Premature births: how to manage tocolysis


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Abstract

Objective. To elaborate a pathogenetic approach to tocolytic therapy. Subjects and methods. A total of 146 patients with clinical presentations of preterm labor at 24 to 34 weeks’ gestation were examined. Results. In 71.9% of pregnant women, tocolysis with atosiban could prolong pregnancy for 48 hours or more. Pregnancy could be prolonged for an average of 13.1±3.5 days. Further examination revealed cervical canal infection in 71.2% of women. In addition, the study showed that the expression of toll-like receptor (TLR) in the cervical canal epithelium was enhanced in women without cervical infection. Conclusion. Our investigations have demonstrated that cyclooxygenase inhibitors should be the leading tocolytic agents and it is necessary to use antibacterial therapy to enhance the efficiency of tocolysis.

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About the authors

Vera S. Belousova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: desdemosha@mal.ru
corresponding author-Candidate of Medical Sciences, Associate Professor of the Department of Obstetrics, Gynecology and Perinatology at the Medical Faculty

Alexander N. Strizhakov

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: kafedra-agp@mail.ru
Academician of the Russian Academy of Sciences, Doctor of Medical Sciences, Professor, Head of the Department of Obstetrics, Gynecology and Perinatology at the Medical Faculty

Elena Vladimirovna Timokhina

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: elena.timokhina@mail.ru
Doctor of Medical Sciences, Professor of the Department of Obstetrics, Gynecology and Perinatology at the Medical Faculty

Irina Mikhailovna Bogomazova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: irinka.bogomazova@mail.ru
Candidate of Medical Sciences, Associate Professor of the Department of Obstetrics, Gynecology and Perinatology at the Medical Faculty

Elena Germanovna Pirskhelauri

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: elena-doc@rambler.ru
Candidate of Medical Sciences, Associate Professor of the Department of Obstetrics, Gynecology and Perinatology at the Medical Faculty

Elena Sergeevna Emelyanova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: kafedra-agp@mail.ru
a student of the medical faculty

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