Complete zona pellucida removal from blastocysts prior to transfer in a cryo-cycle does not affect the efficiency of in vitro fertilization programs
- Authors: Kirienko K.V.1, Apryshko V.P.1,2, Mironova A.G.1,3, Kharitonova M.A.1, Ermilova I.Y.1, Naumova A.A.1, Klepukov A.A.1, Bolt A.I.1, Bozina I.V.1, Lebedeva E.B.1, Simonenko E.Y.2, Yakovenko S.A.1,2
-
Affiliations:
- AltraVita Clinic of Human Reproduction, OOO "ECO CENTER"
- M.V. Lomonosov Moscow State University
- N.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- Issue: No 6 (2019)
- Pages: 88-93
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/248553
- DOI: https://doi.org/10.18565/aig.2019.6.88-93
- ID: 248553
Cite item
Abstract
Keywords
Full Text
![Restricted Access](https://journals.eco-vector.com/lib/pkp/templates/images/icons/text_lock.png)
About the authors
Konstantin Vladimirovich Kirienko
AltraVita Clinic of Human Reproduction, OOO "ECO CENTER"
Email: kkiriyenko@rambler.ru
Valentina Petrovna Apryshko
AltraVita Clinic of Human Reproduction, OOO "ECO CENTER"; M.V. Lomonosov Moscow State University
Email: supermycolog@mail.ru
Anna Gennadievna Mironova
AltraVita Clinic of Human Reproduction, OOO "ECO CENTER"; N.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Margarita Aleksandrovna Kharitonova
AltraVita Clinic of Human Reproduction, OOO "ECO CENTER"
Email: ritasarc@mail.ru
Irina Yurievna Ermilova
AltraVita Clinic of Human Reproduction, OOO "ECO CENTER"
Email: i_ermilova@altravita.ru
Anna Aleksandrovna Naumova
AltraVita Clinic of Human Reproduction, OOO "ECO CENTER"
Email: naumo.ann@yandex.ru
Alexey Aleksandrovich Klepukov
AltraVita Clinic of Human Reproduction, OOO "ECO CENTER"
Email: klepukov@altravita.ru
Anton Igorevich Bolt
AltraVita Clinic of Human Reproduction, OOO "ECO CENTER"
Email: a_bolt@altravita.ru
Iana Vadimovna Bozina
AltraVita Clinic of Human Reproduction, OOO "ECO CENTER"
Email: yana.bozina@gmail.com
Elena Borisovna Lebedeva
AltraVita Clinic of Human Reproduction, OOO "ECO CENTER"
Email: lebedester@gmail.com
Ekaterina Yurevna Simonenko
M.V. Lomonosov Moscow State University
Email: ksimonenko@inbox.ru
Sergey Aleksandrovich Yakovenko
AltraVita Clinic of Human Reproduction, OOO "ECO CENTER"; M.V. Lomonosov Moscow State University
Email: altravita@mail.ru
References
- Fujiwara K., Sano D., Seita Y., Inomata T., Ito J., Kashiwazaki N. Ethylene glycol-supplemented calcium-free media improve zona penetration of vitrified rat oocytes by sperm cells. J. Reprod. Dev. 2010; 56(1): 169-75. https://doi. org/10.1262/jrd.09-107H.
- Hiraoka K., Fuchiwaki M., Hiraoka K., Horiuchi T., Murakami T., Kinutani M. et al. Re-cryopreservation by vitrification of human blastocysts developed from frozencleaved embryos: a report of 15 cycles. J. Mammalian Ova Res. 2007; 24(1): 23-8. https://doi.org/10.1274/jmor.24.23.
- Martins W.P., Rocha I.A., Ferriani R.A., Nastri C.O. Assisted hatching of human embryos: a systematic review and meta-analysis of randomized controlled trials. Hum. Reprod. Update. 2011; 17(4): 438-53. https://doi.org/10.1093/ humupd/dmr012.
- Vajta G., Rienzi L., Bavister B.D. Zona-free embryo culture: is it a viable option to improve pregnancy rates? Reprod. Biomed. Online. 2010; 21: 17-25. https:// doi.org/10.1016/j.rbmo.2010.03.014.
