin-mineral complexes (VMCs). lower intake of vitamins D, A, E, B-group, and folate, potassium, magnesium, calcium, omega-3 polyunsaturated fatty acids (PUFA) and the trace elements Fe, Zn, Cu, Mn, and Se was established for patients with miscarriage. Their inadequate intake was confirmed by blood micronutrient marker testing. Conclusion. The intake of special VMCs among reproductive-aged women is an important resource for the prevention of miscarriage, endometriosis, and menstrual disorders.

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About the authors

Ivan Yu. Torshin

Institute of Pharmacoinformatics

PhD in Applied Mathematics

Olga A. Gromova

Federal Research Center «Computer Science and Control» of Russian Academy of Sciences

Email: unesco.gromova@gmail.com
MD, professor, science head of the Institute of Pharmacoinformatics, leading researcher of the Department of Intellectual Systems FRCCSC RAS

Nana K. Tetruashvili

Email: n_tetruashvili@oparina4.ru
MD, head of the Department of Pregnancy Loss Prevention and Therapy

Vera M. Kodentsova

FGBUN «FITS Nutrition and Biotechnology»

Doctor of Biological Sciences, professor, senior researcher, Laboratory of Vitamins and Microelements

Anna N. Galustyan

St. Petersburg State Pediatric University

Email: klinika.spb@gmail.com
PhD, associate professor, head of the Department of Pharmacology with the course of clinical pharmacology and pharmacoeconomics

Natalia A. Kuritsyna

Federal State budgetary Educational Institution of Higher Education «St. Petersburg State Pediatric Medical University» of the Ministry of Health of the Russian Federation

Email: klinika.spb@gmail.com
associate professor of the Department of Pharmacology with a course of clinical pharmacology and pharmacoeconomics

Nikanor V. Lavrov

Federal State budgetary Educational Institution of Higher Education «St. Petersburg State Pediatric Medical University» of the Ministry of Health of the Russian Federation

Email: nikanlavr@rambler.ru
associate professor of the Department of Pharmacology with a course of clinical pharmacology and pharmacoeconomics

Tatiana R. Grishina

Ivanovo State Medical Academy

head of the Department of Pharmacology

Olga A. Limanova

FSBEI HE IvGMA of the Ministry of Health of the Russian Federation

Email: unesco.gromova@gmail.com
PhD, associate professor of the Department of Pharmacology

Alla G. Kalacheva

State Budgetary Educational Institution of Higher Professional Education IvGMA Ministry of Social Development and Health of the Russian Federation

PhD, associate professor of the Department of Pharmacology and Clinical Pharmacology

Lyubov E. Fedotova

State Budgetary Educational Institution of Higher Professional Education IvGMA Ministry of Social Development and Health of the Russian Federation

Email: unesco.gromova@gmail.com
PhD, associate professor of the Department of Pharmacology and Clinical Pharmacology

Nina P. Lapochkina

Ivanovo State Medical Academy

MD, Department of Oncology, Obstetrics and Gynecology.

Nadezhda V. Kerimkulova

Ivanovo State Medical Academy

associate professor of the Department of Oncology, Obstetrics and Gynecology

Elena V. Mozgovaya

«D.O. Ott Research Institute of Obstetrics»

Email: elmozg@mail.ru
PhD, associate professor, D.O. Doctor of Medical Sciences, associate professor, head of the Obstetric Department with Perinatology

Natalia I. Tapilskaya

«D.O. Ott Research Institute of Obstetrics»

Email: tapnatalia@yandex.ru
MD, professor, leading researcher of the Department of Assisted Reproductive Technologies

Vladimir A. Semenov

Kemerovo State Medical University

Email: semenov_v_a.7l7@mail.ru
MD, professor

Svetlana I. Malyavskaya

FGBOU VO SevGMU of the Ministry of Health of Russia; Federal State Budget Educational Institution of Higher Education «Northern State Medical University» of the Ministry of Health of the Russian Federation

Email: nauka@nsmu.ru
MD, professor, head of sciences

Andrey V. Lebedev

Federal State Budget Educational Institution of Higher Education «Northern State Medical University» of the Ministry of Health of the Russian Federation

Email: nauka@nsmu.ru

Darya E. Frolova

Ivanovo State Medical Academy

Email: Frolova.D37@yandex.ru
assistant of the Department of Oncology, Obstetrics and Gynecology

Anna N. Rubashkina

Federal State Budgetary Educational Institution of Higher Education «Ivanovo State Medical Academy» of the Ministry of Health of the Russian Federation

gynecologist, Department of Oncology, Obstetrics and Gynecology

Konstantin V. Rudakov

Federal Research Center for Informatics and Management RAS; MIPT

academician of the Russian Academy of Sciences, Scientific Director; head of the Department of Intellectual Systems

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