Interleukin-10 production and secretion in blood in relation to interleukin-10 A-1082G polymorphism in pregnant women with fetal growth restriction


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Abstract

Objective. To clarify risk factors for fetal growth restriction (FGR), to determine the features of a genotype by the interleukin (IL)-10 A-1082G polymorphism and its effect on the production and secretion of IL-10 by peripheral blood monocytes in women with FGR. Subjects and methods. A total of209pregnant women were surveyed. The investigators assessed IL-10A-1082G gene polymorphism by a real-time polymerase chain reaction assay, the intracellular production of IL-10 by monocytes by means of flow cytofluorometry, and IL-10 levels in the 24-hour monocyte culture supernatants by enzyme immunoassay. Results. The IL-10-1082AA genotype was more common in women with FGR. Changes were found in the synthesis and production of IL-10 by monocytes in relation to the allelic variant of the IL-10 A-1082G polymorphism. Conclusion. The most significant risk factors for FGD are tobacco smoking, extragenital pathology, and a compromised obstetric and gynecological history. The results of the study may suggest that the L-10 A-1082G polymorphism is an additional factor regulating the immune balance during pregnancy when FGR develops.

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About the authors

Anna Ivanovna Malyshkina

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of the Russian Federation; Ivanovo State Medical Academy, Ministry of Health of the Russian Federation

Email: ivniimid@inbox.ru
doctor of medical sciences, professor, director

Yelena L’vovna Boiko

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of the Russian Federation

Email: Dr-Boyko@mail.ru
doctor of medical sciences, senior researcher, Department of Obstetrics and Gynecology

Natal’ya Yur’yevna Sotnikova

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of the Russian Federation; Ivanovo State Medical Academy, Ministry of Health of the Russian Federation

Email: niimid.immune@mail.ru
doctor of medical sciences, Professor, head. laboratory of clinical immunology

Irina Aleksandrovna Panova

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of the Russian Federation

Email: ia_panova@mail.ru
doctor of medical sciences, assistant professor, head of Department of obstetrics and gynecology

Irina Nikolayevna Fetisova

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of the Russian Federation; Ivanovo State Medical Academy, Ministry of Health of the Russian Federation

Email: ivgenlab@gmail.com
doctor of medical sciences, Professor of the Department of Obstetrics and Gynecology, Medical Genetics

Dmitriy Nikolayevich Voronin

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of the Russian Federation

Email: niimid.immune@mail.ru
candidate of biological sciences, researcher of the clinical immunology laboratory

Polina Leonidovna Mileeva

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of the Russian Federation

Email: pvasilevskai@gmail.com
obstetrician-gynecologist obstetric physiological department of the inpatient department of the clinic

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