- Hiraoka K., Fuchiwaki M., Horiuchi T., Murakami T., Kinutani M., Kinutani K. Zona pellucida removal and vitrified blastocyst transfer outcome: a preliminary study. Reprod. Biomed. Online. 2007; 15(1): 68-75. https://doi.org/10.1016/ S1472-6483(10)60694-3.
- Yakovenko S., Apryshko V., Yutkin E., Troshina M., Simonenko E. Technique and effectiveness of intracytoplasmic morphologically selected sperm injection (IMSI) based on HMC (Hoffman modulation contrast). Fertil. Steril. 2009; 92( 3, Suppl.): S162. (Scientific Abstracts from the 2009 Annual Meeting of the American Society for Reproductive Medicine.)
- Yakovenko S. IMSI Hoffman modulation. In: International Workshop on Male Infertility - IMSI: new advances. June 24-27, 2010 Rome, Italy.
- Jelinkova L., Pavelkova J., Strehler E., Paulus W, Zivny J., Sterzik K. Improved implantation rate after chemical removal of the zona pellucida. Fertil. Steril. 2003; 79(6): 1299-303. https://doi.org/10.1016/S0015-0282(03)00260-7.
- Kinget K., Nijs M., Cox A.M., Janssen M., Jacobs P., Bosmans E. et al. A novel approach for patients at risk for ovarian hyperstimulation syndrome, elective transfer of a single zona-free blastocyst on day 5. Reprod. Biomed. Online. 2002; 4: 51-5. https://doi.org/10.1016/S1472-6483(10)61915-3.
- Isik A.Z, Vicdan K., Kaba A., Dagli G. Comparison of zona manipulated and zona intact blastocyst transfers, a prospective randomized trial. J. Assist. Reprod. Genet. 2000; 17(3): 135-9. https://doi.org/10.1023/A:1009410020580.
- Urman B., Balaban B., Alatas C., Aksoy S., Mumcu A., Isiklar A. Zona-intact versus zona-free blastocyst transfer, a prospective, randomized study. Fertil. Steril. 2002; 78(2): 392-6. https://doi.org/10.1016/S0015-0282(02)03238-7.
- Mansour R.T., Rhodes C.A., Aboulghar M.A., Serour G.I., Kamal A. Transfer of zona-free embryos improves outcome in poor prognosis patients, a prospective randomized controlled study. Hum. Reprod. 2000; 15(5): 1061-4. https://doi. org/10.1093/humrep/15.5.1061.
- Lan K.C., Huang F.J., Lin Y.C., Kung F.T., Chang S.Y. Zona-free versus laser zona-assisted hatching blastocyst transfer, a comparison of outcomes. Fertil. Steril. 2009; 91(5): 1959-62. https://doi.org/10.1016/j.fertnstert.2008.01.068.
- Hiraoka K., Fuchiwaki M., Hiraoka K., Horiuchi T., Murakami T., Kinutani M. et al. Zona pellucida removal and vitrified blastocyst transfer outcome, a preliminary study. Reprod. Biomed. Online. 2007; 15(1): 68-75.
- Carney S.K., Das S., Blake D., Farquhar C., Seif M.M., Nelson L. Assisted hatching on assisted conception in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Cochrane Database Syst. Rev. 2012; (12): CD001894. https://doi.org/10.1002/14651858.CD001894.pub5.
- Li D., Yang D.L., An J., Jiao J., Zhou Y.M., Wu Q.J. et al. Effect of assisted hatching on pregnancy outcomes, a systematic review and meta-analysis of randomized controlled trials. Sci. Rep. 2016; 6: 31228. https://doi.org/10.1038/ srep31228.
- Ueno S., Ezoe K., Yabuuchi A., Uchiyama K., Okimura T., Okuno T. et al. Complete zona pellucida removal from vitrified-warmed human blastocysts facilitates earlier in-vitro attachment and outgrowth. Reprod. Biomed. Online. 2016; 33(2): 140-8. https://doi.org/10.1016/j.rbmo.2016.05.007.
Supplementary files
![](/img/style/loading.gif)